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GlossaryMyeloid Cells

white blood cells originating from bone marrow stem cells

Myeloid cells are a type of white blood cell that originate from bone marrow stem cells. They play a crucial role in the immune system by differentiating into various cell types, including macrophages, neutrophils, and dendritic cells, which help the body fight infections and remove dead cells.

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research Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

301 citations , February 2019 in “Nature Communications”

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

research 974 Single-cell analysis identifies heterogeneity of fibroblasts and myeloid-derived adipocytes in regenerating mouse skin wounds

1 citations , April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Fibroblasts and myeloid cells in mouse skin wounds are diverse and can change into different cell types during healing.

research MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

December 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

MCPIP1 in myeloid cells is important for skin cancer development and healthy hair growth.

research 176 Myeloid cell-specific deletion of mTOR suppresses psoriasis-like skin inflammation in C57BL/6 mice

April 2023 in “Journal of Investigative Dermatology”

Targeting mTOR in myeloid cells may help reduce psoriasis symptoms.

research M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice

December 2021 in “Research Square (Research Square)”

M-CSF-stimulated myeloid cells can cause alopecia areata in mice.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing

June 2022 in “PLOS ONE”

M-CSF-stimulated myeloid cells can turn into skin cells and help heal wounds and regrow hair.

research M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing

December 2021

Myeloid cells can turn into skin and hair cells to help heal wounds.

research Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata

45 citations , June 2018 in “Frontiers in immunology”

MDSC-Exo can treat autoimmune alopecia areata and promote hair regrowth in mice.

research The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema

84 citations , October 2007 in “The Journal of Immunology”

Myeloid-derived suppressor cells help control autoimmune cells and promote hair regrowth in alopecia areata.

research Finasteride Enhances the Generation of Human Myeloid-Derived Suppressor Cells by Up-Regulating the COX2/PGE2 Pathway

10 citations , June 2016 in “PLOS ONE”

Finasteride boosts immune cells that suppress T-cells, possibly helping with immune disorders but may increase cancer risk.

research 413 DC-HIL+ myeloid-derived suppressor cells are elevated in the peripheral blood and lesional skin of cutaneous lupus patients

April 2018 in “Journal of Investigative Dermatology”

Cutaneous lupus patients have higher levels of certain immune cells in their blood and skin.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations , March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

research Immune Cells in Cutaneous Wound Healing: A Review of Functional Data from Animal Models

5 citations , February 2022 in “International Journal of Molecular Sciences”

Different immune cells like platelets, mast cells, neutrophils, macrophages, T cells, B cells, and innate lymphoid cells all play roles in skin wound healing, but more research is needed due to inconsistent results and the complex nature of the immune response.

research LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis

1 citations , July 2024 in “Journal of Investigative Dermatology”

Immune cells boost stem cell activity in hairy moles, causing more hair growth.

research Crosstalk between Immune Microenvironment and Hair Follicle Cells Underlies Sexual Dimorphism in Androgenetic Alopecia

September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Hair loss in males and females is influenced by immune cell interactions, with potential treatments identified.

research 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering

September 2019 in “Journal of Investigative Dermatology”

Researchers developed a 3D skin model with its own immune and blood vessel cells to better understand skin health and disease.

research Plasma proteome–driven identification of druggable immune regulators of alopecia areata, validated by transcriptome and single-cell mapping

March 2026 in “Skin Appendage Disorders”

Belatacept may be a promising treatment for alopecia areata.

research 1374 Cell-cell interaction in the hair follicle niche in androgenetic alopecia

April 2023 in “Journal of Investigative Dermatology”

New drug targets for hair loss treatment were identified by studying cell interactions in hair follicles.

research Attending persistent T cell activation in alopecia areata : A therapeutic option

January 2011 in “Repository KITopen (Karlsruhe Institute of Technology)”

Blocking certain proteins on immune cells may help treat alopecia areata.

research 137 Loss of myeloid Mcpip1 suppresses hair growth and development of epidermal papilloma of the skin

November 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Removing MCPIP1 from myeloid cells in mice leads to hair loss and prevents skin tumors but causes pigmented spots.

research Androgen receptor signaling as a new target for intervention in acute myeloid leukemia

September 2025 in “Blood Advances”

Targeting androgen receptor signaling may improve acute myeloid leukemia treatment.

research Vitiligo and Alopecia Areata After Donor Lymphocyte Infusions in a Child With Relapsed Acute Myeloid Leukemia

January 2024 in “Cureus”

Donor lymphocyte infusions effectively treated leukemia relapse but caused vitiligo and alopecia areata.

research A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation

September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

A parasite-derived molecule speeds up skin healing and affects immune cell behavior without increasing scarring.

research Porphyria Cutanea Tarda in a Patient With Agnogenic Myeloid Metaplasia

5 citations , April 1984 in “Archives of Dermatology”

Porphyria cutanea tarda causes skin issues due to an enzyme deficiency.

research Multifunctional DNA Hydrogels with Hydrocolloid‐Cotton Structure for Regeneration of Diabetic Infectious Wounds

83 citations , September 2021 in “Advanced functional materials”

The DNA hydrogel helps heal diabetic wounds by absorbing fluids, warming, sticking to tissue, killing bacteria, and aiding tissue and hair regrowth.

Helminth TGF-β Mimic, TGM, Increases Leukocyte Migration and Activation While Also Enhancing Cutaneous Wound Healing and Tissue Regeneration

research Helminth TGF-β mimic, TGM, increases leukocyte migration and activation while also enhancing cutaneous wound healing and tissue regeneration.

May 2022 in “Journal of Immunology”

A parasite molecule can speed up skin healing and reduce scarring.