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Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

12 citations , February 2014 in “PLoS ONE”

Topical rapamycin may effectively treat fibrous papules on the face.

research ANXA1 affects murine hair follicle growth through EGF signaling pathway

5 citations , December 2020 in “Gene”

ANXA1 influences hair growth in mice through the EGF signaling pathway.

research Template‐directed self‐assembly and growth of insulin amyloid fibrils

36 citations , March 2005 in “Biotechnology and Bioengineering”

A new method speeds up insulin amyloid fibril growth, useful for studying diseases.

research Androgen receptor signaling as a new target for intervention in acute myeloid leukemia

September 2025 in “Blood Advances”

Targeting androgen receptor signaling may improve acute myeloid leukemia treatment.

Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands

research Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands

6 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

research In vitro effect of diammonium glycyrrhizinate on the growth of human hair follicles and Wnt/β-catenin signaling pathway

February 2018 in “Chinese Journal of Dermatology”

Diammonium glycyrrhizinate at 0.01 μmol/L promotes hair growth by activating the Wnt/β-catenin pathway.

research The SH-1 Molecule By Dr. Melvin Sewell

June 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

SH-1 effectively treats hair loss without side effects.

research Sub-chronic testosterone treatment increases the levels of epithelial sodium channel (ENaC)-α,βandγin the kidney of orchidectomized adult male Sprague–Dawley rats

18 citations , June 2016 in “PeerJ”

Testosterone increases certain kidney protein levels, potentially raising blood pressure.

research The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research^*

88 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

research The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response

23 citations , March 1994 in “Fertility and sterility”

Most patients improved with oral contraceptives, but some needed additional treatment.

research Image1.TIF

December 2021

GPC1 is important for blood vessel growth in hair follicles and could help treat hair loss.

research Testosterone, cytochrome P450, and cardiac hypertrophy

155 citations , October 2002 in “The FASEB Journal”

Heart-specific steroid metabolism is crucial in cardiac hypertrophy.

research Melanocortin receptors in fibroblastic cell types of the skin –in vitro and in vivo expression and functional relevance

1 citations , September 2004 in “Experimental Dermatology”

MC-1R is present in skin cells and may help reduce inflammation.

research Compound glycyrrhizin promotes hair growth in C57BL/6 mice by regulating the Wnt/β-catenin pathway

July 2025 in “Dermatologica Sinica”

Glycyrrhizin may help regrow hair by activating a specific pathway.

research Severe steroid-dependent idiopathic angioedema with response to rituximab

16 citations , August 2011 in “Annals of Allergy Asthma & Immunology”

A woman with severe angioedema improved significantly after treatment with rituximab.

research The SH-1 Molecule By Dr. Melvin Sewell

June 2026 in “HAL (Le Centre pour la Communication Scientifique Directe)”

SH-1 effectively treats hair loss without side effects.

Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid, and Carnitine-Containing Compound in Prostate and Hair Follicle Cell-Based Assays

research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays

3 citations , March 2016 in “Phytotherapy Research”

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.

research PC-SPES Studies Promising, But Manufacturer Shuts Down

September 2002 in “Oncology Times”

Promising cancer treatments were found, but the manufacturer closed.

research Matrigel uses in cell biology and for the identification of thymosin β4, a mediator of tissue regeneration

15 citations , September 2018 in “Applied Biological Chemistry”

Matrigel supports cell growth and repair, and thymosin beta 4 aids tissue regeneration and healing.

research 266 Myristoylphorbol Acetate (MPA) Enhances Metastasis Via Up-regulation of Eph A2 Transcription Activity

July 2012 in “European journal of cancer”

MPA increases cancer spread by boosting Eph A2 activity.

research Cytokine Engineering Approaches for Regenerative Medicine

3 citations , August 2025 in “Advanced Therapeutics”

Engineered cytokines show promise for improving tissue healing and safety in regenerative medicine.

research The β‐thymosins: Intracellular and extracellular activities of a versatile actin binding protein family

110 citations , April 2009 in “Cell Motility and the Cytoskeleton”

β‐thymosins, especially thymosin β4, help in heart protection, wound healing, and hair growth by stabilizing actin in cells.

research 710 BIOMARKERS OF SUNITNIB CLINICAL RESPONSE IN METASTATIC RENAL CLEAR CELL CARCINOMA PATIENTS

March 2009 in “European Urology Supplements”

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Rat hair-follicle-associated pluripotent (HAP) stem cells can differentiate into atrial or ventricular cardiomyocytes in culture controlled by specific supplementation

January 2024 in “PloS one”

Rat hair-follicle stem cells can become heart cells with specific supplements.

research Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids

19 citations , October 2022 in “The Ocular Surface”

research Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells

2 citations , September 2024 in “PLoS ONE”

Bendamustine combined with tucidinostat may effectively treat adult T-cell leukemia.

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Research

research Fibrous Papule of the Face, Similar to Tuberous Sclerosis Complex-Associated Angiofibroma, Shows Activation of the Mammalian Target of Rapamycin Pathway: Evidence for a Novel Therapeutic Strategy?

research ANXA1 affects murine hair follicle growth through EGF signaling pathway

research Template‐directed self‐assembly and growth of insulin amyloid fibrils

research Androgen receptor signaling as a new target for intervention in acute myeloid leukemia

research Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands

research In vitro effect of diammonium glycyrrhizinate on the growth of human hair follicles and Wnt/β-catenin signaling pathway

research The SH-1 Molecule By Dr. Melvin Sewell

research Sub-chronic testosterone treatment increases the levels of epithelial sodium channel (ENaC)-α,βandγin the kidney of orchidectomized adult male Sprague–Dawley rats

research The antiandrogen cyproterone acetate: discovery, chemistry, basic pharmacology, clinical use and tool in basic research^*

research The hyperandrogenic-insulin-resistant acanthosis nigricans syndrome: therapeutic response

research Image1.TIF

research Testosterone, cytochrome P450, and cardiac hypertrophy

research Melanocortin receptors in fibroblastic cell types of the skin –in vitro and in vivo expression and functional relevance

research Compound glycyrrhizin promotes hair growth in C57BL/6 mice by regulating the Wnt/β-catenin pathway

research Severe steroid-dependent idiopathic angioedema with response to rituximab

research The SH-1 Molecule By Dr. Melvin Sewell

research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays

research PC-SPES Studies Promising, But Manufacturer Shuts Down

research Matrigel uses in cell biology and for the identification of thymosin β4, a mediator of tissue regeneration

research 266 Myristoylphorbol Acetate (MPA) Enhances Metastasis Via Up-regulation of Eph A2 Transcription Activity

research Cytokine Engineering Approaches for Regenerative Medicine

research The β‐thymosins: Intracellular and extracellular activities of a versatile actin binding protein family

research 710 BIOMARKERS OF SUNITNIB CLINICAL RESPONSE IN METASTATIC RENAL CLEAR CELL CARCINOMA PATIENTS

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

research Thymosin β4 promotes angiogenesis, wound healing, and hair follicle development

research Pharmacodynamics of minoxidil as a guide for individualizing dosage regimens in hypertension

research Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective

research Rat hair-follicle-associated pluripotent (HAP) stem cells can differentiate into atrial or ventricular cardiomyocytes in culture controlled by specific supplementation

research Induction of meibocyte differentiation by three-dimensional, matrigel culture of immortalized human meibomian gland epithelial cells to form acinar organoids

research Cytotoxicity of bendamustine, alone and in combination with novel agents, toward adult T-cell leukemia cells