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3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Ovarian and stress hormones can change GABA A receptors through neurosteroids.

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

Stress increases neurosteroids that help prevent seizures.

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

Stress increases neurosteroids that help prevent seizures.

5α-reduced neurosteroids may help regulate glial cell differentiation.

EETs can delay seizures by affecting GABA activity, offering potential new treatments for seizures.

Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.

Letrozole reduces seizures but not brain damage in mice.

Mild exercise reduces pain in older rats through a brain chemical, while intense exercise reduces pain in all rats through a different pain-blocking process.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Neurosteroids show promise for treating epilepsy and more research is needed.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

A natural steroid in the body may protect against eye damage in glaucoma.

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

Ketogenic diet, neurosteroids, and HMGB1-TLR4 signaling pathway are potential targets for new epilepsy treatments.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

DHEA improved brain function and behavior in old monkeys and had additional health benefits.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.

Reduced neurosteroids and growth issues can harm fetal brain development, especially in males.