45 citations
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July 2025 in “Journal of Medicinal Chemistry” The document discusses the submission of a New Drug Application (NDA) to the U.S. FDA for vepdegestrant (ARV-471), a PROTAC protein degrader targeting the estrogen receptor, by Arvinas and Pfizer. This submission is based on positive results from the Phase 3 VERITAC-2 trial and marks a significant milestone as vepdegestrant is anticipated to be the first FDA-approved PROTAC degrader. PROTACs, a novel class of molecules, selectively degrade disease-causing proteins and offer advantages over traditional small molecule inhibitors, such as mitigating off-target effects and overcoming drug resistance. Despite concerns about their large molecular weight and drug-like properties, recent clinical results have been promising. The success of PROTACs has inspired the development of other chimeric molecules for therapeutic applications.
1 citations
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January 2019 in “Clinical, Cosmetic and Investigational Dermatology” Jarilla-Coffea extract gel effectively and safely increases eyelash and eyebrow thickness in women.
October 2019 in “DOAJ (DOAJ: Directory of Open Access Journals)” Menopausal acne is mainly caused by hormonal changes and can be managed with topical treatments, lifestyle changes, and sometimes medication.
January 2022 in “International Journal of Pharmacognosy and Pharmaceutical Sciences” Semecarpus anacardium Linn. has multiple medicinal benefits, including anti-inflammatory and antioxidant effects.
49 citations
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February 2014 in “Clinical Cosmetic and Investigational Dermatology” Furunculosis is a recurring skin infection needing careful hygiene and treatment to manage and prevent spread.
February 2026 in “Dove Medical Press (Taylor and Francis Group)” Upadacitinib can effectively regrow hair in alopecia areata patients without worsening sarcoidosis.
May 2026 in “Dove Medical Press (Taylor and Francis Group)” Buffy coat PRP is more effective for hair growth in androgenetic alopecia than apheresis PRP.
21 citations
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February 2015 in “Clinical Cosmetic and Investigational Dermatology” Keloids may be influenced by stress and psychological factors.
184 citations
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January 2000 in “European Urology” Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.
1 citations
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February 2021 in “Gastroenterology” A woman with inflammatory bowel disease improved after treatment with ustekinumab for a rare skin condition associated with her disease.
1 citations
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July 2012 in “EFSA journal” KF2BL20 does not have proven benefits for maintaining normal hair.
30 citations
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January 2023 in “EFSA journal” Adults should not consume more than 255 micrograms of selenium per day to avoid risk of hair loss and other side effects.
18 citations
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October 2013 in “EFSA Journal” Coriander seed oil is safe for healthy adults at up to 600 mg per day.
1 citations
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July 2012 in “EFSA Journal” The combination of certain vitamins and pumpkin seed oil has not been proven to maintain normal hair.
July 2012 in “EFSA supporting publications” The EFSA maintained its view that spermidine's effect on hair growth is related to disease treatment and does not meet the health claim criteria.
1 citations
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February 2024 in “International Journal of Physics Research and Applications” Powdered milk in Senegal has varying heavy metal levels, with some exceeding safety limits, needing more regulation.
September 2024 in “American Journal of Modern Physics” Calcium and Potassium levels in some Senegalese powdered milk samples exceed safe limits, posing health risks.
3 citations
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June 2011 in “EFSA Journal” Spermidine's effect on hair growth is not proven.
4 citations
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September 2012 in “Clinical Pharmacology in Drug Development” Different drug doses approved in Japan and the U.S. are not mainly due to different clinical responses, and ethnic factors should be considered in setting drug doses.
July 2007 in “Journal of Generic Medicines” The UK High Court revoked Lundbeck's patent for Escitalopram, and second medical use claims based on dosage were not considered novel.
84 citations
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August 2023 in “Drugs” Ritlecitinib is approved in the USA and Japan for treating severe hair loss in people aged 12 and older.
59 citations
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October 2020 in “Stem Cell Reviews and Reports” Men have higher COVID-19 mortality rates than women due to biological and lifestyle factors.
28 citations
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January 1989 in “Toxicologic Pathology” Minoxidil may cause heart changes; use caution and monitor patients with heart conditions.
3 citations
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December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” PRP improves short-term pain and function in shoulder injuries, but long-term benefits are unclear.
March 2026 in “Korean Journal of Clinical Pharmacy” In 2024, the FDA approved 50 new drugs, including treatments for hair loss, anemia, high blood pressure, and Alzheimer's.
October 2025 in “Progress In Microbes & Molecular Biology” PCOS is linked to gut bacteria changes, suggesting gut-focused treatments might help.
January 2022 in “Kafkas Universitesi Veteriner Fakultesi Dergisi” The research improved understanding of twin births and fertility in Tibetan sheep, helping animal farming.
March 2012 in “EFSA Journal” Iron intake has not been proven to maintain normal hair growth.
324 citations
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July 2020 in “Applied Water Science” Water near Abakaliki mines has high toxic metal levels, posing health risks.
282 citations
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October 2006 in “The Journal of Clinical Endocrinology and Metabolism” The Endocrine Society advised against routine testosterone therapy for women, citing a need for more research on long-term safety and a clear definition of androgen deficiency.