788 citations
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February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
773 citations
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August 2017 in “International Journal of Molecular Sciences” The secretions of mesenchymal stem cells could be used for healing without using the cells themselves.
759 citations
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February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
688 citations
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June 2007 in “Cell Stem Cell” Removing the ATR gene in adult mice causes rapid aging and stem cell loss.
667 citations
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May 2008 in “Genes & Development” Histone demethylases can change gene expression and may be linked to diseases like cancer.
658 citations
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June 2003 in “Endocrine reviews” Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.
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September 1998 in “The Journal of Clinical Endocrinology and Metabolism” PCOS affects a similar percentage of Black and White women in the Southeastern United States.
610 citations
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April 2014 in “Nature Reviews Immunology” The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.
522 citations
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January 2001 in “Cancer investigation” Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
506 citations
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January 2012 in “Molecular and Cellular Endocrinology” Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
499 citations
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September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
480 citations
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August 2014 in “Nature Biotechnology” Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.
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January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
474 citations
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January 2012 in “Chemistry & biology” Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.
471 citations
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October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
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May 2008 in “British Journal of Pharmacology” Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.
438 citations
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October 2010 in “Oncogene” Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.
437 citations
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August 2014 in “Cell metabolism” Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.
431 citations
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October 2008 in “Current Medicinal Chemistry” Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.
421 citations
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April 2012 in “The New England Journal of Medicine” Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.
411 citations
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April 2010 in “Gastroenterology” Targeting colon cancer stem cells might lead to better treatment results.
408 citations
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January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
405 citations
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May 2007 in “Journal of The American Academy of Dermatology” Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.
401 citations
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January 2013 in “Postepy Dermatologii I Alergologii” The paper concludes that understanding melanocyte development can help in insights into skin diseases and melanoma diversity.
396 citations
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May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
378 citations
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September 1998 in “The Journal of Clinical Endocrinology and Metabolism” PCOS affects about 4% of women in the southeastern U.S. equally across Black and White populations.
375 citations
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July 2006 in “Journal of Investigative Dermatology” Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.
374 citations
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May 2016 in “The Lancet. Diabetes & endocrinology” Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.
363 citations
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March 2017 in “Nature Communications” Stem cells help heal wounds by rapidly dividing and migrating to the wound edge.