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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.

Neurosteroids help balance brain signals when certain inhibitions are reduced.

New genes and pathways are important for testosterone production and male sexual development.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

Neonatal neurosteroid levels affect adult brain function and behavior.

Reduced neurosteroids and growth issues can harm fetal brain development, especially in males.

Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.

Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.

Progesterone and its byproducts control a specific receptor in the brain independently of progesterone receptors, affecting conditions related to the menstrual cycle.

A natural steroid in the body may protect against eye damage in glaucoma.

Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

Male tissue has more cell death than female tissue after ischemia, and some neurosteroids only protect female cells.

Neurosteroids show promise for treating epilepsy and more research is needed.

Stress increases neurosteroids that help prevent seizures.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Sex and stress steroids quickly change brain cell structures in the hippocampus.

Early neurosteroid changes can alter adult brain function and behavior.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.

The methods accurately measured brain androgens, showing most 5α-androstane-3α,17β-diol comes from outside the brain, while androsterone is both transported and made in the brain.

5α-reduced neurosteroids may help regulate glial cell differentiation.

Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.

Neurosteroids play a key role in controlling the brain-adrenal gland activity in pregnant sheep, both in normal and stressful situations.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Neurosteroid production in the brain may delay seizure onset.

Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.

Anabolic steroids and inflammation can disrupt androgen metabolism, potentially causing health issues.

Changing Allopregnanolone levels in newborns affects adult behavior and anxiety.