research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss is caused by the breakdown of a protein called COL17A1 in hair follicle stem cells.
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180-210 / 1000+ resultsresearch Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts
Reductive stress messes up collagen balance and alters cell signaling in human skin cells, which could help treat certain skin diseases.
research An Investigation of Hair and its Keratin Associated Proteins using Advanced Light Microscopy
Advanced microscopy shows hair damage and keratin proteins' roles, aiding future cosmetic treatments.
research N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting
Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.
research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair
Potassium cyanide treatment changes hair's disulfide bonds, making it more elastic.
research A Correlative Fluorescent and Electron Microscopic Technique for Ultralocalization of Trichocyte Keratins
Researchers developed a new method to clearly see and label hair proteins with minimal errors using advanced freezing and microscopy techniques.
research Raman spectroscopic analysis of L‐phenylalanine and hydrolyzed eggwhite protein penetration into keratin fibers
L-phenylalanine and hydrolyzed eggwhite protein deeply penetrate human hair.
research Topographical and Tribological Characteristics of Asian Human Hair Cuticles
Hair damage increases significantly with higher temperatures and longer heating times.
research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity
Keratin is crucial for skin barrier formation and affects mitochondrial function.
research A methodological exploration of distinguishing hair quality based on hair proteomics
Bleaching damages hair by reducing the quality of keratin and keratin-associated proteins.
research Characterization of nonkeratinous proteins extracted from human hair by permanet wave lotion.
Permanent wave lotion can extract proteins from hair, especially when pH is higher, and repeated treatments or bleaching can damage hair.
research Effect of equilibrium pH on the structure and properties of bleach‐damaged human hair fibers
Hair's structure and properties change with pH; acidic pH maintains strength and less swelling, while alkaline pH increases water content and swelling.
research Cellular Senescence and Aging in Myotonic Dystrophy
Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.
research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation
UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.
research Damage limitation: comparing the impact of polymers on bleached hair, when applied within or as post-bleach treatments
Polymers help reduce damage and improve bleached hair when used during or after bleaching.
research Analysis of Cysteine on the Surface of Hair Fibers with Spectrofluorescence
Cysteine formation on hair indicates damage, best detected at pH 4.5.
research Pathogenesis in pili torti: morphological study
Pili torti hair twists due to uneven outer root sheath cell development.
research Hair Shaft Damage from Heat and Drying Time of Hair Dryer
Using a hair dryer at 15 cm with continuous motion causes less damage than natural drying.
research Mapping the accessibility of the disulfide crosslink network in the wool fiber cortex
Cysteines in wool fibers are accessible and form important disulfide bonds.
research Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.
research Investigations on the penetration of hydrolyzed wheat proteins into human hair by confocal laser-scanning fluorescence microscopy
Hydrolyzed wheat proteins penetrate all hair types effectively.
research Quantifying Polymer Deposition on Hair Fibers by Microfluorometry
Microfluorometry effectively measures how much polymer coats and penetrates hair, useful for evaluating hair products.
research Author response: NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures
NuMA-microtubule interactions are crucial for proper skin structure and hair growth.
research 1299 Live imaging of keratin network in stratum granulosum reveals dynamic cytoskeletal changes during cornification in mice in vivo
The keratin network in mouse skin changes during cornification and affects the skin's protective barrier.
research Hydrogen Sulfide Disturbs Actin Polymerization via S-Sulfhydration Resulting in Stunted Root Hair Growth
Hydrogen sulfide disrupts protein function and root hair growth in plants by modifying proteins.
research Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis
Hair thinning causes stem cell loss through a process involving Piezo1, calcium, and TNF-α.
research Impact of acid (”progressive brush”) and alkaline straightening on the hair fiber: Differential effects on the cuticle and cortex properties
Glyoxylic acid straighteners cause more protein loss but have similar hair strength effects as traditional alkaline straighteners.
research Exploring the Effects of Wetting and Free Fatty Acid Deposition on an Atomistic Hair Fiber Surface Model Incorporating Keratin-Associated Protein 5-1
Damaged hair allows water to penetrate more easily, and fatty acids from shampoos can deposit on hair surfaces.
research β1 Integrins with Individually Disrupted Cytoplasmic NPxY Motifs Are Embryonic Lethal but Partially Active in the Epidermis
Mutations in β1 integrins cause embryonic death but have milder effects on skin.
research Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice
Defective mitochondrial DNA replication causes aging symptoms and increased oxidative damage in mice.