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GlossaryNerve Fibers

long extensions of neurons transmitting electrical impulses

Nerve fibers, also known as nerve filaments or neural fibers, are the long, thread-like extensions of nerve cells (neurons) that transmit electrical impulses throughout the body. These fibers are essential for communication within the nervous system, enabling sensations, movements, and various bodily functions by carrying signals between the brain, spinal cord, and other parts of the body.

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research A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle - dependent changes in mast cell - nerve fiber contacts in murine skin

109 citations , April 1997 in “Archives of Dermatological Research”

Mast cell and nerve fiber interactions in mouse skin change with the hair cycle.

research Fibre optic confocal imaging (FOCI) of keratinocytes, blood vessels and nerves in hairless mouse skin in vivo

36 citations , February 1998 in “Journal of Anatomy”

Fibre optic confocal imaging can visualize skin layers, blood vessels, and nerves in live mice.

research Changes in intraepidermal nerve fiber and Langerhans cell densities in the plantar skin of rats after mercuric chloride exposure

6 citations , November 2017 in “Journal of the Peripheral Nervous System”

Mercury exposure damages small nerve fibers in rats' skin.

research 509 Using the human iPSCs-derived sensory neurons re-innervated skin ex vivo model to investigate mast cell-nerve fiber cross-talk in solar elastosis

November 2024 in “Journal of Investigative Dermatology”

Nerve fibers may worsen mast cell activity, leading to abnormal elastic fiber buildup from sun exposure.

research Characteristic intraepidermal nerve fibre endings of the intervibrissal fur in the mystacial pad of the rat: morphological details revealed by intravital methylene blue staining and the zinc iodide-osmium tetroxide technique

5 citations , July 1999 in “Journal of Anatomy”

Methylene blue staining effectively highlights detailed nerve structures in rat fur.

research Characteristic intraepidermal nerve fibre endings of the intervibrissal fur in the mystacial pad of the rat: morphological details revealed by intravital methylene blue staining and the zinc iodide‐osmium tetroxide technique

5 citations , July 1999 in “Journal of Anatomy”

Methylene blue staining effectively reveals detailed nerve structures in rat snouts.

research Effects of ultraviolet radiation on human cutaneous nerve fibres

9 citations , June 2009 in “Cell Proliferation”

Cream 1 protects skin nerve endings from UV damage.

research Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice

1 citations , September 2025 in “Physiologia”

Ovalbumin–aluminum sensitization causes increased pain sensitivity and nerve changes in mice.

research A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata

4 citations , July 2024 in “Pharmacology Research & Perspectives”

Ritlecitinib is safe and may effectively treat alopecia areata.

research Growth of Nerve Fibers to Merkel Cells Observed in Co-Culture of Sensory Ganglia and Sinus Hair Follicles

1 citations , January 2003

Merkel cells likely attract sensory nerve fibers.

research Three-dimensional analysis of intraepidermal nerve fibres and Langerhans cells in keloids with a focus on pruritus

August 2025 in “Scientific Reports”

Itchy keloids on the chest are linked to more nerve fibers and substance P.

research Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

84 citations , June 2013 in “Stem Cells Translational Medicine”

New methods for skin and nerve regeneration can improve healing and feeling after burns.

research Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin

28 citations , March 2011 in “Journal of Investigative Dermatology”

Hair follicles help guide nerve growth, improving touch recovery in skin grafts.

research Tissue‐engineering approaches to enhance nerve regeneration during wound healing

March 2006 in “The FASEB Journal”

Two methods improved nerve regeneration and touch recovery in skin grafts for burn patients.

research Research progress on the role of peripheral nerves in wound healing

September 2025 in “Journal of Zhejiang University (Medical Sciences)”

Peripheral nerves are essential for skin wound healing and future treatments could improve by focusing on nerve and blood vessel regeneration.

research Role of collagen VI in peripheral nerves and wound-induced hair regrowth

January 2015

Collagen VI is crucial for nerve function and affects wound-induced hair regrowth.

research Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects

January 2005 in “Zhonghua chuangshang guke zazhi”

Human hair keratin is a promising material for nerve repair.

research Exosomes from Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts to Bridge Rat Facial Nerve Defects

December 2022 in “Stem Cells and Development”

Exosomes from stem cells help improve nerve repair in rats.

research Arrangement of elastic fibres in the integument of domesticated mammals.

12 citations , January 1994 in “PubMed”

Elastic fiber arrangement in mammal skin varies by hair density and body region.

research Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects

May 2005 in “Zhonghua chuangshang guke zazhi”

Human hair keratin can help nerve regeneration and is a promising material for nerve repair.

research MP45-12 CHRONIC ADMINISTRATION OF A LIMK2 INHIBITOR IMPROVES CAVERNOSAL VENO-OCCLUSIVE DYSFUNCTION THROUGH SUPPRESSION OF CAVERNOSAL FIBROSIS IN A RAT MODEL OF ERECTILE DYSFUNCTION AFTER CAVERNOSAL NERVE INJURY

April 2017 in “The Journal of urology/The journal of urology”

Long-term use of certain prostate drugs can worsen erectile dysfunction by changing penile tissue, especially in rats with high blood pressure.

research Neural Mechanisms of Hair Growth Control

101 citations , January 1997 in “Journal of Investigative Dermatology Symposium Proceedings”

Nerves and chemicals in the body can affect hair growth and loss.

research Sensitive skin

94 citations , January 2016 in “Journal of the European Academy of Dermatology and Venereology”

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

research TRPV3 as a Therapeutic Target for Itch

88 citations , April 2012 in “Journal of Investigative Dermatology”

Blocking TRPV3 may help treat itch in dry skin conditions.

research Developmental timing of hair follicle and dorsal skin innervation in mice

86 citations , May 2002 in “Journal of comparative neurology”

Nerve growth in mouse skin and hair follicles happens in stages and is closely linked to hair development.

Adaptations in the Structure and Innervation of Follicle-Sinus Complexes to an Aquatic Environment as Seen in the Florida Manatee (Trichechus Manatus Latirostris)

research Adaptations in the structure and innervation of follicle‐sinus complexes to an aquatic environment as seen in the Florida manatee (Trichechus manatus latirostris)

46 citations , July 2007 in “Journal of comparative neurology”

Manatee whiskers are specially adapted for touch in water.

Localization of Varicella-Zoster Virus Nucleic Acids and Proteins in Human Skin

research Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats

3 citations , August 2018 in “Deleted Journal”

Guasha changed rat skin appearance and blood vessels temporarily without affecting certain nerve proteins or fiber structure.

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Related Terms

Research

research A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle - dependent changes in mast cell - nerve fiber contacts in murine skin

research Fibre optic confocal imaging (FOCI) of keratinocytes, blood vessels and nerves in hairless mouse skin in vivo

research Changes in intraepidermal nerve fiber and Langerhans cell densities in the plantar skin of rats after mercuric chloride exposure

research 509 Using the human iPSCs-derived sensory neurons re-innervated skin ex vivo model to investigate mast cell-nerve fiber cross-talk in solar elastosis

research Characteristic intraepidermal nerve fibre endings of the intervibrissal fur in the mystacial pad of the rat: morphological details revealed by intravital methylene blue staining and the zinc iodide-osmium tetroxide technique

research Characteristic intraepidermal nerve fibre endings of the intervibrissal fur in the mystacial pad of the rat: morphological details revealed by intravital methylene blue staining and the zinc iodide‐osmium tetroxide technique

research Effects of ultraviolet radiation on human cutaneous nerve fibres

research Combined Systemic and Cutaneous Ovalbumin–Aluminum Sensitization Triggers Thermal Hyperalgesia, Spinal Gliosis, and Nociceptive Nerve Fibers Sprouting in Mice

research A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata

research Growth of Nerve Fibers to Merkel Cells Observed in Co-Culture of Sensory Ganglia and Sinus Hair Follicles

research Three-dimensional analysis of intraepidermal nerve fibres and Langerhans cells in keloids with a focus on pruritus

research Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment

research Hair Follicles Guide Nerve Migration In Vitro and In Vivo in Tissue-Engineered Skin

research Tissue‐engineering approaches to enhance nerve regeneration during wound healing

research Research progress on the role of peripheral nerves in wound healing

research Role of collagen VI in peripheral nerves and wound-induced hair regrowth

research Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects

research Exosomes from Hair Follicle Epidermal Neural Crest Stem Cells Promote Acellular Nerve Allografts to Bridge Rat Facial Nerve Defects

research Arrangement of elastic fibres in the integument of domesticated mammals.

research Experimental study on the compatibility and degradation of human hair keratin bridging for peripheral nerve defects

research MP45-12 CHRONIC ADMINISTRATION OF A LIMK2 INHIBITOR IMPROVES CAVERNOSAL VENO-OCCLUSIVE DYSFUNCTION THROUGH SUPPRESSION OF CAVERNOSAL FIBROSIS IN A RAT MODEL OF ERECTILE DYSFUNCTION AFTER CAVERNOSAL NERVE INJURY

research Neural Mechanisms of Hair Growth Control

research Sensitive skin

research TRPV3 as a Therapeutic Target for Itch

research Developmental timing of hair follicle and dorsal skin innervation in mice

research Adaptations in the structure and innervation of follicle‐sinus complexes to an aquatic environment as seen in the Florida manatee (Trichechus manatus latirostris)

research Localization of varicella-zoster virus nucleic acids and proteins in human skin

research Sensory Reinnervation of Human Skin by Human Neural Stem Cell‒Derived Peripheral Neurons Ex Vivo

research The Pathological Culprit of Neuropathic Skin Pain in Long COVID-19 Patients: A Case Series

research Effects of Guasha on histomorphology of scraped skins and on expression of calcitonin gene-related peptide and substance P in rats