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Novel ALK5 Inhibitor TP0427736 Reduces TGF-β Induced Growth Inhibition in Human Outer Root Sheath Cells and Elongates Anagen Phase in Mouse Hair Follicles

research Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles

14 citations , January 2017 in “Pharmacological Reports”

TP0427736 may help treat hair loss by blocking a specific protein and promoting hair growth.

research In the Absence of Streptomycin, Minoxidil Potentiates the Mitogenic Effects of Fetal Calf Serum, Insulin-Like Growth Factor 1, and Platelet-Derived Growth Factor on NIH 3T3 Fibroblasts in a K + Channel-Dependent Fashion

32 citations , August 1996 in “Journal of Investigative Dermatology”

research Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

119 citations , November 2014 in “Trends in Cell Biology”

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Analysis of Thymosin β4 and Vascular Endothelial Growth Factor Expression in Normal Human Tissues Using Tissue Microarray

research Analysis of Thymosin β4 and Vascular Endothelial Cell Growth Factor (VEGF) Expression in Normal Human Tissues Using Tissue Microarray

December 2009 in “Saengmyeong gwahag hoeji/Saengmyeong gwahak hoeji”

Thymosin β4 and VEGF are important for blood vessel formation in many organs.

research Integrated multiple machine learning and Mendelian randomization reveal LTF gene as a prognostic biomarker for nonspecific orbital inflammation

August 2025 in “BMC Pharmacology and Toxicology”

The LTF gene may help predict and manage nonspecific orbital inflammation.

research THE EXPRESSION CHARACTERISTICS AND THEIR BIOLOGICAL SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR AND BASIC FIBROBLAST GROWTH FACTOR IN RAT SKINS AT DIFFERENT DEVELOPMENT STAGES

January 2001 in “Chinese Journal of Reparative and Reconstructive Surgery”

EGF aids skin development and healing, while bFGF absence in embryos may allow scar-free healing.

research Expression of transforming growth factor-beta (TGF-beta 1) and insulin-like growth factor II (IGF-II) messenger RNA in the developing subcutaneous tissue (SQ) of the fetal pig.

11 citations , January 1992 in “PubMed”

TGF-beta 1 and IGF-II mRNA have specific patterns in pig subcutaneous tissue, affecting fat and muscle development.

Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

research WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis

56 citations , January 2022 in “Burns & Trauma”

WNT5A contributes to keloid scars by promoting cell changes through specific signaling pathways.

research Boosting hair follicle regeneration

August 2013 in “Nature Reviews Drug Discovery”

A protein called FGF9 helps regenerate hair follicles in mice after skin damage, and increasing FGF9 could potentially help human hair growth.

research Immunohistological Effects of Transforming Growth Factor-ß via Platelet-Rich Plasma On Segmental Bone Defects: An Animal Study

January 2021 in “TURKISH JOURNAL OF VETERINARY AND ANIMAL SCIENCES”

Platelet-rich plasma speeds up bone healing and reduces complications.

research Activin B Promotes Epithelial Wound Healing In Vivo through RhoA-JNK Signaling Pathway

38 citations , September 2011 in “PLOS ONE”

Activin B helps heal skin wounds and grow hair by activating a specific cell signaling pathway.

research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

215 citations , November 2000 in “Journal of Investigative Dermatology”

The system allows precise control of gene expression in mouse skin, useful for studying skin biology.

research mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration

71 citations , January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

research Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.

January 2009 in “Bradford Scholars (University of Bradford)”

BMP signaling helps prevent skin tumors by blocking cancer-promoting pathways.

research Gfp-Expressing Vascularization of Gelfoam® as a Rapid in Vivo Assay of Angiogenesis Stimulators and Inhibitors

15 citations , March 2007 in “BioTechniques”

The assay quickly identifies substances that increase or decrease blood vessel growth.

research Igf1r signalling acts on the anagen‐to‐catagen transition in the hair cycle

20 citations , January 2017 in “Experimental Dermatology”

Igf1r helps regulate hair growth cycles.

research Contribution à l'étude du lien entre Annonaceae et parkinsonisme : identification et quantification d'acétogénines par déréplication; métabolisation de phase I et approche de la distribution de l'annonacine

February 2012

Thymosin β4 helps with healing, inflammation, and organ protection.

research VEGF165 induces differentiation of hair follicle stem cells into endothelial cells and plays a role in in vivo angiogenesis

36 citations , February 2017 in “Journal of Cellular and Molecular Medicine”

VEGF165 helps hair follicle stem cells become blood vessel cells, aiding new blood vessel growth.

research A Signature of Genes Featuring FGF11 Revealed Aberrant Fibroblast Activation and Immune Infiltration Properties in Keloid Tissue

2 citations , August 2022 in “Emergency medicine international”

Keloid skin disorder involves abnormal fibroblast activation and immune response, linked to a group of genes including FGF11.

research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

1 citations , January 2024 in “Pharmaceuticals”

A new carrier improves skin delivery of tofacitinib for treating inflammatory skin diseases.

research Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling

5 citations , May 2024 in “Developmental Cell”

Lower GATA3 levels in mice help hair regrow by changing certain immune cells.

Bacteria Induce Skin Regeneration via IL-1β Signaling

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