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Novel Lead Generation Through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase

research Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase

27 citations , October 2001 in “Journal of Medicinal Chemistry”

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

research ISIDLB1777 - A novel ex vivo model of human hair follicle immune privilege collapse reveals the potential of farudodstat, a DHODH inhibitor, as a therapeutic for alopecia areata treatment

May 2023

Farudodstat may effectively treat alopecia areata by protecting hair follicles without harmful effects.

research Dual-phase release finasteride-loaded microspheres for androgenetic alopecia treatment: rapid intervention and sustained control of dihydrotestosterone

August 2025 in “International Journal of Pharmaceutics”

A new finasteride treatment may quickly and effectively promote hair regrowth.

research Minoxidil niosome loaded dissolving microneedle delivery system for treatment of DHT induced androgenic alopecia in C57BL/6 Mice

July 2026 in “Journal of Drug Delivery Science and Technology”

research Gum Arabic Enhances Hair Follicle-Targeting Drug Delivery of Minoxidil Nanocrystal Dispersions

December 2024 in “Biological and Pharmaceutical Bulletin”

Gum arabic improves minoxidil delivery to hair follicles, enhancing hair growth.

Suicidal Behaviors (Suicidal Ideation, Suicide Attempt and Completed Suicide) in Patients Treated with Finasteride for Hair Loss: Results from the U.S. FDA Adverse Event Reporting System Database

research Suicidal behaviors (suicidal ideation, suicide attempt and completed suicide) in patients treated with finasteride for hair loss: Results from the U.S. FDA Adverse Event Reporting System (FAERS) database

August 2018 in “Journal of The American Academy of Dermatology”

research Relapsing nail fibrokeratoma: A case report on a teenager

April 2016 in “Journal of The American Academy of Dermatology”

Dutasteride is more effective than finasteride for hair growth with similar side effects.

Comparison of the Efficacy of Niosomal Minoxidil with Conventional Minoxidil in the Treatment of Androgenetic Alopecia: A Randomized, Controlled, Double-Blind Clinical Trial

research Comparison of the efficacy of niosomal minoxidil with conventional minoxidil in the treatment of androgenetic alopecia: A randomized, controlled, double-blind clinical trial

July 2014 in “Journal of Dermatology and Cosmetic”

Niosomal minoxidil was found to be more effective in increasing hair count and patient satisfaction than conventional minoxidil in treating hair loss.

Real-World Effectiveness, Safety, and Tolerability of Cetosomal Minoxidil 5% Alone and in Combination With Finasteride 0.1% in the Management of Androgenetic Alopecia

research Real-World Effectiveness, Safety, and Tolerability of Cetosomal Minoxidil 5% Alone and a Fixed Drug Combination of Cetosomal Minoxidil 5% With Finasteride 0.1% in the Management of Androgenetic Alopecia (Inbilt Study)

1 citations , July 2023 in “Cureus”

Cetosomal minoxidil alone and with finasteride is effective and well-tolerated for hair loss treatment.

research Enzyme-linked immunosorbent assays for doping control of 5α-reductase inhibitors finasteride and dutasteride

10 citations , May 2010 in “Analytica Chimica Acta”

New tests detect finasteride and dutasteride in urine quickly and easily.

research The effects of methylated flavonoids on depression-like activity and pro-inflammatory cytokine thresholds in mice induced by repeated finasteride administration

1 citations , January 2021 in “European Journal of Inflammation”

Methylated flavonoids may effectively reduce depression and inflammation caused by finasteride.

research Determination of Residual Organic Solvents in Finasteride Raw Materials by Headspace Capillary Gas Chromatography

January 2013 in “Zhongguo yaofang”

The method effectively detects residual solvents in finasteride raw materials.

research Synthesis and Pharmacological Evaluation of New 16-Methyl Pregnane Derivatives.

18 citations , January 2002 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

New pregnane derivatives were more effective than finasteride at inhibiting a key enzyme for male pattern baldness.

research Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue

13 citations , March 1999 in “Biochemical Journal”

Overexpressing SSAT in mice makes them highly sensitive to polyamine analogues, causing liver damage and high mortality.

A Randomized, Blinded, Three-Arm, Multicenter Trial Comparing the Efficacy and Safety of Fluconazole Given Once Daily for 3 or 6 Weeks with Griseofulvin Given Once Daily for 6 Weeks in Pediatric Patients with Tinea Capitis

research A randomized, blinded, three-arm, multicenter trial comparing the efficacy and safety of fluconazole given once daily for 3 or 6 weeks with griseofulvin given once daily for 6 weeks in pediatric patients with tinea capitis

March 2005 in “Journal of The American Academy of Dermatology”

The two lotions used day and night may be a good alternative to minoxidil for hair loss treatment with better cosmetic effects and tolerance.

research Evaluation of the effect of formic acid and sodium formate on hair reduction in rat

3 citations , June 2011 in “Clinical Cosmetic and Investigational Dermatology”

research Development of Minoxidil-Loaded Calcium Citrate Nanoparticles

January 2026 in “New Journal of Chemistry”

Minoxidil-loaded nanoparticles improve hair loss treatment by enhancing delivery and reducing irritation.

Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Antioxidant enzyme expression of mRNA and protein in the epididymis of finasteride-treated male rat offspring during postnatal development

2 citations , September 2017 in “Archives of Medical Science”

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

research Lysocellin, a metabolite of the novel drug ‘alopestatin’, induces G1 arrest and prevents cytotoxicity induced by etoposide

1 citations , April 2006 in “International Journal of Oncology”

Lysocellin helps stop cell damage from etoposide and may prevent hair loss.

research Efeitos da doxazosina e da combinação doxasina mais finasterida sobre a interação parenquina-estroma na prostata de rato

January 2008

The combined treatment of Finasteride and Doxazosin affects prostate tissue by reducing cell growth and altering hormone levels.

Analysis of Finasteride Treatment and Its Withdrawal in Rat Hypothalamus and Hippocampus at Whole-Transcriptome Level

research Analysis of the finasteride treatment and its withdrawal in the rat hypothalamus and hippocampus at whole-transcriptome level

March 2024 in “Journal of Endocrinological Investigation”

Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.