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GlossaryNon-Balding Scalp

area of the head with normal hair growth and no thinning

A non-balding scalp refers to an area of the head where hair growth is normal and there is no significant hair loss or thinning. This term is often used in contrast to areas affected by conditions like androgenetic alopecia, where hair follicles shrink and produce thinner hair, eventually leading to baldness. In a non-balding scalp, hair follicles remain healthy and continue to produce robust hair strands.

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research Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp

124 citations , April 1992 in “Journal of Endocrinology/Journal of endocrinology”

Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

New genes found linked to balding, may help develop future treatments.

research Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian

June 2024 in “Archives of Dermatological Research”

SFRP2 and PTGDS may be key factors in female hair loss.

research Comprehensive transcriptome profiling between balding and non-balding scalp of Female pattern hair loss in Asian

February 2024 in “Research Square (Research Square)”

The research suggests that SFRP2 and PTGDS proteins might be indicators of female pattern hair loss and could contribute to hair loss.

research Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

227 citations , January 1998 in “Journal of Endocrinology”

Cells from balding scalps have more androgen receptors than cells from non-balding scalps.

research Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient

9 citations , January 2017 in “Annals of Dermatology”

The study found genetic differences related to hair development that may explain hair loss in a patient with Trichorhinophalangeal syndrome type I.

A Controlled Study of the Effects of RU58841, a Non-Steroidal Antiandrogen, on Human Hair Production by Balding Scalp Grafts Maintained on Testosterone-Conditioned Nude Mice

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

10 citations , November 1997 in “British Journal of Dermatology”

RU58841 significantly increases hair growth rate and initiates more hair cycles, but doesn't affect hair thickness, suggesting it could be a new treatment for baldness.

research Clinical and instrumental characterization of hair and scalp aging in nonbalding Caucasian women

August 2018 in “Journal of The American Academy of Dermatology”

Aging significantly affects the hair and scalp of nonbalding Caucasian women, with changes that differ from male pattern baldness.

A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

research A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (androgenetic alopecia) scalp

19 citations , March 1996 in “British Journal of Dermatology”

Balding hair follicle cells are smaller, grow less well, and need more effort to culture than non-balding cells.

research A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (androgenetic alopecia) scalp

30 citations , March 1996 in “British Journal of Dermatology”

research A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

9 citations , November 1997 in “British Journal of Dermatology”

research Transplants from balding and hairy androgenetic alopecia scalp regrow hair comparably well on immunodeficient mice

17 citations , May 2003 in “Journal of The American Academy of Dermatology”

Hair from balding and non-balding areas regrows similarly on mice.

research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Hormones and Hair Growth: Variations in Androgen Receptor Content of Dermal papilla Cells Cultured from Human and Red Deer (Cervus Elaphus) Hair Follicles.

34 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human hair growth is influenced by androgen hormones, and red deer mane follicles have similar hormone receptors.

research Message of protease nexin-1 is expressed in human dermal papilla cells and is affected by androgen

March 1998 in “Journal of dermatological science”

Protease Nexin-1 is found in human hair growth cells and is affected by male hormones.

Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

research Establishment of SV40T-transformed human dermal papilla cells and identification of dihydrotestosterone-regulated genes by cDNA microarray

13 citations , June 2007 in “Journal of Dermatological Science”

Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

research Hair, Cutaneous Homeostasis and Stem Cell Functions

January 2014 in “Journal of Investigative Dermatology”

Proteins like aPKC and PDGF-AA, substances like adenosine and ATP, and adipose-derived stem cells all play important roles in hair growth and health, and could potentially be used to treat hair loss and skin conditions.

research Reduced Linear Hair Growth Rates of Vellus and of Terminal Hairs Produced by Human Balding Scalp Grafted onto Nude Mice

23 citations , December 1991 in “Annals of the New York Academy of Sciences”

Balding scalps slow down hair growth.

research The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.

January 2010

Balding hair follicles have reduced growth factors and increased inhibitory factors, suggesting new treatment paths for hair loss.

research Human Scalp Hair Follicles Express Prostaglandin E2 Lipid Mediator and Receptors For Pge2

September 2013

Human scalp hair follicles have PGE2 and its receptors, which might affect hair growth.

research The Metabolism of Dehydroepiandrosterone by Human Scalp Hair Follicles

28 citations , March 1973 in “The Journal of Clinical Endocrinology & Metabolism”

Altered DHEA metabolism in hair follicles may be linked to hair loss in balding men.

research Ultrastructural abnormalities in the dermal papillae of both lesional and clinically normal follicles from alopecia areata scalps

19 citations , August 1996 in “British Journal of Dermatology”

Alopecia areata affects hair follicle structure, even in non-balding areas.

research Androgenetic alopecia is associated with increased scalp hardness

2 citations , January 2020 in “Journal of The European Academy of Dermatology and Venereology”

Balding men have harder scalps.

research SnapshotDx Quiz: August 2016

July 2016 in “Journal of Investigative Dermatology”

Balding scalps show different gene expressions affecting hair growth compared to non-balding scalps.

research Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression

141 citations , November 2007 in “Journal of Investigative Dermatology”

Balding cells age faster due to stress, suggesting stress-targeting treatments for hair loss.

research Epidermal field carcinogenesis in bald-headed: An attempt at finetuning early non-invasive detection

10 citations , April 2009 in “Oncology Reports”

Bald-headed individuals may need early non-invasive detection for skin changes linked to cancer risk.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

Management of the Crown: Addressing Vertex Baldness in Hair Transplantation

research Management of the Crown

2 citations , August 2013 in “Facial Plastic Surgery Clinics of North America”

Treat the front and middle scalp before the vertex in hair transplants, aim for good density, use non-surgical options for young people, and customize treatment for natural results.

Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

research Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia.

January 2016 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

A substance called prostaglandin D2 is found more in bald scalps and it stops hair from growing. Blocking its receptor could potentially treat hair loss.

research Presence of Psoriasis in Areas of Balding in Patients with Both Androgenic Alopecia and Scalp Psoriasis

December 2012

Men with both baldness and scalp psoriasis often don't have psoriasis on bald spots.