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Did you mean Lysyl Hydroxylase?

GlossaryLysyl Hydroxylase

enzyme modifying lysine in collagen for tissue strength

Lysyl Hydroxylase is an enzyme that plays a crucial role in the formation of collagen, a protein that provides structure and strength to connective tissues like skin, hair, and bones. It specifically modifies lysine residues in collagen, enabling the collagen fibers to form stable cross-links, which are essential for the tissue's mechanical properties. Deficiencies or mutations in this enzyme can lead to connective tissue disorders.

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Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine

46 citations , December 1992 in “Journal of Investigative Dermatology”

Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

research Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note

2 citations , October 2020 in “Journal of Pharmacology and Experimental Therapeutics”

Minoxidil does not work to inhibit lysyl hydroxylases in newborn mouse lungs.

research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.

63 citations , September 1987 in “Journal of Biological Chemistry”

Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.

research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts

20 citations , January 1994 in “Archives of Biochemistry and Biophysics”

Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.

research Structural Requirements of Minoxidil Analogs for Enhancing Lysyl Hydroxylase Inhibitory Activity

April 2012 in “KSBB Journal”

Minoxidil analogs can be improved for hair growth inhibition by modifying specific parts of their structure.

research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis

6 citations , August 2024 in “Biomacromolecules”

The model helps test drugs for clubfoot fibrosis by mimicking cell environments and shows minoxidil reduces harmful collagen links.

research Effects of Minoxidil on Cultured Human Skin Fibroblasts

19 citations , January 1987 in “Dermatology”

Minoxidil slows down skin cell growth and may help treat scars and skin conditions.

research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action

37 citations , January 1987 in “Dermatology”

Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.

research Inflammatory perifollicular fibrosis and alopecia

10 citations , June 1998 in “International Journal of Dermatology”

Inflammation around hair follicles leads to hair loss, and treatments should focus on reducing this inflammation and other factors for effectiveness.

research Androgenetic alopecia, trichotrophic substances, and histologic studies of the human scalp

5 citations , October 1988 in “Clinics in Dermatology”

Minoxidil promotes hair growth but exact mechanism is unknown.

research The Effect of the Drug Minoxidil on Hair Growth

3 citations , January 1988

Minoxidil helps hair grow, especially in people with mild hair loss.

research Cardiac Outflow tract septation defects in a DiGeorge syndrome model respond to Minoxidil treatment.

March 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Minoxidil treatment improves heart defects in a DiGeorge syndrome model.

Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

research Abstracts from the Symposium on the Pathophysiology of Hair Growth Organized by the Institute of Dermatology at the Royal Society of Medicine, 29 October 1987

January 1989 in “Clinical and Experimental Dermatology”

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

research Chelators Depigment and Inorease Elasticity of Mink Skin

2 citations , January 1987 in “Acta Agriculturae Scandinavica”

Certain chelators lighten mink skin and hair, increase skin elasticity, and disrupt hair growth without affecting fur quality.

research Effect of minoxidil on rabbit lens epithelial cell behavior in vitro and in situ

21 citations , September 2001 in “Graefes Archive for Clinical and Experimental Ophthalmology”

Minoxidil may help prevent capsular opacification after cataract surgery.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations , February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

research Minoxidil Stimulates Elastin Expression in Aortic Smooth Muscle Cells

33 citations , November 1994 in “Archives of Biochemistry and Biophysics”

research Stimulation of elastin expression by minoxidil in chick skin fibroblasts

15 citations , January 1995 in “Archives of Dermatological Research”

Minoxidil boosts elastin production, potentially helping skin diseases.

research Minoxidil Use in Dermatology, Side Effects and Recent Patents

152 citations , April 2012 in “Recent Patents on Inflammation & Allergy Drug Discovery”

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

research Cosmeceuticals in Dermatology

1 citations , January 2013 in “Springer eBooks”

Cosmeceuticals may benefit skin health but need more research for efficacy and safety confirmation.

research Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases

47 citations , September 2023 in “Pharmacological Reports”

Vitamins A, B3, C, D, and E can improve skin health and immunity.

research Minoxidil: mechanisms of action on hair growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Medical treatments for male and female pattern hair loss

212 citations , September 2008 in “Journal of The American Academy of Dermatology”

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Skin Aging and Menopause: Implications for Treatment

research Skin Aging and Menopause

180 citations , January 2003 in “American Journal of Clinical Dermatology”

Menopause can lead to skin and hair problems due to hormonal changes, but hormone replacement therapy might help slow these effects.

research Hormone replacement therapy and the skin

138 citations , May 2000 in “Maturitas”

Estrogen replacement can improve skin health in menopausal women but doesn't reverse sun damage or prevent hair loss.

research Estrogens and the skin

137 citations , June 2005 in “Climacteric”

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

research Skin connective tissue and ageing

77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

research Multi-therapies in androgenetic alopecia: review and clinical experiences

55 citations , July 2016 in “Dermatologic Therapy”

Multiple treatments work best for hair loss.

research Oral Manifestations of Hematologic and Nutritional Diseases

50 citations , November 2010 in “Otolaryngologic Clinics of North America”

Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.