August 2018 in “Pediatric Dermatology” A baby had a unique skin condition with a pale patch and surrounding dark hairs, not linked to other health issues.
Keratinocytes can reduce the survival of certain melanoma cells, suggesting new therapy paths.
7 citations
,
July 2020 in “Dermatologic therapy” Premature graying of hair is linked to various health issues and can sometimes be reversed by treating underlying conditions.
6 citations
,
November 2017 in “Journal of the European Academy of Dermatology and Venereology” A woman got melanoma on her scalp after anti-hair loss treatment with injections.
5 citations
,
July 2009 in “Clinical and experimental dermatology” 21 citations
,
February 2006 in “Clinical Cancer Research” Mitf plays a key role in melanoma progression and is linked to disease stage.
March 2007 in “International Journal of Cosmetic Science” Hair with more melanin resists weather damage better.
2 citations
,
January 1973 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” Brown skin in guinea pigs has more ascorbic acid and related enzymes, black skin uses ascorbic acid well, and white skin has the most protein.
The document concludes that dermatology training and grading scales need to better represent dark-skinned individuals to improve diagnosis and assessment of skin conditions.
7 citations
,
January 2008 in “Indian Journal of Dermatology” Pigmentary mosaicism causes skin color changes and can affect multiple body systems, but has no cure.
1 citations
,
April 2008 in “Pigment Cell & Melanoma Research” Foxn1 is essential for hair pigmentation by directing pigment transfer to hair cells.
January 2004 in “Linchuang pifuke zazhi” All-trans retinoic acid helps amelanotic melanocytes in hair follicles develop and produce pigment while reducing their growth.
15 citations
,
June 2021 in “International Journal of Molecular Sciences” CMC2.24 and CMC2.23 reduce melanin safely and effectively.
7 citations
,
January 2020 in “Nature” Stress turns hair white by depleting color-giving cells in hair follicles through a specific neurotransmitter related to the body's stress response.
30 citations
,
December 2001 in “Experimental dermatology” Gonadal hormones significantly affect the severity of alopecia areata in mice.
April 2025 in “Turkish Journal of Hematology”
1 citations
,
March 2019 in “Chinese Medical Journal” Researchers identified potential markers for human hair color stem cells.
Hair can naturally regain color, and stress might influence greying and its reversal.
29 citations
,
January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” P-cadherin is crucial for hair follicle pigmentation but not skin pigmentation.
4 citations
,
February 2025 in “Pharmaceuticals” Voglibose may help treat skin hyperpigmentation safely.
6 citations
,
August 2022 in “Journal of Herbal Medicine” Mangosteen extract may help with hair growth and prevent graying.
17 citations
,
May 2018 in “Journal of Biomedical Optics” Certain types of human hair might help ultraviolet rays reach and damage cells, possibly leading to melanoma.
130 citations
,
December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair follicle melanocytes die during hair regression.
14 citations
,
May 2022 in “Animals” Female goslings have darker feathers than males due to more melanin.
7 citations
,
July 2017 in “Australasian Journal of Dermatology” Reflectance confocal microscopy is useful for diagnosing scalp melanomas, which have features similar to those on the trunk.
16 citations
,
September 1999 in “Journal of Investigative Dermatology Symposium Proceedings”
21 citations
,
November 2011 in “Veterinary Pathology” Mouse skin color ranges from pink to black, depending on their hair growth cycle.
September 1973 in “Primates” November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
May 2021 in “Open Access Macedonian Journal of Medical Sciences” People with premature hair graying have an imbalance between harmful and protective molecules in their body, hinting that antioxidants might help.