July 2023 in “International Journal of Molecular Sciences” N,N-Dimethylglycine Sodium Salt helps reduce skin inflammation and improves skin cell growth and healing.
6 citations
,
July 2009 in “Journal of Cutaneous Pathology” Hair follicle stem cells are key for hair growth and skin repair.
90 citations
,
February 2001 in “The journal of investigative dermatology/Journal of investigative dermatology” Interleukin-1 increases keratin K6 production in skin cells.
3 citations
,
September 2024 in “Animal Cells and Systems” Sargassum horneri extract speeds up burn healing and reduces inflammation.
6 citations
,
July 2021 in “International Wound Journal” The biofilm-dispersing wound gel helps wounds heal faster and prevents infection.
1 citations
,
January 2016 in “Elsevier eBooks” The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
21 citations
,
February 2017 in “PLoS ONE” RhoA helps skin stem cells grow, aiding wound healing.
June 2026 in “Preprints.org” Pathological skin scarring, including hypertrophic scars and keloids, arises from dysregulated wound healing processes involving excessive inflammation and mechanical tension, leading to fibroblast differentiation and disorganized collagen deposition. The review identifies key signaling pathways, such as TGF-β/Smad and TNF-α/NF-κB, as therapeutic targets and highlights a novel treatment using atorvastatin delivered via a keratin hydrogel derived from human hair. This approach offers a sustainable, localized anti-fibrotic therapy. Combination therapies are suggested to be more effective than monotherapies, although recurrence remains a challenge. The document also discusses genetic predispositions, various current treatments, and emphasizes the need for further research to optimize therapies for scar-free healing.
November 2023 in “International Journal of Pharmaceutics” New hair loss treatment using marine collagen and dissolvable needles improves hair growth.
175 citations
,
December 2014 in “PLoS Biology” Macrophages help activate hair follicle stem cells, affecting hair growth and skin repair.
July 2023 in “Stem Cells Translational Medicine” Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.
June 2025 in “Cell Metabolism” Serine is vital for hair follicle stem cells to balance hair growth and skin repair.
38 citations
,
February 2021 in “Journal of Investigative Dermatology” Aging slows wound healing due to weaker cells and immune response.
18 citations
,
July 2023 in “International Journal of Molecular Sciences” KY19382 speeds up wound healing by activating a specific cell signaling pathway.
2 citations
,
November 2023 in “Biomolecules” WNT signaling is crucial for skin development and healing.
266 citations
,
January 2016 in “Development” YAP and TAZ are crucial for skin cell growth and repair.
6 citations
,
July 2025 in “Frontiers in Microbiology” Imbalanced skin bacteria worsen diabetic foot ulcers, but adjusting them might improve healing.
119 citations
,
August 2010 in “Journal of Investigative Dermatology” Increased 11β-HSD1 activity in skin may contribute to aging and could be targeted to reduce aging effects.
16 citations
,
January 2023 in “Acta Biomaterialia” The hydrogel quickly stops bleeding and helps heal infected wounds.
2 citations
,
June 2025 in “Chemical Engineering Journal” The hydrogel helps heal seawater-immersed wounds by reducing infection and inflammation.
46 citations
,
July 2022 in “Frontiers in Oncology” Cold atmospheric plasma is a promising and safe treatment for various skin conditions.
1 citations
,
April 2022 in “Regenerative Therapy” Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.
19 citations
,
January 2023 in “Frontiers in Bioengineering and Biotechnology” MSC-sEVs may effectively treat chronic non-healing wounds.
February 2026 in “Molecular and Cellular Probes” Stem cell and plant exosomes may help heal and regenerate skin.
25 citations
,
February 2025 in “Frontiers in Bioengineering and Biotechnology” New skin repair methods show promise but need to be safer and more accessible.
21 citations
,
October 2007 in “Journal of Investigative Dermatology” Fetuin-A helps wounds heal without scars by promoting cell movement.
8 citations
,
July 2024 in “Cells” PGC-1α may improve aging skin by boosting mitochondrial function and reducing inflammation.
1 citations
,
March 2023 in “Phytochemistry Reviews” CBD may improve skin and hair health, but its effective use and safety need more research.
March 2026 in “Preprints.org” The combined stem cell secretome in the skin care product effectively reduces inflammation and promotes tissue regeneration.
July 2025 in “BMC Microbiology” Pancreatic cancer can alter gut and skin bacteria, possibly causing skin issues.