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GlossaryMHC Class I Polypeptide-Related Sequence B

plays a role in immune response by signaling stressed cells

MHC Class I Polypeptide-Related Sequence B, also known as MICB, is a protein that plays a role in the immune system. It is part of the MHC (Major Histocompatibility Complex) class I family and is involved in the recognition and destruction of infected or cancerous cells by natural killer (NK) cells and certain T cells. This protein is important for the body's ability to detect and respond to cellular stress.

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research MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression

16 citations , September 2006 in “The Journal of Immunology”

MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.

research The Function and Structure of the Skin

4 citations , November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

research Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats

127 citations , March 2016 in “PLoS ONE”

Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of regulatory network for alopecia areata progression and identification of immune monitoring genes based on multiple machine-learning algorithms

3 citations , May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

research Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations , July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

research The JAK/STAT signaling pathway: from bench to clinic

489 citations , November 2021 in “Signal Transduction and Targeted Therapy”

The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.

research Analysis of Protein Interactions by Surface Plasmon Resonance

42 citations , September 2017 in “Advances in protein chemistry and structural biology”

Surface Plasmon Resonance is a useful tool for studying protein interactions and has potential for future technological advancements.

research Clinical Impact of Molecular Diagnostics in Endocrinology

2 citations , January 2002 in “Hormone Research in Paediatrics”

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

research Foxp3 Post-translational Modifications and Treg Suppressive Activity

82 citations , October 2019 in “Frontiers in Immunology”

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

research Annotated Patent Selections

January 2000 in “Expert Opinion on Therapeutic Patents”

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

research Intramembrane Proteolysis of Astrotactins

8 citations , January 2017 in “Journal of Biological Chemistry”

Astrotactin-2 is cleaved in a specific way that helps understand its maturation.

research Clinical perspectives on the age-related increase of immunosuppressive activity

55 citations , April 2022 in “Journal of Molecular Medicine”

Aging and chronic inflammation weaken the immune system, increasing cancer and infection risks.

research Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions

December 2025 in “ADMET & DMPK”

Personalized treatments for hair loss focus on specific genetic and biological pathways.

research A Microarray-Based Analysis Reveals that a Short Photoperiod Promotes Hair Growth in the Arbas Cashmere Goat

40 citations , January 2016 in “PLoS ONE”

Shorter daylight increases hair growth in Cashmere goats.

Immunological Aspects and Gender Bias During Respiratory Viral Infections Including Novel Coronavirus Disease-19 (COVID-19): A Scoping Review

research Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease‐19 (COVID‐19): A scoping review

11 citations , May 2021 in “Journal of Medical Virology”

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways

research Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

27 citations , April 2017 in “British Journal of Dermatology”

Hair loss involves immune responses, inflammation, and disrupted signaling pathways.

research INTERFERONS IN DERMATOLOGY

22 citations , April 1998 in “Dermatologic Clinics”

Interferons are effective for some skin conditions and cancers, but can have side effects and need more research for optimal use.

Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

research Update on the Genetics of Androgenetic Alopecia, Female Pattern Hair Loss, and Alopecia Areata: Implications for Molecular Diagnostic Testing

11 citations , November 2012 in “Seminars in Cutaneous Medicine and Surgery”

Genetic factors affect hair loss, and molecular testing may help predict, diagnose, and treat it.

research Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases

80 citations , April 2018 in “Trends in Molecular Medicine”

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

research Hair follicle stem cells: Walking the maze

165 citations , June 2007 in “European Journal of Cell Biology”

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

research The Hair Follicle as an Estrogen Target and Source

159 citations , July 2006 in “Endocrine Reviews”

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

research Regenerative Medicine Approaches for Engineering a Human Hair Follicle

August 2018

New treatments for hair loss show promise, including plasma, stem cells, and hair-stimulating complexes, but more research is needed to fully understand them.

research 9. Immunology and Genetics

November 2009 in “Medical & surgical dermatology”

The document concludes that Borrelia afzelii causes a skin condition in France, a gene is linked to hair loss in Caucasian women, and various genetic mutations affect skin diseases.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations , January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

All Roads Lead to the Nucleus: Integration of Signaling, Transcription Factor-Mediated, and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

research All Roads Go to the Nucleus: Integration of Signaling/Transcription Factor-Mediated and Epigenetic Regulatory Mechanisms in the Control of Skin Development and Regeneration

January 2018 in “Stem cell biology and regenerative medicine”

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

Alopecia Areata: An Autoimmune Disease Causing Hair Loss

research Alopecia Areata

421 citations , April 2012 in “The New England Journal of Medicine”

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

research Abstracts

October 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

Mice treatments didn't grow hair, a patient treatment may affect immune response, and people with hair loss often feel anxious or depressed.

research Ectodysplasin-A (EDA) Signaling Cross-Talk in Skeletogenesis

March 2026 in “Calcified Tissue International”

The EDA pathway plays a key role in bone development by interacting with other signaling pathways.

research Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review

7 citations , June 2019 in “Cureus”

Fractional lasers and microneedling, combined with topical agents, could potentially treat Alopecia Areata effectively, but more research is needed due to limited data.