October 2014 in “Transfusion Clinique et Biologique” Iron deficiency can cause fatigue, exercise intolerance, and cognitive issues, even without anemia.
5 citations
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January 2021 in “Daru” A woman had severe reactions to methotrexate, including skin issues and organ problems, but improved after 38 days in the hospital.
January 2010 in “Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine” A unique gene mutation was found in a family with monilethrix.
35 citations
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December 2014 in “Clinical and experimental dermatology” Oxidative stress may play a role in causing alopecia areata.
1 citations
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January 2003 in “Expert Opinion on Therapeutic Patents” Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
382 citations
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February 2010 in “Archives of Internal Medicine” A manufacturing error in a dietary supplement caused severe selenium poisoning, affecting many people and highlighting the need for stricter quality control.
4 citations
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December 1962 in “European journal of endocrinology” Alloxan diabetes, methylthiouracil, cortisone, and adrenaline affect how white mice hair follicles use glucose and cystine and their cell division.
6 citations
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January 1988 in “PubMed” Swimming in pools with high copper can turn hair green, especially if hair is damaged.
2 citations
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January 2011 Zinc deficiency may contribute to alopecia areata and vitiligo.
138 citations
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December 1976 in “Journal of Biological Chemistry” The enzyme from human skin can cross-link proteins and needs calcium to work.
Retinoids can help treat skin pigmentation disorders by affecting melanin production.
January 2013 in “Victoria University Research Repository (Victoria University)” An elemental database for Chinese herbal remedies was created to explore the role of inorganic species in medicine.
June 2025 in “British Journal of Dermatology” Consider amyloidosis in patients with specific nail changes and check for systemic issues.
27 citations
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May 2011 in “Journal of Investigative Dermatology” TCHHL1 is a protein important for hair growth, found in hair follicles.
8 citations
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May 2017 in “IUBMB life” Astrotactin proteins are important for brain and skin development and are linked to several neurodevelopmental disorders.
1 citations
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July 2020 in “The Egyptian Journal of Hospital Medicine” The MDR1 C3435T polymorphism does not significantly affect methotrexate response in rheumatoid arthritis patients.
61 citations
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September 1970 in “Journal of the American Geriatrics Society” Anabolic steroids may help prevent aging effects by reducing toxicity, not by their usual functions.
1 citations
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January 2025 in “Regenerative Biomaterials” Exosomes from Pinctada martensii mucus can safely reduce melanin production, offering a new treatment for skin pigment issues.
15 citations
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September 1970 in “Journal of Animal Science” Copper in the diet helps maintain hair color and mineral balance in calves.
8 citations
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February 2007 in “Journal of The American Academy of Dermatology” Higher serum ferritin levels than currently used might be needed to rule out iron deficiency in women with hair loss.
17 citations
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February 2001 in “Journal of the American Academy of Dermatology” Lithium can cause skin changes similar to mycosis fungoides.
3 citations
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April 2020 in “American Journal of Case Reports” A new mutation in the HJV gene was found in a young woman with juvenile hemochromatosis, causing unusual symptoms like secondary hypothyroidism.
4 citations
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January 1976 in “Archives of Dermatological Research” Metabolic disorders can cause hair structure defects and growth issues, but amino acid levels in hair remain normal.
4 citations
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April 1989 in “The Journal of Dermatology” Trichohyalin granules help inner root sheath cells in hair follicles harden by integrating with keratin filaments.
January 2018 in “International journal of medical biochemistry” Women with telogen effluvium have lower levels of iron, folate, and vitamin B12.
72 citations
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May 1993 in “The Journal of Cell Biology” Trichohyalin in sheep hair follicles may help with structure and calcium binding.
January 2026 in “American Journal of Medical Genetics Part A” A new genetic variant causes trichothiodystrophy in two brothers, but their mother may carry it without showing symptoms.
188 citations
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June 1998 in “Molecular cell” Researchers created a mouse with the same mutation as humans with trichothiodystrophy, showing similar symptoms and confirming the condition is due to defects in DNA repair and gene activity.