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research Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene

January 2022 in “Mammalian Genome”

The wavy coat in NCT mice is caused by multiple genes, including a mutation in the Prss53 gene.

research The Type I Keratin 19 Possesses Distinct and Context-dependent Assembly Properties

46 citations , December 1998 in “Journal of Biological Chemistry”

Keratin 19 forms less stable and shorter filaments than keratin 14, giving unique traits to certain skin cells.

research The association between rs2476601 polymorphism in PTPN22 gene and risk of alopecia areata

9 citations , May 2019 in “Medicine”

The C-allele and CC-genotype in the PTPN22 gene lower the risk of alopecia areata.

research Molecular studies of transient receptor potential Vanilloid 3 (TRPV3)

January 2024 in “OPAL (Open@LaTrobe) (La Trobe University)”

TRPV3 channels are involved in skin processes and are affected by shear stress, influencing itch and mechanotransduction.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research TON1 recruiting motif 21 positively regulates the flavonoid metabolic pathway at the translational level in Arabidopsis thaliana

February 2024 in “Planta”

TRM21 helps control flavonoid production and root hair growth in Arabidopsis thaliana.

research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

137 citations , October 2009 in “The American journal of pathology”

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

research Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome

2 citations , February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Impaired LEF1 activation speeds up skin cell development in Hutchinson-Gilford Progeria Syndrome.

research Epidermal expression of receptor for advanced glycation end products (RAGE) is related to inflammation and apoptosis in human skin

10 citations , November 2015 in “Experimental Dermatology”

Skin RAGE levels are linked to inflammation and cell death.

research STUB1 mutations in autosomal recessive ataxias – evidence for mutation-specific clinical heterogeneity

65 citations , September 2014 in “Orphanet Journal of Rare Diseases”

Different STUB1 gene mutations cause varied symptoms in autosomal recessive ataxias.

Immunohistochemical, Pharmacovigilance, and Omics Analyses Reveal the Involvement of ATP-Sensitive K+ Channel Subunits in Cancers: Role in Drug-Disease Interactions

research Immunohistochemical, pharmacovigilance, and omics analyses reveal the involvement of ATP-sensitive K+ channel subunits in cancers: role in drug–disease interactions

3 citations , April 2023 in “Frontiers in Pharmacology”

ATP-sensitive K+ channel subunits, particularly Sur2A, play a significant role in various cancers.

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

87 citations , November 2002 in “Journal of Investigative Dermatology”

research K6irs1, K6irs2, K6irs3, and K6irs4 Represent the Inner-Root-Sheath-Specific Type II Epithelial Keratins of the Human Hair Follicle1

130 citations , April 2003 in “Journal of Investigative Dermatology”

Four specific keratins in hair follicles help understand hair structure and function.

research The Transcriptional Regulator Prdm1 Is Essential for the Early Development of the Sensory Whisker Follicle and Is Linked to the Beta-Catenin First Dermal Signal

1 citations , October 2022 in “Biomedicines”

Prdm1 is necessary for early whisker development in mice but not for other hair, and its absence changes nerve and brain patterns related to whiskers.

research Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

10 citations , November 2018 in “Genetics in medicine”

Lack of cystatin M/E causes thin hair and dry skin.

research Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals

11 citations , November 2015 in “Carcinogenesis”

Deleting TNFα gene reduces skin cancer risk in certain mice.

research A Receptor-Like Kinase Mediates Ammonium Homeostasis and Is Important for the Polar Growth of Root Hairs inArabidopsis

107 citations , April 2014 in “The Plant cell”

The CAP1 gene helps control ammonium levels and is necessary for the proper growth of root hairs in Arabidopsis.

research The metabolic syndrome- associated small G protein ARL15 plays a role in adipocyte differentiation and adiponectin secretion

23 citations , December 2017 in “Scientific Reports”

ARL15 is important for fat cell development and the release of the hormone adiponectin.

A New Mutation Resulting in the Truncation of the TRAF6-Interacting Domain of XEDAR: A Possible Novel Cause of Hypohidrotic Ectodermal Dysplasia

research A new mutation resulting in the truncation of the TRAF6-interacting domain of XEDAR: a possible novel cause of hypohidrotic ectodermal dysplasia: Figure 1

17 citations , August 2012 in “Journal of Medical Genetics”

A new mutation in the XEDAR gene might cause a rare skin condition called hypohidrotic ectodermal dysplasia.

research Differential expression of type I IRS keratin genes in three breeds of sheep

January 2012 in “Zhongguo shouyi xuebao”

Sheep breeds show different keratin gene expression in the groin, linked to hair follicle density.

research Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle

9 citations , July 2011 in “Scientific Reports”

Changes in the HR gene have influenced hair growth and may lead to hair loss conditions in humans.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

Genetic Alteration of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase Subunit Expression Affects Calcium Currents and Beta-Endorphin Release in AtT-20 Clonal Pituitary Cells

research Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells.

August 1994 in “Molecular Endocrinology”

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

Identification and Characterization of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2

research Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2

8 citations , January 2012 in “JIMD reports”

A new mutation in the AGPAT2 gene causes severe fat tissue loss and related health issues by reducing the protein's levels.

research Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

76 citations , May 2011 in “Cell death and differentiation”

A20 protein is crucial for normal skin and hair development.

Molecular Cloning and Expression Analysis of Prostaglandin E Receptor 2 Gene in Cashmere Goat (Capra hircus) Skin During Hair Follicle Development

research Molecular Cloning and Expression Analysis of Prostaglandin E Receptor 2 Gene in Cashmere Goat (Capra hircus) Skin during Hair Follicle Development

2 citations , February 2014 in “Animal Biotechnology”

The PTGER2 gene is highly active in Cashmere goat skin and its activity changes with the hair growth cycle.

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