170 citations
,
June 1974 in “BMJ” Sodium valproate effectively reduces seizures in epilepsy, especially in absences and myoclonic types, with minimal side effects.
64 citations
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March 1989 in “PubMed” Valproate is effective for epilepsy but has side effects and requires careful monitoring.
44 citations
,
December 1975 in “Developmental Medicine & Child Neurology” Sodium valproate effectively controls petit mal seizures in children but is less effective for other types, with minimal side effects.
294 citations
,
February 1994 in “PubMed” Valproic acid is an effective and safe first-choice treatment for many types of seizures.
17 citations
,
October 1980 in “PubMed” Valproic acid is effective for controlling seizures in children, especially as a single treatment, with some side effects.
1 citations
,
December 1982 in “PubMed” Sodium valproate effectively reduces seizures in children with epilepsy, especially in primary generalized cases.
Sodium valproate improved epilepsy control in most children but often caused weight gain and other mild side effects.
59 citations
,
October 1976 in “Acta Neurologica Scandinavica” Sodium valproate reduced seizures in many patients with resistant epilepsy.
2 citations
,
June 1986 in “Journal of Clinical Pharmacy and Therapeutics” Metal binding to sodium valproate may be linked to hair loss in epilepsy patients.
111 citations
,
February 1991 in “Headache The Journal of Head and Face Pain” Valproate significantly improved headaches in two-thirds of patients.
2 citations
,
November 1978 in “JAMA” Valproic acid is an effective seizure medication with some temporary side effects.
7 citations
,
September 2007 Valproate sustained-release is effective and generally safe for short-term treatment of new partial epilepsy.
January 2004 in “Headache” Divalproex sodium significantly improved headaches in two-thirds of patients.
24 citations
,
November 1978 in “JAMA” Valproic acid is effective for various seizures, but may cause temporary side effects like drowsiness and stomach issues.
29 citations
,
March 1987 in “Therapeutic Drug Monitoring” Combining sodium valproate with other epilepsy drugs increases ammonia levels and side effects.
13 citations
,
October 2010 in “Seizure” Extended-release valproate effectively reduced seizures and improved quality of life in epilepsy patients over 6 months, with some side effects.
September 2018 in “Practical diabetes” Sodium valproate is not recommended as a first-line treatment for neuropathy but may be used in resistant cases.
August 2018 in “Online journal of neurology and brain disorders” Sodium valproate is effective in treating epilepsy, especially in patients who don't respond to other medications.
January 2011 in “Arqueología, historia y viajes sobre el mundo medieval/Arqueología, historia y viajes sobre el mundo medieval” Sodium valproate can cause severe liver disease and side effects, sometimes leading to death.
Levetiracetam and valproate sodium both reduce seizures when added to lamotrigine, but levetiracetam has fewer side effects.
June 2023 in “International Journal of Pharmaceuticals Nutraceuticals and Cosmetic Science” New information shows Valproate may protect the brain and reduce breathing failure risk but can cause liver damage and other side effects, with genetics affecting dosage needs.
73 citations
,
January 1980 in “Annals of Neurology” Valproic acid can cause serious side effects, including pancreatitis and even death.
169 citations
,
August 1981 in “BMJ” Sodium valproate improved epilepsy control but often caused weight gain in children.
21 citations
,
April 2011 in “Epilepsia” The drug combination significantly reduced epileptic drop attacks in patients.
4 citations
,
January 2019 in “PubMed” Low dose valproate in epileptic children mainly causes weight gain and other non-life-threatening side effects.
July 2020 in “Scholars journal of applied medical sciences” Sodium valproate caused vomiting, hair loss, loss of appetite, abdominal pain, weight gain, and anemia in young children with epilepsy.
16 citations
,
October 1994 in “PubMed” Sodium valproate is a safe and effective epilepsy drug with manageable side effects.
18 citations
,
January 2009 in “Acta neurologica Scandinavica” Long-term sodium valproate treatment for epilepsy generally caused mild and temporary side effects.
2 citations
,
September 2014 in “International Journal of Dermatology” Sodium valproate can worsen psoriasis-like skin conditions.
3 citations
,
August 2023 in “The Journal of Pediatrics” Sodium valproate can rarely cause skin darkening, which may improve after stopping the drug.