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Addressing the Missing Components for Appropriate Surveillance of Merkel Cell Carcinoma Patients: Detailed Recurrence Data and an Integrated Risk Analysis Approach

research 578 Addressing the missing components for appropriate surveillance of Merkel cell carcinoma patients: Detailed recurrence data and an integrated risk analysis approach

April 2019 in “Journal of Investigative Dermatology”

Merkel cell carcinoma is most likely to recur within two years of diagnosis, and factors like immune suppression, being over 75, and male sex increase this risk.

research iRhom2 Mutation Leads to Aberrant Hair Follicle Differentiation in Mice

15 citations , December 2014 in “PLoS ONE”

A mutation in the iRhom2 gene causes hairless mice due to abnormal hair follicle development.

research Targeting of Skin Antigen-Presenting Cells

January 2010 in “Journal of Animal Science”

Transcutaneous vaccination using nanoparticles can enhance immune responses and reduce basal cell carcinomas.

research 060 Heterogeneity and lineage development of memory CD8+ T cells after viral infection of skin

July 2022 in “Journal of Investigative Dermatology”

research Pathogenic CD8+ T cells target K71+ Henle’s layer by forming cytolytic immune synapses in Alopecia Areata

April 2026 in “Research Square”

research Idiopathic CD4+ T-lymphocytopenia

27 citations , September 1992 in “The Lancet”

ICL is a condition with low CD4+ T cells like AIDS but not caused by HIV, and normal CD4+ T cell counts may vary between men and women.

research 057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes

July 2024 in “Journal of Investigative Dermatology”

CD8+ T cells expand significantly in alopecia areata, suggesting new treatment targets.

research The abnormal, mis-localizated HR bmh protein associates with members of the protein processing machinery in the cytoplasm

January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

The mutant HR bmh protein mis-localizes in cells, affecting skin and hair development.

research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

37 citations , January 1993 in “Journal of Investigative Dermatology”

research 332 OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

November 2022 in “Journal of Investigative Dermatology”

ILC1-like cells can cause alopecia areata by affecting hair follicles.

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