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Did you mean Lysyl Hydroxylase?

GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations , December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations , January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note

2 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , October 2009 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations , January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

research Inflammatory perifollicular fibrosis and alopecia

10 citations , June 1998 in “International Journal of Dermatology”

Inflammation around hair follicles leads to hair loss, and treatments should focus on reducing this inflammation and other factors for effectiveness.

research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

6 citations , August 2024 in “Biomacromolecules”

The model helps test drugs for clubfoot fibrosis by mimicking cell environments and shows minoxidil reduces harmful collagen links.

research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp

5 citations , October 1988 in “Clinics in Dermatology”

Minoxidil promotes hair growth but exact mechanism is unknown.

research The Effect of the Drug Minoxidil on Hair Growth

3 citations , January 1988

Minoxidil helps hair grow, especially in people with mild hair loss.

research Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment.

March 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Minoxidil treatment improves heart defects in a DiGeorge syndrome model.

research Chelators Depigment and Inorease Elasticity of Mink Skin

2 citations , January 1987 in “Acta Agriculturae Scandinavica”

Certain chelators lighten mink skin and hair, increase skin elasticity, and disrupt hair growth without affecting fur quality.

research Central chorioretinopathy associated with topical use of minoxidil 2% for treatment of baldness

9 citations , September 2011 in “Cutaneous and Ocular Toxicology”

Using 2% minoxidil for baldness treatment might cause vision distortion due to fluid build-up under the retina.

research Chapter 20. Pathogenesis and Treatment of Alopecias

8 citations , January 1989 in “Annual Reports in Medicinal Chemistry”

Hair loss from alopecia areata and androgenetic alopecia can be treated, but more effective and safer treatments are needed.

Low-Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% for Sustainable Hair Regrowth

research Low‐Level Light Therapy Downregulates Scalp Inflammatory Biomarkers in Men With Androgenetic Alopecia and Boosts Minoxidil 2% to Bring a Sustainable Hair Regrowth Activity

4 citations , May 2021 in “Lasers in Surgery and Medicine”

Light therapy reduces scalp inflammation, boosts hair regrowth with Minoxidil 2%.

Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-Month Randomized Trial

research Comparative Study Between 2% Minoxidil Topical Spray vs. Intradermal Injection (Mesotherapy) for Treatment of Androgenetic Alopecia in Female Patients: A Controlled, 4-month Randomized Trial

1 citations , January 2010

Mesotherapy is more effective than topical spray for female hair loss treatment.

research Solubility of Minoxidil in Methanol, Ethanol, 1-Propanol, 2-Propanol, 1-Butanol, and Water from (278.15 to 333.15) K

24 citations , April 2011 in “Journal of Chemical & Engineering Data”

Minoxidil dissolves best in methanol and least in water.

research Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model

9 citations , August 2024 in “Tissue Engineering and Regenerative Medicine”

Collagen-heparin-FGF2-VEGF scaffolds can improve skin healing.

research Minoxidil restores thymic growth in 22q11.2 deletion syndrome by limiting Sox9+ chondrocyte expansion

1 citations , August 2025 in “Journal of Human Immunity”

Minoxidil helps restore thymus size in 22q11.2 deletion syndrome.

research Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome

9 citations , September 2022 in “Journal of Clinical Investigation”

Replacing defective mesenchymal cells with normal ones fixes thymic growth issues in 22q11.2DS mouse models.

research Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts

9 citations , March 2019 in “Molecular & cellular proteomics”

Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.

research The genetics of hair shaft disorders

59 citations , June 2008 in “Journal of The American Academy of Dermatology”

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

research A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration

16 citations , January 2011 in “Archives of Dermatological Research”

The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.

research The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches

42 citations , May 2016 in “Annual Review of Cell and Developmental Biology”

Fat cells are important for tissue repair and stem cell support in various body parts.

ADM Scaffolds Generate a Pro-Regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

research ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

17 citations , June 2018 in “Frontiers in Physiology”

ADM scaffolds help skin heal by promoting a healing-type immune response.

research HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

6 citations , January 2020 in “Skin Pharmacology and Physiology”

HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

Skin Aging and Menopause: Implications for Treatment

research Skin Aging and Menopause

180 citations , January 2003 in “American Journal of Clinical Dermatology”

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.