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Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid, and Carnitine-Containing Compound in Prostate and Hair Follicle Cell-Based Assays

research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays

3 citations , March 2016 in “Phytotherapy Research”

The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.

research Nuclear and cytosol Androgen Receptor in Androgen Dependent Dermatoses in Female Patients

5 citations , July 2009 in “Experimental and Clinical Endocrinology & Diabetes”

Nuclear AR levels give better insight into hormone effects in skin conditions.

Behavior of the Two Circulating Androgens Testosterone and DHEA and Their Main Intracellular Metabolites in an Androgen-Sensitive Sebocyte Cell Line

research 892 Behavior of the two circulating androgens testosterone and DHEA and their main intracellular metabolites in an androgen-sensitive sebocyte cell line

April 2019 in “Journal of Investigative Dermatology”

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

research [Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)].

June 1980 in “PubMed”

Cyproterone acetate is an effective treatment for women with acne, hair loss, and excessive hair growth.

research Molecular mechanisms of androgen receptor functions

November 2007 in “Data Archiving and Networked Services (DANS)”

Androgen receptors play a key role in male development and prostate cancer, with treatments targeting androgen action.

Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors: Review Article for Pharmacists and Healthcare Professionals

research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals

July 2025 in “Saudi Journal of Medicine and Public Health”

5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.

research Cyclohex-1-ene Carboxylic Acids: Synthesis and Biological Evaluation of Novel Inhibitors of Human 5α Reductase

6 citations , March 2003 in “Archiv Der Pharmazie”

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

research Non-canonical dimerization of the androgen receptor and other nuclear receptors: implications for human disease

25 citations , June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

research Antiandrogen Therapy for Skin and Hair Disease

20 citations , April 2006 in “Dermatologic Clinics”

Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.

research 5α‐Reductase inhibitors and prostatic disease

21 citations , August 1994 in “Clinical endocrinology”

5α-Reductase inhibitors can help treat hair loss, acne, and prostate issues by reducing DHT levels.

research METABOLISM AND ACTION OF ANDROGEN IN THE SKIN

25 citations , November 1979 in “International Journal of Dermatology”

Androgens affect skin conditions like acne and hair loss through specific biochemical pathways.

research Adrenal steroid precursors exert potent androgenic action in the hamster sebaceous glands of flank organs and ears.

8 citations , May 1996 in “Endocrinology”

Certain adrenal hormones can strongly stimulate oil gland growth in hamster skin, similar to male hormones.

research Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

22 citations , January 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

A new method accurately measures nine specific hormones in human blood.

research Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size

15 citations , May 2009 in “Steroids”

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

research 5α-Reductase inhibitors in androgenetic alopecia

January 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”

Natural Product-Inspired Bis(Trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies

August 2025 in “ACS Omega”

New compounds show promise as nonsteroidal treatments for hair loss.

research In Silico Screening of DrugBank Compounds as Potential Inhibitors for Human Steroid 5α-Reductase 2 for Androgen-Related Diseases

December 2023 in “Biointerface Research in Applied Chemistry”

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

research Influence of estrogens on the androgen metabolism in different subunits of human hair follicles.

41 citations , July 2001 in “PubMed”

Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.

research Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics

6 citations , August 2024 in “Steroids”

research [Clinical findings with a low-dosed antiandrogene (cyproteronacetate) and aethinyloestradiol women with virilising symptoms (author's transl)].

3 citations , April 1977 in “PubMed”

The treatment improved acne, seborrhoea, and hirsutism, with some side effects like spotting and nervousness.

research Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist

9 citations , April 2021 in “Expert opinion on pharmacotherapy”

Clascoterone is a new, effective, and safe acne treatment without systemic side effects.

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

research Exploring the Inhibitory Potential of Phytosterols β-Sitosterol, Stigmasterol, and Campesterol on 5-Alpha Reductase Activity in the Human Prostate: An In Vitro and In Silico Approach

12 citations , November 2024 in “Plants”

Phytosterols may help manage prostate issues but are less effective than synthetic drugs.

research [G-proteins, receptor signal transduction, and growth hormone secretion].

March 1993 in “PubMed”

The document concludes that antiandrogenic drugs like cyproterone acetate and spironolactone are effective but not permanent treatments for skin-related androgenization in women.