April 2023 in “Journal of Investigative Dermatology” Mutations in the SHH pathway in certain skin cells can cause skin tumors and abnormal hair growth.
November 2022 in “Journal of the Endocrine Society” Removing the ovarian tumor improved the woman's hormonal symptoms.
22 citations
,
February 2008 in “Journal of Neurochemistry” Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.
2 citations
,
December 2022 in “Pharmaceutics” The enzyme pyruvate kinase M2 helps hair regrowth and could be a potential treatment for hair loss.
12 citations
,
January 2009 in “Gynecological Endocrinology” A postmenopausal woman's hair loss and excess hair growth improved after surgery for ovarian hyperthecosis.
118 citations
,
February 2009 in “Fertility and Sterility” Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.
5 citations
,
June 2024 in “Developmental Cell” Activating TRPV1 can boost hair growth by involving neurons, macrophages, and fibroblasts.
November 2022 in “Journal of the Endocrine Society” A 21-year-old male with a rare genetic disorder experienced sudden hair loss and high DHEAS levels, likely due to a condition similar to PCOS, usually seen in women.
42 citations
,
September 2007 in “The Journal of Clinical Endocrinology and Metabolism” The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.
January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology” Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.
June 2002 in “Science of aging knowledge environment” The cancer gene c-Myc increases harmful chemicals that damage DNA and can lead to cancer, but antioxidants can reduce this damage.
3 citations
,
May 2002 in “PubMed” The document concludes that treatment for excessive hair growth depends on the cause, with options including hair removal methods and medications like anti-androgens or insulin-sensitizing drugs.
1 citations
,
November 2007 in “Humana Press eBooks” Most cases of high male hormone levels in women are due to polycystic ovary syndrome.
24 citations
,
May 1982 in “Biochemical Pharmacology” These drugs cause hair growth without affecting testosterone or adrenal hormones.
17 citations
,
February 2003 in “Australasian Journal of Dermatology” Hair loss in postmenopausal woman caused by ovarian issue.
December 2025 in “Pediatric Dermatology” Trametinib can cause skin issues, but they can often be managed without stopping the drug.
35 citations
,
March 2012 in “Experimental and Clinical Endocrinology & Diabetes” The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.
23 citations
,
May 2013 in “Virology” HPV16 oncogenes disrupt the normal activity of hair follicle stem cells.
3 citations
,
January 2017 in “Gynecological endocrinology” A postmenopausal woman's excess male hormone symptoms were caused by a rare adrenal gland tissue in her ovary.
19 citations
,
April 2024 in “Nature Cell Biology” 60 citations
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August 2005 in “Endocrinology” αMSH may help regulate immune responses in hair follicles and its disruption could lead to hair loss.
July 2025 in “Journal of Investigative Dermatology” Miniaturized hair follicles in androgenetic alopecia show abnormal mitochondrial activity and damage.
3 citations
,
March 2019 in “Case Reports” A man with myotonic dystrophy type 1 had 28 skin cancers, suggesting a link between the disease and skin cancer, emphasizing the need for sun protection and regular skin checks.
15 citations
,
August 1988 in “Archives of Otolaryngology - Head and Neck Surgery” Minoxidil can cause excessive hair growth in the ear canal, leading to ear infections and hearing loss.
27 citations
,
June 2023 in “Nature” Senescent melanocytes can boost hair growth by activating hair stem cells.
July 2022 in “Journal of Investigative Dermatology” Substance P may contribute to hair loss by increasing oxidative stress and mitochondrial activity in hair follicles.
9 citations
,
November 2013 in “Presse Medicale” The document concludes that managing female hyperandrogenism requires a combination of identifying the cause, lifestyle changes, medication, and cosmetic treatments.
32 citations
,
August 2016 in “Science Signaling” Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.
July 2022 in “Journal of Investigative Dermatology” Inhibiting TYK2 can restore hair growth in alopecia areata.
10 citations
,
March 2022 in “Frontiers in Oncology” HOTTIP and miR-10b contribute to glioma therapy resistance by affecting cell behavior, suggesting they could be targets for treatment.