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Did you mean MHC class I?

GlossaryMHC class I

present protein fragments to cytotoxic T cells for immune response

MHC class I, or Major Histocompatibility Complex class I, are molecules found on the surface of almost all nucleated cells in the body. They play a crucial role in the immune system by presenting small fragments of proteins (peptides) from inside the cell to cytotoxic T cells. This helps the immune system recognize and destroy infected or cancerous cells.

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Study of Human Leukocyte Antigen in 13 Cases of Familial Frontal Fibrosing Alopecia: CYP21A2 Gene p.V281L Mutation from Congenital Adrenal Hyperplasia Linked to HLA Class I Haplotype HLA-A*33:01; B*14:02; C*08:02 as a Genetic Marker

research Study of Human Leukocyte Antigen ( HLA ) in 13 cases of familial frontal fibrosing alopecia: CYP 21A2 gene p.V281L mutation from congenital adrenal hyperplasia linked to HLA class I haplotype HLA ‐ A33:01 ; B14:02; C*08:02 as a genetic marker

7 citations , January 2019 in “Australasian Journal of Dermatology”

A genetic marker linked to a type of hair loss was found in most patients studied.

research Immune privilege and alopecia areata

4 citations , April 2010 in “Expert review of dermatology”

Restoring immune privilege in hair follicles could help treat certain types of hair loss.

research LB1029 The common fragrance, linalool, promotes core hair follicle pathology events associated with frontal fibrosing alopecia through activating a cognate olfactory receptor in the bulge

July 2024 in “Journal of Investigative Dermatology”

Linalool in fragrances may harm hair follicles and contribute to hair loss.

research Dandruff lesional scalp skin exhibits epidermal T cell infiltration and a weakened hair follicle immune privilege

March 2024 in “International Journal of Cosmetic Science”

Dandruff is linked to increased T cells and weakened immune protection in hair follicles.

Pre-Clinical In-Vitro Assays for High Throughput Screening of Drug Candidates for Protection and Restoration of Immune Privilege in Alopecia Areata

research 1419 Pre-clinical in-vitro assays for high throughput screening of drug candidates for protection and restoration of immune privilege in alopecia areata

April 2023 in “Journal of Investigative Dermatology”

The research developed methods to test drugs that could protect and restore hair follicle protection in a hair loss condition.

research 1432 IL-9/IL-9R signaling as a novel regulator of human hair follicle growth and immune privilege

April 2023 in “Journal of Investigative Dermatology”

IL-9/IL-9R signaling can negatively affect human hair growth and may be a target for treating hair loss conditions.

research ESDR382 - Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?

September 2022

Linalool in personal care products may worsen frontal fibrosing alopecia by damaging hair follicle stem cells and triggering harmful immune responses.

Immunohistochemical Insight Into the Association Between the Collapse of Immune Privilege in the Sweat Gland and Syringotropic Immune Cell Infiltrates in Collagen Diseases

research 259 Immunohistochemical insight into the association between the collapse of immune privilege in the sweat gland and syringotropic immune cell infiltrates in collagen diseases

September 2017 in “Journal of Investigative Dermatology”

The study found that sweat glands normally suppress immune responses, but this is disrupted in certain skin diseases, possibly contributing to their development.

research Two mouse mutations mapped to chromosome 11 with differing morphologies but similar progressive inflammatory alopecia

7 citations , May 2005 in “Experimental Dermatology”

Two mouse mutations cause similar hair loss despite different skin changes.

research MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression

16 citations , September 2006 in “The Journal of Immunology”

MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.

research Probing the Effects of Stress Mediators on the Human Hair Follicle

159 citations , December 2007 in “American Journal of Pathology”

Stress-related substance P may lead to hair loss and negatively affect hair growth.

research 516 Possible role of ILC1 in the pathogenesis of alopecia areata (AA)

3 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

ILC1 cells contribute to hair loss in alopecia areata.

research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

139 citations , October 2005 in “Journal of Investigative Dermatology”

The nail matrix has a reduced immune response, protecting it from autoimmunity.

research Calcitonin gene‐related peptide (CGRP) may award relative protection from interferon‐γ‐induced collapse of human hair follicle immune privilege

47 citations , December 2011 in “Experimental Dermatology”

CGRP may help protect hair follicles from immune system attacks, potentially slowing hair loss.

research Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege?

21 citations , June 2011 in “Investigative Ophthalmology & Visual Science”

Hair follicles could help develop eye treatments by studying immune responses.

research DISRUPTION OF HAIR FOLLICLE IMMUNE PRIVILEGE IN ALOPECIA AREATA: ENIGMATIC MECHANISMS AND EMERGING CONCEPTS

June 2025 in “Academic Medical Journal”

Restoring hair follicle immune privilege may help treat alopecia areata.

Alopecia Areata Susceptibility Variant Identified by MHC Risk Haplotype Sequencing Reproduces Symptomatic Patched Hair Loss in Mice

research Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)”

A gene variant causes patched hair loss in mice, similar to alopecia areata in humans.

research Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis

9 citations , July 2022 in “EMBO molecular medicine”

Blocking certain immune signals can reduce skin damage from radiation therapy.

research Alopecia areata update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research HDL as Therapeutic Tools

January 2019 in “Springer eBooks”

Modified HDL can better deliver drugs and genes, potentially improving treatments and reducing side effects.

research Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss

19 citations , July 2020 in “EBioMedicine”

A gene variant increases the risk of a type of hair loss by affecting hair protein production.

research Human Hair Follicle-Derived Mesenchymal Stromal Cells from the Lower Dermal Sheath as a Competitive Alternative for Immunomodulation

7 citations , January 2022 in “Biomedicines”

Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarriers Controls Chemotherapy-Induced Alopecia Areata

research Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata

3 citations , May 2023 in “International Journal of Molecular Sciences”

A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.

research Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions

December 2025 in “ADMET & DMPK”

Personalized treatments for hair loss focus on specific genetic and biological pathways.

research Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin

105 citations , December 2017 in “Journal of Biological Engineering”

Artificial skin grafts face immune rejection, but stem cells may improve future designs.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges

106 citations , March 2014 in “BioEssays”

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

research Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

research Cholesterol homeostasis: Links to hair follicle biology and hair disorders

25 citations , July 2019 in “Experimental Dermatology”

Cholesterol balance is important for hair health, and problems with it can lead to hair loss conditions.

research Australasian Society for Dermatology Research Meeting, May 2006

October 2007 in “Journal of Investigative Dermatology”

The meeting highlighted the genetic basis of female pattern hair loss and various skin health insights.