Search

for
Search:

A new compound was created in 2010 that can control oil production when applied to the skin, and its effects are completely reversible after two weeks.

research An overview on 5α-reductase inhibitors

219 citations , October 2009 in “Steroids”

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

research Experimental Evaluation of 3-meta-Pyridine-1,2,4-Oxadiazole Derivative of Deoxycholic Acid as a Prototype of 5-α-Reductase Inhibitors in In Silico and In Vivo Models

1 citations , February 2023 in “Russian Journal of Bioorganic Chemistry”

The new compound may be a safer alternative to finasteride for prostate protection.

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations , October 2009 in “Journal of Investigative Dermatology”

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

research Silencing the androgen receptor: New skills for antiandrogen oligonucleotide skin and hair therapy

8 citations , February 2009 in “Journal of Dermatological Science”

Targeting androgen receptors with antiandrogen oligonucleotides could effectively treat hair loss.

research Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study

3 citations , January 2022 in “Precision medicine and clinical omics”

Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

research Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing

November 2025 in “Drug Testing and Analysis”

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations , January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

25 Years of Estrogen Receptor Beta: A Personal Journey

research 25 years of ERβ: a personal journey

11 citations , September 2021 in “Journal of molecular endocrinology”

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

research Non-competitive androgen receptor inhibition in vitro and in vivo

January 2010 in “Yearbook of Endocrinology”

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

In Silico Investigation of Possible Multi-Target Drugs Against Glutamate S-Transferase and Prolyl tRNA Synthetase in Onchocerca Volvulus

research In silico investigation of possible multi-target drugs against Glutamate S-transferase and prolyl tRNA synthetase in Onchocerca volvulus

June 2026 in “Open Access Research Journal of Biology and Pharmacy”

Bedaquiline, Telmisartan, Diosmin, Azelastine, and Adapalene may be effective treatments for onchocerciasis.

research The influence of selected steroid hormones on the physicochemical behaviour of DPPC liposomes

65 citations , April 2007 in “Chemistry and Physics of Lipids”

Steroid hormones change the size, charge, and stability of DPPC liposomes.

research The manipulation of the cedrol metabolism pathway by baricitinib and its immune interaction mechanism against chemotherapy-induced alopecia

May 2026 in “Bioorganic Chemistry”

A Microscopy-Based Small Molecule Screen in Primary Neurons Reveals Neuroprotective Properties of the FDA-Approved Anti-Viral Drug Elvitegravir

research A microscopy-based small molecule screen in primary neurons reveals neuroprotective properties of the FDA-approved anti-viral drug Elvitegravir

3 citations , September 2020 in “Molecular Brain”

The anti-viral drug Elvitegravir may protect brain cells from damage related to neurodegenerative diseases.

research The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial

4 citations , August 2024 in “PLoS ONE”

Both injectable contraceptives lower testosterone and SHBG levels, with NET-EN having a greater effect than DMPA-IM.

research 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

54 citations , May 2015 in “Endocrinology”

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

Developing New Dual-Action Antiviral/Anti-Inflammatory Small Molecules for COVID-19 Treatment Using In Silico and In Vitro Approaches

research DEVELOPING NEW DUAL-ACTION ANTIVIRAL/ANTI-INFLAMMATORY SMALL MOLECULES FOR COVID-19 TREATMENT USING IN SILICO AND IN-VITRO APPROACHES

November 2024

Hit15 shows promise as a COVID-19 treatment by reducing virus infection and inflammation.

research Sex Hormones and their Analogues in Neuroimmune Biology

9 citations , September 2010 in “Immunology Endocrine & Metabolic Agents - Medicinal Chemistry”

Sex hormones influence immune responses and may help treat diseases.

← Previous page Next page →