research Ten years of injectable platelet‐rich fibrin
Injectable platelet-rich fibrin has improved healing and regeneration in various medical fields and can be more effective than previous treatments.
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research The role of 3Rs in the age of One Health: where we are and where we’re going
Innovative methods are reducing animal testing and improving biomedical research.
research 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis
The model can effectively test gene functions and drug responses in human skin.
research A Human Folliculoid Microsphere Assay for Exploring Epithelial– Mesenchymal Interactions in the Human Hair Follicle
HFMs can help study hair growth and test potential hair growth drugs.
research The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results
Both mouse and rat models are effective for testing alopecia areata treatments.
research Synthesis of 11α-hydroxyprogesterone hartens
Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
research Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVECs angiogenesis in vitro
Placental cell medium boosts blood vessel growth in lab tests.
research Next generation human skin constructs as advanced tools for drug development
Advanced human skin models improve drug development and could replace animal testing.
research The Polycystic Ovary Syndrome Evolutionary Paradox: a Genome-Wide Association Studies–Based, in silico, Evolutionary Explanation
The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.
research Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts
Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.
research An In Vitro Model for the Morphogenesis of Hair Follicle Dermal Papillae
Scientists created a model using sheep cells to study hair root formation, which can test how different substances affect hair growth.
research Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment
A new method quickly creates controllable cell clusters for tissue engineering and drug testing.
research TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia
The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
research Skin organoids: A new human model for developmental and translational research
Skin organoids are a promising new model for studying human skin development and testing treatments.
research Adipose-Derived Stem/Stromal Cells
Fat tissue stem cells show promise for repairing different body tissues and are being tested in clinical trials.
research Morphological characteristics and notes of the skin in preclinical toxicity assessment
Skin structure complexity and variability are crucial for assessing skin toxicity in safety tests.
research What should it take to describe a substance or product as 'sperm-safe'
Products should be called 'sperm-safe' only after thorough, well-designed tests.
research Establishment of an in vitro organoid model of dermal papilla of human hair follicle
Researchers developed a 3D model of human hair follicle cells that can help understand hair growth and test new hair loss treatments.
research Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy–like Autoimmune Disease
AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.
research Hair cell toxicology: With the help of a little fish
Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.
research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays
The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
research Alopecia areata in childhood
Alopecia areata is relatively common in children, has a variable course, and shows different responses to treatment; thyroid testing is recommended for those affected.
research Engineering immune-competent hair follicle microphysiological systems: from organoid assembly to dynamic immune modelling
Hair follicle systems are being engineered to better mimic natural hair follicles for studying hair disorders and testing treatments.
research Why Do Promising Therapies Stall in Development and How Can We Move Them Forward?
Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.
research Anticancer drugs in surface waters
Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.
research Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19
Cepharanthine, a Japanese hair loss drug, shows promise as a COVID-19 treatment but needs more testing.
research Drug eruptions in dermatology
Skin reactions to drugs are common and can be deadly, usually requiring stopping the drug and may be better prevented with genetic testing in the future.
research Therapeutic strategies for treating hair loss
The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
research Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis
The model helps test drugs for clubfoot fibrosis by mimicking cell environments and shows minoxidil reduces harmful collagen links.
research Cell-Based Model Systems for Validation of Various Efficacy-Based Claims for Cosmetic Ingredients
Cell-based models help test if cosmetic ingredients really work for hair growth and skin health.