44 citations
,
May 2012 in “Endocrinology” High levels of androgens during early development may cause PCOS-like symptoms.
34 citations
,
February 2016 in “Fertility and Sterility” More PDCD4 is linked to obesity, insulin problems, and cell death in ovaries for those with polycystic ovary syndrome.
The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.
PCOS is a complex condition that can lead to serious health issues, but early diagnosis and treatment can reduce these risks.
February 2020 in “Acta Scientific Women's Health” PCOS is a common condition in women that can lead to infertility and other health issues, and it's diagnosed by specific criteria with various treatment options available.
January 2001 in “Cambridge University Press eBooks” Early signs of PCOS in girls, like irregular periods and polycystic ovaries, suggest a need for early diagnosis and intervention to prevent further health issues.
991 citations
,
January 2011 in “Nature Reviews Endocrinology” The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
408 citations
,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
369 citations
,
June 2013 in “Biochimie” Myo-inositol supplements may improve insulin sensitivity and help with conditions like PCOS and gestational diabetes, but more research is needed.
343 citations
,
December 2008 in “Endocrine Reviews” Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.
299 citations
,
January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
286 citations
,
January 2009 in “Human Reproduction Update” Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.
271 citations
,
June 2013 in “Human Reproduction” PCOS is common among Chinese women of reproductive age and linked to serious metabolic and reproductive issues, especially in obese women.
270 citations
,
April 2007 in “The Journal of Clinical Endocrinology and Metabolism” Women with PCOS often have more belly fat and higher insulin levels, but belly fat isn't the only cause of their insulin resistance.
258 citations
,
July 2016 in “Reproductive Biology and Endocrinology” The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
195 citations
,
November 2019 in “Clinica Chimica Acta” High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.
166 citations
,
October 2018 in “Endocrine Reviews” Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.
162 citations
,
April 2016 in “The Lancet Diabetes & Endocrinology” Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.
132 citations
,
January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
128 citations
,
September 2011 in “British Journal of Dermatology” Obesity is linked to various skin problems and may increase the risk of skin cancer.
124 citations
,
June 2020 in “Cell Stem Cell” Fat cells in the skin help start healing and form important repair cells after injury.
115 citations
,
October 2009 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” The research found that Atypical Progeroid Syndrome has unique symptoms and is not caused by the buildup of a certain mutant protein.
114 citations
,
January 2014 in “World Journal of Gastroenterology” People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.
106 citations
,
October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
103 citations
,
June 2018 in “International Journal of Molecular Sciences” FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.
98 citations
,
December 2008 in “Journal of Investigative Dermatology” Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.
97 citations
,
September 2016 in “Reviews in Endocrine and Metabolic Disorders” The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.
92 citations
,
September 2015 in “Journal of Lipid Research” Skin fat helps with body temperature control and has other active roles in health.
91 citations
,
December 2017 in “Systems Biology in Reproductive Medicine” Lower SHBG levels may increase the risk of PCOS.
81 citations
,
February 2019 in “Experimental & Molecular Medicine” PAK4 is crucial in cancer progression, brain development, and could be a therapeutic target, especially through the PAK4-CREB axis.