research Folate receptor β performs an immune checkpoint function in activated macrophages
Folate receptor β helps suppress the immune system in macrophages and affects cancer growth and hair health.
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570-600 / 1000+ resultsresearch Over-, ectopic-expression of FoxN1 at early life adversely influences lymphopoiesis (HEM3P.280)
Early over-expression of FoxN1 harms immune and skin development.
research The nude gene and the skin
The nude gene is important for skin and hair development.
research Frontal Fibrosing Alopecia in Men: A Review of the Literature
Frontal fibrosing alopecia in men is often misdiagnosed and needs better diagnostic criteria and treatment strategies.
research Updated diagnostic criteria for frontal fibrosing alopecia
New criteria for diagnosing frontal fibrosing alopecia include specific scalp and eyebrow hair loss as major factors and other hair loss areas and hair analysis as minor factors.
research Post-marketing safety signals of four JAK inhibitors for alopecia areata: an indication-restricted FAERS pharmacovigilance study
This study analyzed the post-marketing safety profiles of four JAK inhibitors— tofacitinib, baricitinib, ruxolitinib, and ritlecitinib—used for alopecia areata by examining data from the FDA Adverse Event Reporting System from 2015 to 2025. The results showed that each JAK inhibitor had distinct safety signals: tofacitinib was linked to neuropsychiatric and autoimmune events, baricitinib to thrombocytosis, deep vein thrombosis, and breast cancer, ruxolitinib to pyrexia and elevated blood cholesterol, and ritlecitinib to gastrointestinal events and creatine phosphokinase elevation. The time-to-onset of adverse events varied, with tofacitinib and ruxolitinib showing earlier onset, ritlecitinib clustering within the first month, and baricitinib having a delayed onset. Serious adverse events were mostly related to infections, but varied by agent. The study concludes that JAK inhibitors for alopecia areata have diverse safety profiles, suggesting the need for agent-specific monitoring and personalized risk assessment in clinical settings.
research Severe scarring alopecia associated with combinational use of ficlatuzumab and gefitinib: a clinical and immunohistochemistry study
Combining ficlatuzumab and gefitinib can cause severe scarring hair loss.
research Ferrous Ferric Chloride Stimulates the Skin Cell Function and Hair Growth in Mice
Ferrous Ferric Chloride may improve skin cell function and increase hair growth in mice.
research Frontal fibrosing alopecia: An update on the hypothesis of pathogenesis and treatment
The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
research Polysaccharide, Conjugate, and mRNA-based Vaccines are Immunogenic in Patients with Netherton Syndrome
Vaccines work well in Netherton syndrome patients, similar to healthy people.
research Frontal Fibrosing Alopecia
Frontal Fibrosing Alopecia is a type of hair loss affecting mostly older women, with no agreed best treatment.
research Focal palmoplantar callosities in non-Herlitz junctional epidermolysis bullosa
Focal palmoplantar callosities may help diagnose non-Herlitz junctional epidermolysis bullosa.
research Lanceolate hair-J (lahJ ): A mouse model for human hair disorders
The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.
research Combined C3b and Factor B Autoantibodies and MPGN Type II
The FDA did not approve certain drugs for prostate cancer prevention due to concerns about their effectiveness and potential risks.
research 42577 Application of the new clinical guidelines in frontal fibrosing alopecia of the male
Current guidelines may overlook beard and sideburn involvement in diagnosing frontal fibrosing alopecia in men.
research 1616 Cross-comparison of inflammatory skin disease transcriptomics identifies PTEN as a pathogenic disease classifier in cutaneous lupus erythematosus
PTEN was identified as a specific marker for the skin disease cutaneous lupus erythematosus, and it helps increase the expression of harmful type I interferons.
research FGF Family: From Drug Development to Clinical Application
FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.
research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice
Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.
research Folliculitis decalvans responsive to tofacitinib: A case series
Tofacitinib may effectively treat folliculitis decalvans.
research Epithelial growth control by neurotrophins: leads and lessons from the hair follicle
Neurotrophins are important for hair growth and could help treat hair loss.
research Exploring the Overlooked Roles and Mechanisms of Fibroblasts in the Foreign Body Response
Fibroblasts play a crucial role in the body's response to implants, needing more research for better treatments.
research 0874 TGF-β signaling-mediated wound healing is required for hair follicle neogenesis
TGF-β signaling is essential for hair follicle regeneration during wound healing.
research 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis
EGFR and MEK inhibitors reduce PD-L1 in hair follicles, possibly causing inflammation.
research 768 Dermal fibroblast expression of lef1 is critical to normal skin and hair development and regenerative wound healing in mice
Lef1 is essential for normal skin, hair growth, and healing wounds in mice.
research Familial frontal fibrosing alopecia: A cross‐sectional study of 20 cases from nine families
Frontal fibrosing alopecia in families shows similar signs to individual cases and may have a genetic link.
research Hair regeneration using microneedle-assisted human basic fibroblast growth factor
Microneedle-assisted therapy with human basic fibroblast growth factor significantly regrew hair in patients with hair loss.
research Cisd2 deficiency impairs neutrophil function by regulating calcium homeostasis via Calnexin and SERCA
Lack of Cisd2 disrupts calcium balance in cells, leading to poorly functioning neutrophils.
research Implications of a Clinically Ignored Site of Acanthosis Nigricans: The Knuckles
Knuckle Acanthosis Nigricans is common in Latin American youth and may indicate early insulin resistance, especially in those with normal weight.
research LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway
PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.
research Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.
Basonuclin helps keratinocytes multiply and prevents them from fully maturing.