research Signaling pathways in the mechanisms of drug action
Signaling pathways are key targets for developing effective drugs.
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research Harnessing neuroendocrine controls of keratin expression: A new therapeutic strategy for skin diseases?
Using neurohormones to control keratin can lead to new skin disease treatments.
research Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone
In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.
research Glycol Ethers and Neurodevelopment: Investigating the Impact of Prenatal Exposures
Exposure to certain glycol ethers during pregnancy may be linked to lower verbal comprehension in children.
research Social isolation‐induced increase in α4and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAAreceptor function
Social isolation makes rats more sensitive to alcohol's effects on the brain.
research MicroRNA-Enriched Exosomes from Different Sources of Mesenchymal Stem Cells Can Differentially Modulate Functions of Immune Cells and Neurogenesis
Exosomes from different stem cell sources affect immune cells and brain cell growth differently.
research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice
Finasteride reduces new brain cells in male mice, possibly causing depression.
research Sex Hormones and their Analogues in Neuroimmune Biology
Sex hormones influence immune responses and may help treat diseases.
research Finasteride inhibits epinephrine synthesis in humans: implication for sexual dysfunction
Finasteride may cause sexual dysfunction by reducing epinephrine levels.
research Molecular docking simulation studies on potent butyrylcholinesterase inhibitors obtained from microbial transformation of dihydrotestosterone
Metabolite 7 is a strong inhibitor for Alzheimer's disease management.
research Effect of neurosteroid dehydroepiandrosterone on the higher nervous activity of old non-human primates
DHEA improved brain function and behavior in old monkeys and had additional health benefits.
research Mixture effects of endocrine disrupting compounds in vitro
Weak endocrine disruptors in mixtures can have significant effects and should be considered in risk assessments.
research Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: Potential role of endogenous neurosteroids?
Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.
research Midazolam Ameliorates the Behavior Deficits of a Rat Posttraumatic Stress Disorder Model through Dual 18 kDa Translocator Protein and Central Benzodiazepine Receptor and Neurosteroidogenesis
Midazolam reduces PTSD-like behavior in rats by acting on specific brain receptors.
research Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep
Reducing neurosteroid levels worsens brain injury in fetal sheep.
research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain
Androgens can affect glucocorticoid signaling in specific mouse brain areas.
research Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep
Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.
research Progesterone-induced spike-wave discharges are inhibited by finasteride
Finasteride blocks progesterone's effect on brain activity linked to epilepsy.
research A neuroendocrinological perspective on human hair follicle pigmentation
Brain hormones significantly affect hair color and could potentially be used to prevent or reverse grey hair.
research Hormone-dependent medial preoptic/lumbar spinal cord/autonomic coordination supporting male sexual behaviors
Testosterone and its byproducts help support male sexual behavior through different pathways in the brain and body.
research Effective holistic characterization of small molecule effects using heterogeneous biological networks
Integrating biological networks improves drug repurposing and ADR prediction.
research Allopregnanolone Alters the Gene Expression Profile of Human Glioblastoma Cells
Allopregnanolone changes gene expression in glioblastoma cells.
research 1. 2年間の低負荷レジスタンストレーニングが高齢者の筋機能に及ぼす効果(第134回日本体力医学会関東地方会)
Blocking 5α-reductase can reduce sleep deprivation-related behavioral issues in rats.
research Nocebo effect in Dermatology
Negative expectations can cause adverse effects in dermatology treatments, like with finasteride for baldness, and careful communication can help reduce these nocebo responses.
research How Does Altered Metabolism Lead to Seizure Control? Partially Filling the Knowledge Gap
Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats
Allopregnanolone affects fear responses differently in male and female rats, possibly explaining sex differences in anxiety disorders.
research Finasteride promotes worsening of the cardiac deleterious effects of nandrolone decanoate and protects against genotoxic and cytotoxic damage
Finasteride worsens heart damage but reduces cell toxicity caused by nandrolone decanoate.
research Small Molecule Treatments Improve Differentiation Potential of Human Amniotic Fluid Stem Cells
Small molecule treatments improve the ability of human amniotic fluid stem cells to become different cell types.
research Oral intake of anti-hangover substance increases aldehyde dehydrogenase activity: New preventive and therapeutic potentials for oxidative neuronal injury?
The anti-hangover product may boost enzyme activity to help prevent brain damage.