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GlossaryMarie Unna Hereditary Hypotrichosis

rare genetic disorder causing sparse or absent hair growth

Marie Unna Hereditary Hypotrichosis (MUHH) is a rare genetic disorder characterized by abnormal hair growth, leading to sparse or absent hair on the scalp and other parts of the body. It is inherited in an autosomal dominant pattern, meaning only one copy of the altered gene is necessary for the condition to manifest.

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A Newly Identified Missense Mutation of the HR Gene Is Associated with a Novel, Unusual Phenotype of Marie Unna Hereditary Hypotrichosis 1 Including Limb Deformities

research A newly identified missense mutation of the HR gene is associated with a novel, unusual phenotype of Marie Unna Hereditary Hypotrichosis 1 including limb deformities

6 citations , May 2012 in “Archives of Dermatological Research”

A new mutation in the HR gene is linked to a rare form of hair loss with limb deformities.

research Marie Unna hereditary hypotrichosis: Identification of a U2HR mutation in the family from the original 1925 report

14 citations , April 2011 in “Journal of the American Academy of Dermatology”

Researchers found a gene mutation responsible for a rare hair loss condition.

research Marie‐Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

12 citations , March 2011 in “Pediatric dermatology”

An 18-year-old girl was diagnosed with a rare hereditary hair loss condition, despite no family history.

research Marie-unna hereditary hypotrichosis

4 citations , January 2014 in “International Journal of Trichology”

A 12-year-old boy with a rare genetic condition has progressive hair loss with no effective treatment.

research Identification of a novel heterozygous mutation in the first Japanese case of Marie Unna hereditary hypotrichosis

6 citations , January 2013 in “The Journal of Dermatology”

Researchers found a new genetic mutation causing a rare hair loss condition in the first Japanese child studied.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research Marie Unna hereditary hypotrichosis caused by a novel mutation in the human hairless transcript

14 citations , July 2010 in “Experimental Dermatology”

A new mutation in the HR gene causes hair loss in a specific family.

Significant Hair Regrowth With 5% Topical Minoxidil in a Child With Marie Unna Hereditary Hypotrichosis Caused by a Recurrent HRURF Variant

research Significant Hair Regrowth With 5% Topical Minoxidil in a Child With Marie Unna Hereditary Hypotrichosis Caused by a Recurrent HRURF Variant

August 2025 in “Journal of Cosmetic Dermatology”

5% topical minoxidil can significantly improve hair growth in children with Marie Unna hereditary hypotrichosis.

research A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family

36 citations , October 2000 in “British Journal of Dermatology”

A different gene near the hairless gene on chromosome 8p21 causes a rare hair loss condition in a German family.

research [Congenital hereditary hypotrychosis. Generalized autosomal dominant hypotrichosis with pili torti (hypotrichosis congenita hereditaria Marie Unna)].

5 citations , November 1979 in “PubMed”

A hereditary condition causes hair loss and twisted hair in some family members.

research Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a U2HR mutation

11 citations , September 2010 in “American Journal of Medical Genetics - Part A”

A Turkish family with sparse hair and eyebrow loss has a mutation in the U2HR gene linked to Marie Unna hereditary hypotrichosis.

research A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis

21 citations , June 2009 in “Mammalian genome”

A new mutation in the Hr gene causes hair loss in mice, similar to a human hair disorder.

research Marie‐Unna Hereditary Hypotrichosis or Autosomal Recessive Hereditary Hypotrichosis with Woolly Hair: The Diagnostic Dilemma of Labeling Cases with Hypotrichosis

2 citations , November 2011 in “Pediatric dermatology”

research Marie‐Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

November 2011 in “Pediatric dermatology”

Marie-Unna Hereditary Hypotrichosis is a rare genetic condition causing sparse hair growth, requiring specific recognition for proper care.

research Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless

29 citations , March 2000 in “Journal of Investigative Dermatology”

The gene for Marie Unna hereditary hypotrichosis is located on chromosome 8p21.

research Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report

May 2018 in “European Journal of Dermatology”

The first Japanese family with Marie Unna hereditary hypotrichosis showed hair condition improvement in a child and highlighted the risk of misdiagnosis.

research Two females with hair loss

July 2019 in “Journal der Deutschen Dermatologischen Gesellschaft”

A mother and daughter have a rare genetic hair loss disorder with no effective treatment.

research Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless

4 citations , March 2000 in “Journal of Investigative Dermatology”

The gene for Marie Unna hereditary hypotrichosis is located on chromosome 8p21, near the hairless gene.

research Polarized microscopy in genetic hair disorders: case series

January 2025

Polarized microscopy helps identify hair irregularities in genetic disorders.

research Clinical and molecular genetic studies in hereditary hair loss

August 2021

Researchers found a genetic link for hereditary hair loss but need more analysis to identify the exact gene.

research Odd-Looking Hair and Progressive Alopecia in Mother and Son

May 2014 in “JAMA Dermatology”

Mother and son diagnosed with a rare genetic hair loss condition with no effective treatment.

research Molecular Basis of Hereditary Hair Diseases

July 2023 in “The Keio Journal of Medicine”

Certain gene variants can cause inherited hair diseases, which are important to diagnose and understand for patient care.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research The genetics of hair shaft disorders

59 citations , June 2008 in “Journal of The American Academy of Dermatology”

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

research Office Diagnosis of Hair Shaft Defects

33 citations , March 2006 in “Seminars in cutaneous medicine and surgery”

The document explains how to identify different hair problems using a microscope.

research The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

2 citations , May 2022 in “Stem cell research & therapy”

Disrupted stem cell signals in hairpoor mice cause hair loss.

research Inherited Disorders of the Hair

2 citations , January 2013 in “Elsevier eBooks”

The document explains the genetic causes and characteristics of inherited hair disorders.

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Related Terms

Research

research A newly identified missense mutation of the HR gene is associated with a novel, unusual phenotype of Marie Unna Hereditary Hypotrichosis 1 including limb deformities

research Marie Unna hereditary hypotrichosis: Identification of a U2HR mutation in the family from the original 1925 report

research Marie‐Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

research Marie-unna hereditary hypotrichosis

research Identification of a novel heterozygous mutation in the first Japanese case of Marie Unna hereditary hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

research Marie Unna hereditary hypotrichosis caused by a novel mutation in the human hairless transcript

research Significant Hair Regrowth With 5% Topical Minoxidil in a Child With Marie Unna Hereditary Hypotrichosis Caused by a Recurrent HRURF Variant

research A distinct gene close to the hairless locus on chromosome 8p underlies hereditary Marie Unna type hypotrichosis in a German family

research [Congenital hereditary hypotrychosis. Generalized autosomal dominant hypotrichosis with pili torti (hypotrichosis congenita hereditaria Marie Unna)].

research Marie Unna hereditary hypotrichosis: A Turkish family with loss of eyebrows and a U2HR mutation

research A novel mutation in Hr causes abnormal hair follicle morphogenesis in hairpoor mouse, an animal model for Marie Unna Hereditary Hypotrichosis

research Marie‐Unna Hereditary Hypotrichosis or Autosomal Recessive Hereditary Hypotrichosis with Woolly Hair: The Diagnostic Dilemma of Labeling Cases with Hypotrichosis

research Marie‐Unna Hereditary Hypotrichosis: Case Report and Review of the Literature

research Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless

research Clinical course of the first Japanese family with Marie Unna hereditary hypotrichosis: a follow-up report

research Two females with hair loss

research Marie Unna Hereditary Hypotrichosis Gene Maps to Human Chromosome 8p21 Near Hairless

research Polarized microscopy in genetic hair disorders: case series

research Clinical and molecular genetic studies in hereditary hair loss

research Odd-Looking Hair and Progressive Alopecia in Mother and Son

research Molecular Basis of Hereditary Hair Diseases

research Biology and Genetics of Hair

research Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA

research Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity

research Differential diagnosis of hair loss in children. Differentialdiagnose des Haarausfalls bei Kindern

research The genetics of hair shaft disorders

research Office Diagnosis of Hair Shaft Defects

research The stem cell quiescence and niche signaling is disturbed in the hair follicle of the hairpoor mouse, an MUHH model mouse

research Inherited Disorders of the Hair