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Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

Most women with depression in the study had low vitamin D levels.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

DHEA improved brain function and behavior in old monkeys and had additional health benefits.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Altered metabolism can help control seizures by changing brain signaling and energy use, suggesting new treatments for epilepsy.

Finasteride reduces new brain cells in male mice, possibly causing depression.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Stress increases neurosteroids that help prevent seizures.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

The protein StAR is found in 17 different organs and can affect hair loss and brain functions, but its full role is not yet fully understood.

Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.

Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Finasteride and dutasteride may cause depression and anxiety, especially in younger men.

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

Menopause and aging can affect women's quality of life and sexuality, but hormone therapies may help alleviate these issues.

A brain-produced steroid causes increased scratching in mice with a skin condition similar to eczema.