2 citations
,
November 1978 in “JAMA” Valproic acid is an effective seizure medication with some temporary side effects.
Sodium valproate improved epilepsy control in most children but often caused weight gain and other mild side effects.
44 citations
,
December 1975 in “Developmental Medicine & Child Neurology” Sodium valproate effectively controls petit mal seizures in children but is less effective for other types, with minimal side effects.
January 2011 in “Arqueología, historia y viajes sobre el mundo medieval/Arqueología, historia y viajes sobre el mundo medieval” Sodium valproate can cause severe liver disease and side effects, sometimes leading to death.
August 2018 in “Online journal of neurology and brain disorders” Sodium valproate is effective in treating epilepsy, especially in patients who don't respond to other medications.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
13 citations
,
October 2010 in “Seizure” Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.
73 citations
,
January 1980 in “Annals of Neurology” Valproic acid can cause serious side effects, including pancreatitis and even death.
7 citations
,
September 2007 Valproate sustained-release is effective and generally safe for short-term treatment of new partial epilepsy.
September 2018 in “Practical diabetes” Sodium valproate is not recommended as a first-line treatment for neuropathy but may be used in resistant cases.
21 citations
,
April 2011 in “Epilepsia” The drug combination significantly reduced epileptic drop attacks in patients.
4 citations
,
January 2019 in “PubMed” Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
January 2004 in “Headache” Divalproex sodium significantly improved headaches in two-thirds of patients.
16 citations
,
October 1994 in “PubMed” Sodium valproate is a safe and effective epilepsy drug with manageable side effects.
July 2020 in “Scholars journal of applied medical sciences” Sodium valproate caused vomiting, hair loss, loss of appetite, abdominal pain, weight gain, and anemia in young children with epilepsy.
2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
Levetiracetam and valproate sodium both reduce seizures when added to lamotrigine, but levetiracetam has fewer side effects.
June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science” New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.
May 2021 in “American journal of medical sciences and medicine” Sodium valproate caused vomiting in 20% of children under 2 years old, with other side effects like hair loss and loss of appetite also noted.
169 citations
,
August 1981 in “BMJ” Sodium valproate improved epilepsy control but often caused weight gain in children.
18 citations
,
January 2009 in “Acta neurologica Scandinavica” Long-term sodium valproate treatment for epilepsy generally caused mild and temporary side effects.
4 citations
,
October 1993 in “PubMed” Valproic acid can cause mild side effects like anorexia and hair loss in some epileptic patients.
3 citations
,
August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.
April 2024 in “Lečaŝij vrač” Valproic acid can cause low platelet counts, especially at high doses or in elderly patients.
7 citations
,
March 2018 in “Psychiatry and Clinical Psychopharmacology” Valproate can cause brain swelling with high ammonia levels, possibly underreported, especially in psychiatric patients.
January 2025 in “Dusunen Adam The Journal of Psychiatry and Neurological Sciences” 59 citations
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October 1976 in “BMJ” Sodium valproate can cause low platelet count.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
1 citations
,
September 2007 in “Neuromuscular disorders” The treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may improve muscle strength in children with SMA without significant side effects.
2 citations
,
September 2015 in “Türk pediatri arşivi : İstanbul çocuk kliniği dergisi” Valproic acid can very rarely cause nail separation, which usually gets better on its own after stopping the drug.