Search

for
Search:

GlossaryMineralocorticoid Receptor

protein that regulates salt and water balance in cells

The Mineralocorticoid Receptor (MR) is a type of protein found inside cells that binds to mineralocorticoids, such as the hormone aldosterone. This receptor plays a crucial role in regulating the balance of salt and water in the body by influencing kidney function. When activated, it helps control blood pressure and fluid balance, making it important for both everyday health and in conditions like hypertension and heart failure.

Related Terms

Sort by

Research

30 / 518 results

Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

research Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia

67 citations , August 2007 in “American Journal of Pathology”

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

research The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon?

40 citations , November 2009 in “Experimental Dermatology”

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

research The Acute Anticonvulsant Effects of Deoxycorticosterone in Developing Rats: Role of Metabolites and Mineralocorticoid‐receptor Responses

13 citations , November 2005 in “Epilepsia”

Deoxycorticosterone and its metabolites help prevent seizures by interacting with specific receptors.

research The mineralocorticoid receptor plays a transient role in mouse skin development

12 citations , August 2015 in “Experimental Dermatology”

The mineralocorticoid receptor temporarily affects mouse skin development, but the glucocorticoid receptor has a more lasting impact.

research Association between Mineralocorticoid Receptor Antagonist and Mortality in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis

10 citations , March 2022 in “Healthcare”

Mineralocorticoid receptor antagonist therapy does not significantly reduce mortality in COVID-19 patients.

research The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid‐induced impaired wound healing

9 citations , July 2022 in “British Journal of Pharmacology”

Blocking the mineralocorticoid receptor improves wound healing by reducing inflammation and promoting blood vessel growth.

Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

research Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing

9 citations , June 2021 in “International Journal of Pharmaceutics”

Using polymeric micelles to deliver spironolactone topically could improve wound healing in skin affected by glucocorticoids.

research Mineralocorticoid Receptor Antagonists—A New Sprinkle of Salt and Youth

8 citations , October 2016 in “Journal of Investigative Dermatology”

MR antagonists may improve skin health and wound healing, especially in aging.

research A novel actor in skin biology: the mineralocorticoid receptor

7 citations , October 2015 in “Experimental dermatology”

Blocking the mineralocorticoid receptor can help treat skin thinning caused by steroids.

research Mineralocorticoid Receptor Antagonists Stimulate Human Hair Growth ex vivo

1 citations , January 2019 in “Skin Pharmacology and Physiology”

Eplerenone, a mineralocorticoid receptor antagonist, was found to promote hair growth in human hair follicles.

research Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia.

August 2007 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

Overexpression of a specific receptor in mice skin causes skin thinning, early skin barrier formation, eye issues, and hair loss.

research SARS-CoV-2 Spike Protein S1-Mediated Endothelial Injury and Pro-Inflammatory State Is Amplified by Dihydrotestosterone and Prevented by Mineralocorticoid Antagonism

50 citations , November 2021 in “Viruses”

Spironolactone may help reduce COVID-19 severity in men by blocking harmful effects of certain hormones.

research Roles of steroid receptors in the lung and COVID-19

9 citations , July 2021 in “Essays in Biochemistry”

Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.

research Glucocorticoid and Sex Hormone Receptors: Clinical Implications and Therapeutic Relevance

4 citations , October 2007 in “Dermatologic Clinics”

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

research The Glucocorticoid Resistance Syndrome. Two Cases of a Novel Pathogenic Variant in the Glucocorticoid Receptor Gene

December 2023 in “JCEM case reports”

A new gene variant causes glucocorticoid resistance in a mother and son.

research Pharmacology of different progestogens: the special case of drospirenone

104 citations , January 2005 in “Climacteric”

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

research Chrousos syndrome: from molecular pathogenesis to therapeutic management

47 citations , February 2015 in “European Journal of Clinical Investigation”

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

research Association of androgenetic alopecia and hypertension.

34 citations , August 2007 in “PubMed”

Balding in men is strongly linked to high blood pressure and family history.

research Oral medications for central serous chorioretinopathy: a literature review

14 citations , September 2019 in “Eye”

Some oral medications may help treat central serous chorioretinopathy, especially eplerenone, but more research is needed.

research Current Therapeutic Approaches to Chronic Central Serous Chorioretinopathy

13 citations , February 2019 in “Türk oftalmoloji dergisi”

New treatments for chronic central serous chorioretinopathy show promise in preventing permanent vision loss.

Steroid Hormones: Overview and Medical Applications

research Steroid Hormones

3 citations , January 2016 in “Elsevier eBooks”

Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.

research Case report: A pregnant woman accidental treated with spironolactone in mid-gestation

1 citations , July 2024 in “Frontiers in Pharmacology”

The woman delivered a healthy baby boy despite taking spironolactone during pregnancy.

research Disruption of androgen metabolism, regulation and effects : involvement of steroidogenic enzymes

January 2014 in “edoc (University of Basel)”

Anabolic steroids and inflammation can disrupt androgen metabolism, potentially causing health issues.

research Spironolactone

February 2024 in “Practical Diabetes”

Spironolactone helps reduce hospital visits and death from heart issues, lowers blood pressure, but has unclear effects on heart failure with normal heart pump function and can cause high potassium and breast enlargement in men.

research Atualização em Coriorretinopatia Serosa Central

January 2016 in “e-Oftalmo CBO Revista Digital de Oftalmologia”

CSC is linked to mineralocorticoid receptor damage, stress, and steroid use, with treatments including drugs and laser therapies to prevent eye damage.

research Abiraterone and spironolactone in prostate cancer: a combination to avoid

9 citations , November 2018 in “Acta Clinica Belgica”

Don't combine abiraterone and spironolactone for prostate cancer treatment as it may worsen the disease.

research Profile of the progesterone derivative chlormadinone acetate — Pharmocodynamic properties and therapeutic applications

33 citations , January 2009 in “Contraception”

Chlormadinone acetate is a strong, well-tolerated hormone used in birth control and hormone therapy with benefits for menstrual pain and skin conditions.

research Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor

December 2016 in “Springer eBooks”

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching Is an Integrated Measure of Receptor Function

research Glucocorticoid Receptor Mutants Demonstrate Increased Motility Inside the Nucleus of Living Cells: Time of Fluorescence Recovery After Photobleaching (FRAP) Is an Integrated Measure of Receptor Function

31 citations , July 2004 in “Molecular Medicine”

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

research Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

25 citations , June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.