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research A Novel Epithelial Keratin, hK6irs1, is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells (Flügelzellen) of the Human Hair Follicle

86 citations , May 2002 in “Journal of Investigative Dermatology”

A new keratin, hK6irs1, is found in all layers of the hair follicle's inner root sheath.

research Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

265 citations , March 1993 in “The EMBO Journal”

Keratinocyte growth factor significantly alters skin and tissue development.

research Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium

56 citations , July 2004 in “Mechanisms of Development”

Pax9 is crucial for proper tongue surface development and preventing skin-like changes.

research A group of type I keratin genes on human chromosome 17: characterization and expression.

141 citations , February 1988 in “Molecular and Cellular Biology”

Only one K16 gene on chromosome 17 makes a functional keratin protein.

The Relationship Between Keratin 18 and Epithelial-Derived Tumors: As a Diagnostic Marker, Prognostic Marker, and Its Role in Tumorigenesis

research The relationship between keratin 18 and epithelial-derived tumors: as a diagnostic marker, prognostic marker, and its role in tumorigenesis

October 2024 in “Frontiers in Oncology”

Keratin 18 helps diagnose and predict cancer progression and affects cancer growth and spread.

research Significance of stress keratin expression in normal and diseased epithelia

47 citations , January 2024 in “iScience”

Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.

Autosomal Recessive Transmission of a Rare KRT74 Variant Causes Hair and Nail Ectodermal Dysplasia: Allelism with Dominant Woolly Hair/Hypotrichosis

research Autosomal Recessive Transmission of a Rare KRT74 Variant Causes Hair and Nail Ectodermal Dysplasia: Allelism with Dominant Woolly Hair/Hypotrichosis

21 citations , April 2014 in “PLoS ONE”

A rare gene variant causes hair and nail issues in a family.

research Cytokeratins as Markers of Follicular Differentiation

121 citations , December 2001 in “American Journal of Dermatopathology”

TB and BCC tumors show similar follicular differentiation patterns.

research Keratin Expression Provides Novel Insight into the Morphogenesis and Function of the Companion Layer in Hair Follicles

38 citations , December 2006 in “Journal of Investigative Dermatology”

Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.

research The FRZB gene regulates hair follicle development in rabbits via the Wnt/β-catenin signaling pathway

September 2023 in “World Rabbit Science”

The FRZB gene slows hair growth in rabbits.

research Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice

49 citations , August 2004 in “The FASEB Journal”

Mice with human skin protein K8 had more skin problems and cancer.

research 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles

April 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

CTCF protein is essential for skin and hair follicle development in mice.

research 0749 Serine and arginine-rich splicing factor 3 regulates epidermal differentiation in cutaneous squamous cell carcinoma

July 2025 in “Journal of Investigative Dermatology”

research Reply to: The ends of a conundrum?

March 2007 in “Journal of Cell Science”

K10 may not prevent tumors as previously thought and might increase benign tumor risk.

research ROLE OF THE TRANSCRIPTION FACTOR SOX9 IN THE TUMORIGENESIS OF SOME DOMESTIC ANIMALS NEOPLASMS

April 2016 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

Sox9 is important in the development of tumors in domestic animals.

research Keratin 79 identifies a novel population of migratory epithelial cells that initiates hair canal morphogenesis and regeneration

3 citations , December 2013 in “Journal of Cell Science”

Keratin 79 cells help form and regenerate hair canals.

research Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

24 citations , July 1994 in “Molecular Endocrinology”

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

research Variation in the Exon 3–4 Region of Ovine KRT85 and Its Effect on Wool Traits

1 citations , August 2024 in “Animals”

KRT85 gene variations can help improve wool traits in sheep through selective breeding.

research Trichorhinophalangeal syndrome with low expression of TRPS1 on epidermal and hair follicle epithelial cells

16 citations , March 2013 in “The Journal of Dermatology”

Low TRPS1 expression in skin and hair cells is linked to hair problems in Trichorhinophalangeal syndrome.

research Immunohistochemical Demonstration of Keratin 19 Expression in Isolated Human Hair Follicles

43 citations , August 1994 in “Journal of Investigative Dermatology”

research Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma

87 citations , January 1999 in “British Journal of Dermatology”

Trichoblastic fibroma and basal cell carcinoma are similar but different from trichoepithelioma.

research Identification of Somatic KRAS Mutation in a Korean Baby with Nevus Sebaceus Syndrome

3 citations , December 2014 in “Annals of Laboratory Medicine”

A Korean baby with nevus sebaceus syndrome was found to have a KRAS gene mutation.

research Expression of the Intermediate Filament Keratin Gene,K15,in the Basal Cell Layers of Epithelia and the Hair Follicle

46 citations , November 1998 in “Experimental Cell Research”

K15 gene is mainly active in the basal layers of hair follicles and epithelia, aiding early skin cell development.

research Transgenic mouse models support HCR as an effector gene in the PSORS1 locus

37 citations , June 2004 in “Human molecular genetics online/Human molecular genetics”

The HCR gene contributes to psoriasis risk.

research Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

119 citations , August 2008 in “BMC Evolutionary Biology”

KRTAP genes evolved early in mammals, leading to diverse hair traits.

research A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin.

156 citations , January 1989 in “Genes & Development”

Keratin expression reflects cell organization and differentiation, not causes it.

Differential Expression of Keratin and Keratin-Associated Proteins Linked with Hair Loss in Spontaneously Mutated Inbred Mice

research Differential expression of keratin and keratin associated proteins are linked with hair loss condition in spontaneously mutated inbred mice

July 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in certain mice is linked to changes in keratin-related genes.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research Signaling from keratins

May 2006 in “The Journal of Cell Biology”

Keratin 17 is crucial for cell growth in wound healing by aiding protein synthesis.

research Ornithine decarboxylase expression in cutaneous papillomas in SENCAR mice is associated with altered expression of keratins 1 and 10.

33 citations , March 1994 in “PubMed”

High ODC and low K1 and K10 may indicate early skin tumors in mice.

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