November 2020 in “Elsevier eBooks” Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.
24 citations
,
July 2018 in “Drug Design Development and Therapy” NTF gel improves finasteride delivery for hair loss treatment, reducing side effects.
18 citations
,
March 2019 in “Journal of The European Academy of Dermatology and Venereology” Finasteride use doesn't cause sexual dysfunction in men with hair loss.
5 citations
,
November 2020 in “JAMA Dermatology” Finasteride may cause side effects; more research needed.
29 citations
,
September 2014 in “Current Opinion in Endocrinology, Diabetes and Obesity” Finasteride and dutasteride effectively treat hair loss in men and women, but may cause side effects like low libido and depression.
January 2026 in “Frontiers in Cellular Neuroscience” Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.
9 citations
,
January 2009 in “PubMed” Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
40 citations
,
April 2018 in “Endocrine” PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.
9 citations
,
January 2018 in “American Journal of Men's Health” Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.
37 citations
,
September 2018 in “Psychoneuroendocrinology” Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
11 citations
,
November 2021 in “International journal of molecular sciences” Gut microbes significantly affect brain steroid levels.
5 citations
,
April 2024 in “ACS Chemical Neuroscience” A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.
17 citations
,
May 2008 in “Pharmacopsychiatry” Finasteride improved symptoms in a schizophrenia patient.
403 citations
,
November 2005 in “Journal of Endocrinology” Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.
134 citations
,
February 2005 in “Neuropsychopharmacology” GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.
31 citations
,
January 2017 in “Advances in Experimental Medicine and Biology” Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.
24 citations
,
June 2013 in “Journal of neuroendocrinology” Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
9 citations
,
December 2021 in “Androgens” Androgens like testosterone may help treat traumatic brain injury by reducing mitochondrial stress and inflammation.
January 2026 in “Neurochemistry International” 24-Hydroxycholesterol reduces DHT formation in brain cancer cells, linking cholesterol and hormone metabolism.
January 2025 in “Anais Brasileiros de Dermatologia” Male pattern baldness worsens with age and can be treated with medications like minoxidil and finasteride, but side effects and personalized care are important.
Early NAS level changes affect alcohol consumption vulnerability.
4 citations
,
January 2018 in “General Physiology and Biophysics” The steroids allopregnanolone and allotetrahydrodeoxycorticosteron worsened absence seizures in rats.
223 citations
,
December 2010 in “The Journal of Sexual Medicine” Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.
36 citations
,
June 2014 in “PLOS ONE” Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.
35 citations
,
April 2013 in “Sexual medicine reviews” 5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
15 citations
,
March 2020 in “Anais Brasileiros De Dermatologia” Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.
15 citations
,
May 2004 in “Facial Plastic Surgery Clinics of North America” Treat pattern hair loss with finasteride and topical minoxidil.
10 citations
,
August 2020 in “International Journal of Andrology” 5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.
8 citations
,
March 2020 in “Metabolites” Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.
5 citations
,
May 2018 in “Therapeutic advances in drug safety” Androgen use may increase the risk of stroke, but more research is needed.