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Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat

research Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone.

22 citations , October 2001 in “Biochemical Pharmacology”

GI198745 is more potent and longer-lasting than finasteride, potentially better for treating hair loss.

research EFFECT OF "AMINOPTERIN" ON EPITHELIAL TISSUES

3 citations , June 1983 in “Archives of Dermatology”

Aminopterin effectively improves skin conditions but has toxic side effects that need careful monitoring.

research Chitin Derivative‐Based Detachable Microneedles for Effective Treatment of Androgenic Alopecia

April 2026 in “Advanced Healthcare Materials”

Detachable microneedles with chitin derivatives effectively promote hair regrowth in androgenic alopecia without toxicity.

research Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis

37 citations , January 2016 in “Drug design, development and therapy”

Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research Tribal Colleges and University Project - Native American Internships

January 2015 in “International Journal of Nanomedicine”

Anionic squarticles can effectively counteract amitriptyline overdose, improving survival rates.

research Determination of the efficacy of terbinafine hydrochloride nail solution in the topical treatment of dermatophytosis in a guinea pig model

51 citations , May 2008 in “Mycoses”

Terbinafine HCl nail solutions with DDAIP HCl are more effective than current treatments for nail infections.

research Calcipotriol/dithranol

March 2019 in “Reactions Weekly”

research Enhancing alopecia areata management: Nanocrystal-driven strategy for targeting hair follicles

3 citations , April 2025 in “International Journal of Pharmaceutics”

Nanocrystals improve alopecia areata treatment by better targeting hair follicles.

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