Search

for
Search:

Sort by

Research

30 / 1000+ results

research The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor

4 citations , February 2023 in “International Journal of Stem Cells”

The FTO gene hinders stem cells in hair follicles from becoming pigment cells.

research Syndromic or non-syndromic congenital ichthyosis? A case report of two brothers with ichthyosis but microphthalmia and blindness in only one brother

January 2024 in “SAGE Open Medical Case Reports”

The brothers have congenital ichthyosis, and the older brother's eye issues are due to different genetic mutations.

research Microphthalmic-associated transcription factor integrates melanocyte biology and melanoma progression.

21 citations , February 2006 in “Clinical Cancer Research”

Mitf plays a key role in melanoma progression and is linked to disease stage.

research Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor

33 citations , January 2015 in “Journal of Ginseng Research”

The study investigated the antimelanogenic effects of ginsenoside Rg3 (G-Rg3) from Panax ginseng, known for its antioxidative, antitumorigenic, and anti-inflammatory properties. G-Rg3 significantly inhibited melanin synthesis in normal human epidermal melanocytes and B16F10 cells in a dose-dependent manner by reducing the activity of cellular tyrosinase and the expression of MITF, tyrosinase, and TRP1, while strongly activating ERK. The use of PD98059, an ERK inhibitor, attenuated these effects, indicating that ERK activation is crucial for G-Rg3's antimelanogenic action. The findings suggested that G-Rg3 could be a promising and safe skin-whitening agent, enhancing the cosmetic applications of P. ginseng.

Clinical Case Notes: Retinoblastoma, Microphthalmia, and Chromosome 13q Deletion Syndrome

research Clinical Case Notes. Retinoblastoma, microphthalmia and the chromosome 13q deletion syndrome

6 citations , February 2004 in “Clinical and Experimental Ophthalmology”

The document concludes that careful diagnosis is crucial for chromosome 13q deletion syndrome, tamoxifen can cause reversible eye damage, finasteride may be linked to cataracts, and OCT is useful for diagnosing macular diseases.

research The Peripheral Clock Regulates Human Pigmentation

81 citations , October 2014 in “The journal of investigative dermatology/Journal of investigative dermatology”

Certain genes control the color of human hair by affecting pigment production.

research Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway

70 citations , December 2004 in “Proceedings of the National Academy of Sciences”

BMP signaling affects hair color by interacting with the MC-1R pathway.

research Loss of Msx2 Function Down-Regulates the FoxE3 Expression and Results in Anterior Segment Dysgenesis Resembling Peters Anomaly

22 citations , April 2012 in “The American journal of pathology”

Loss of Msx2 function causes eye development issues similar to Peters anomaly.

Variable Expressivity of Syndromic BMP4-Related Eye, Brain, and Digital Anomalies: A Review of the Literature and Description of Three New Cases

research Variable expressivity of syndromic BMP4-related eye, brain, and digital anomalies: A review of the literature and description of three new cases

7 citations , May 2019 in “European Journal of Human Genetics”

BMP4-related anomalies can cause a wide range of eye, brain, and hand/foot problems, and new cases show this variability.

Optimization of the Method for Culturing Melanocyte Precursors from Hair Follicles and Their Activation by 1,25-Dihydroxyvitamin D3

research Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3

7 citations , August 2013 in “Experimental and Therapeutic Medicine”

1,25-dihydroxyvitamin D3 helps melanocyte precursors from hair follicles grow and produce melanin, aiding vitiligo treatment understanding.

research Pigmentation Effect of Rice Bran Extract in Hair Follicle-Like Tissue and Organ Culture Models

6 citations , October 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine”

Rice bran extract boosts melanin production in hair follicles.

research Lipid‐mediated signalling and melanocyte function

6 citations , March 2009 in “Pigment Cell & Melanoma Research”

A sphingolipid from human placenta may help treat vitiligo by activating melanocyte stem cells.

research Melanogenesis‐promoting effect of Cirsium japonicum flower extract in vitro and ex vivo

4 citations , October 2021 in “International Journal of Cosmetic Science”

Cirsium japonicum flower extract increases melanin production and could help treat depigmentation conditions.

research Melanocytes and Vitiligo (and Hair Graying)

1 citations , January 2014 in “Elsevier eBooks”

Melanocytes produce melanin; their defects cause vitiligo and hair graying, with treatments available for vitiligo.

research Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport

December 2023 in “Journal of ethnopharmacology”

Tribuloside can increase skin pigmentation by enhancing melanin production and distribution.

Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

research Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity

July 2023

The human scalp has different types of pigment cells in hair follicles with varying abilities to produce pigment.

research Sulfated hyaluronan‐containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles

8 citations , March 2019 in “Journal of Biomedical Materials Research Part A”

Sulfated hyaluronan in collagen helps hair follicle cells grow and develop better for skin grafts.

research Differentiation of CD34+ Human Hair Follicle Stem Cells into Functional Melanocytes

1 citations , December 2018 in “IOP conference series. Materials science and engineering”

CD34+ hair follicle stem cells can become melanin-producing cells for treating skin conditions.

research Clinical Case Notes. Tamoxifen optic neuropathy

23 citations , February 2004 in “Clinical and Experimental Ophthalmology”

A boy with chromosome 13q deletion syndrome developed eye cancer, a woman with breast cancer lost vision due to a rare side-effect of her treatment, a man's vision worsened after using a hair loss drug, and two rare disorders were discussed. Optical Coherence Tomography is useful for diagnosing and monitoring these conditions.

research Clinical Case Notes. Intraorbital ophthalmic artery aneurysms

20 citations , February 2004 in “Clinical and Experimental Ophthalmology”

Eye exams are crucial for kids with 13q deletion syndrome, tamoxifen can cause vision loss, Propecia may lead to cataracts, Lipoid Proteinosis causes skin bumps, and OCT is useful for diagnosing macular diseases.

research Clinical Case Notes. Lipoid proteinosis: a rare disorder with pathognomonic lid lesions

13 citations , February 2004 in “Clinical and Experimental Ophthalmology”

A baby boy with 13q deletion syndrome had eye cancer, a woman's vision improved after stopping a breast cancer drug, a man developed cataracts from using Propecia, and a rare skin disorder called Lipoid Proteinosis was discussed. Also, a tool called OCT is useful for diagnosing macular diseases.

research Clinical Case Notes. Propecia-associated bilateral cataract

11 citations , February 2004 in “Clinical and Experimental Ophthalmology”

Taking Propecia might lead to the development of cataracts.

research Clinical Case Notes. Castleman's disease of the lacrimal gland

9 citations , February 2004 in “Clinical and Experimental Ophthalmology”

The document discusses various eye conditions and their treatments, including a rare eye cancer in a baby, vision loss from a cancer drug, cataracts from a baldness treatment, a rare skin disorder, and a specific type of eye disease diagnosed with a special imaging technique.

research Clinical Case Notes. Malignant melanoma in eviscerated eyeball

7 citations , February 2004 in “Clinical and Experimental Ophthalmology”

Finasteride, often used for hair loss, can potentially cause cataracts.

research Clinical Case Notes. Optical coherence tomography of adult-onset foveomacular vitelliform dystrophy

5 citations , February 2004 in “Clinical and Experimental Ophthalmology”

Multiple eye conditions were studied, highlighting the importance of various imaging methods for diagnosis, the vision side effects of drugs tamoxifen and Propecia, and the usefulness of optical coherence tomography for diagnosing and monitoring macular and retinal diseases.

research Hypotrichosis with juvenile macular dystrophy

4 citations , January 2018 in “International Journal of Trichology”

A rare genetic disease causes sparse hair and early blindness due to a gene mutation.

research Homozygous Deletion in CDH3 and Hypotrichosis With Juvenile Macular Dystrophy

15 citations , November 2012 in “Archives of Ophthalmology”

A deletion in the CDH3 gene causes a rare disorder with short hair and vision loss.

research Molecular basis of hypotrichosis with juvenile macular dystrophy in two siblings

30 citations , August 2005 in “British journal of dermatology/British journal of dermatology, Supplement”

A specific gene mutation causes hair loss and potential eye issues, even if vision seems normal.

Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts

research Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts

43 citations , February 2008 in “Journal of cutaneous pathology”

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

research CDH3 gene related hypotrichosis and juvenile macular dystrophy – A case with a novel mutation

9 citations , June 2017 in “American journal of ophthalmology. Case reports”

A new mutation in the CDH3 gene causes hair loss and vision problems in a young girl.