research Finasteride treatment and neuroactive steroid formation.
Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.
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180-210 / 1000+ results research Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices
Progesterone protects neurons from damage by converting to allopregnanolone, which works through GABAA receptors.
research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity
research Interaction of chronic ethanol exposure and finasteride: sex and strain differences
Finasteride reduces alcohol withdrawal effects, especially in female mice.
research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men
Finasteride can cause sexual problems and depression in young men.
research 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis
Some hair loss and prostate drugs might increase the risk of diabetes and heart disease.
research TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice
Etifoxine, an anxiety drug, can lessen brain inflammation and cognitive issues in mice, partly by increasing production of protective brain steroids.
research The Influence of Finasteride on Mean and Relative Spectral Density of EEG Bands in Rat Model of Thioacetamide-Induced Hepatic Encephalopathy
Finasteride may protect brain and improve behavior in rats with liver failure.
research Efectos de la alteración de los niveles de allopregnanolona durante periodos críticos del neurodesarrollo en la vulnerabilidad al consumo de alcohol
Early NAS level changes affect alcohol consumption vulnerability.
research 5α-Reductases In Human Physiology: an Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
research Simultaneous Determination of Selected Steroids with Neuroactive Effects in Human Serum by Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry
A new method accurately measures nine neuroactive steroids in small blood samples, helping to study brain diseases.
research Allopregnanolone, the active metabolite of progesterone protects against neuronal damage in picrotoxin-induced seizure model in mice
research The gut‐microbiota‐brain axis: Focus on gut steroids
Gut bacteria affect steroid levels, influencing health conditions and potential treatments.
research Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?
Finasteride may cause long-lasting sexual side effects.
research 2-Substituted 4-(Thio)chromenone 6-O-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase
New compounds were made that block an enzyme linked to breast cancer better than existing treatments.
research Progesterone enhances ethanol-induced modulation of mesocortical dopamine neurons: antagonism by finasteride
Progesterone boosts alcohol's effect on brain, finasteride counters it.
research Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep
Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.
research Finasteride Attenuates Pathological Gambling in Patients With Parkinson Disease
Finasteride reduces gambling symptoms in Parkinson's patients.
research Safety concerns regarding 5α reductase inhibitors for the treatment of androgenetic alopecia
5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.
research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride
Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.
research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.
research Finasteride for androgenetic alopecia is not associated with sexual dysfunction: a survey‐based, single‐centre, controlled study
Finasteride use doesn't cause sexual dysfunction in men with hair loss.
research Finasteride improves motor, EEG, and cellular changes in rat brain in thioacetamide-induced hepatic encephalopathy
Finasteride helps brain function in rats with liver-related brain issues.
research Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats
research TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model
Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
research Isoallopregnanolone reduces tic‐like behaviours in the D1 CT ‐7 mouse model of Tourette syndrome
Isoallopregnanolone may be a safe and effective treatment for reducing tics in a mouse model of Tourette syndrome.
research The 5-alpha reductase inhibitor finasteride reduces dyskinesia in a rat model of Parkinson’s disease
Finasteride reduces movement issues in Parkinson's disease rats.
research Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens
Finasteride affects brain processes related to neurotransmission and metabolism, potentially helping with neuropsychiatric conditions.
research Finasteride Has Regionally Different Effects on Brain Oxidative Stress and Acetylcholinesterase Activity in Acute Thioacetamide-Induced Hepatic Encephalopathy in Rats
Finasteride affects brain stress and enzyme activity differently in various regions, possibly helping with liver-related brain issues.
research Anti-nociceptive and anti-inflammatory properties of 5alpha-reductase inhibitor finasteride in experimental animals
Finasteride helps reduce pain and inflammation in animals.