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5 alpha-reductase inhibitors can slightly improve symptoms of enlarged prostate but have a high risk of sexual side effects.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

Finasteride blocks progesterone's effect on absence seizures in rats.

DHEA improved brain function and behavior in old monkeys and had additional health benefits.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.

Finasteride treats hair loss but may cause low libido, erectile issues, and depression.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Some common medications can harm male fertility, but many effects can be reversed.

Some hormone-related drugs may protect brain cells in Parkinson's disease differently in men and women.

Testosterone significantly affects sexual desire in both men and women, but its impact on women is more complex and influenced by psychological factors.

Paeoniflorin protects brain cells by involving a specific protein and neurosteroids.

Pregnancy increases certain GABA_A receptors in rat brains, influenced by steroid levels.

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

Personalized treatment with inhibitors, minoxidil, and laser therapy helps hair loss.

Dihydrotestosterone increases growth and spread of human brain cancer cells, and blocking its formation might help treat this cancer.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Consider benefits and risks of new alopecia treatments for safety.

Changing Allopregnanolone levels in newborns affects adult behavior and anxiety.

Early neurosteroid changes can alter adult brain function and behavior.

Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.

Neurosteroids affect prolactin levels in sheep differently depending on stress and pregnancy conditions.