research Topiramate vs Divalproex Sodium in the Preventive Treatment of Migraine: A Prospective “Real‐World” Study
Both topiramate and divalproex sodium effectively reduce migraine frequency and are generally well-tolerated.
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Tamsulosin may slightly increase dementia risk compared to other treatments for enlarged prostate.
research The use of minoxidil to attempt to prevent alopecia during chemotherapy for gynecologic malignancies.
2% Minoxidil does not prevent hair loss during chemotherapy.
research Bladder Cancer Survival of Men Receiving 5α-Reductase Inhibitors
Men taking 5-alpha-reductase inhibitors before or after bladder cancer diagnosis had a lower risk of dying from the disease.
research Clinical effects and economical impact of dutasteride and finasteride therapy in Italian men with LUTS
Dutasteride reduces hospitalization and prostate cancer risk compared to finasteride, potentially offsetting its higher cost.
research COVID and Cancer: A Complete 3D Advanced Radiological CT-Based Analysis to Predict the Outcome
Cancer patients, especially with blood cancers, face severe COVID-19 risks due to weakened immunity.
research Exosome-Based Therapies in Dermatology: A Scoping Review
Exosome-based therapies may improve skin conditions but need more research for safety and effectiveness.
research Beyond Minoxidil: Evidence-Based Off-Label Therapies for Male Androgenetic Alopecia
Some off-label treatments may be effective for male pattern baldness.
research The effect of gonadoliberin analog treatment in precocious puberty on polycystic ovarian syndrome prevalence in adulthood
Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.
research The ethics of placebo-controlled trials: Methodological justifications
research The placebo effect and randomized trials: analysis of conventional medicine
The document concludes that it's important to understand the placebo effect when evaluating the effectiveness of treatments in medical trials.
research Case-Only Trees and Random Forests for Exploring Genotype-Specific Treatment Effects in Randomized Clinical Trials with Dichotomous End Points
Case-only trees and random forests improve predictions of treatment effects in clinical trials.
research Empirical evidence of observer bias in randomized clinical trials: updated and expanded analysis of trials with both blinded and non-blinded outcome assessors
Non-blinded assessors tend to overestimate effects in trials by about 29%.
research Combination Therapies and the Theoretical Limits of Evidence-Based Medicine
The current system can't fully test all combination treatments, so alternative methods and regulatory flexibility are needed.
research Blinding in Placebo-Controlled Trials
The conclusion is that maintaining blinding in clinical trials is crucial for reliable results.
research Fronteggiare l’inaffidabilità della letteratura da studi clinici
Public health decisions should rely on independent trials, not biased literature.
research Select the most correct answers – multiple answers possible for questions 1–11
Medical practitioners need to understand basic statistics to properly evaluate clinical trials and avoid unethical designs.
research Discussion of “A hybrid phase I‐II/III clinical trial design allowing dose re‐optimization in phase III” by Andrew G. Chapple and Peter F. Thall
The new clinical trial design is promising but needs real-world trials to test its effectiveness and possible enhancements.
research Is It Time to Re-Imagine Clinical Trials in Nephrology?
Metatrials could improve clinical research in nephrology by speeding up data collection and overcoming challenges like patient recruitment.
research Aproximación a los metanálisis de comparación de múltiples tratamientos: una revisión de la literatura
Multiple treatment comparison meta-analyses help doctors make better decisions by comparing different interventions.
research The BJUI 's clinical trials initiative
The BJUI supports clinical trials as key for unbiased medical evidence and works to enhance their design, reporting, and discussion.
research Strategy for Generating Blinded Evidence for Single-Arm Trials with External Controls Using Expert Review of Home Video
A new method uses expert reviews of home videos to objectively assess children's developmental milestones in single-arm trials.
research A Randomized Placebo-Controlled Multicentre Study to Evaluate the Safety and Efficacy of Finasteride for Male Chronic Pelvic Pain Syndrome (Category IIIA Chronic Nonbacterial Prostatitis)
research Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata
Ritlecitinib is being tested for effectiveness and safety in treating severe alopecia areata.
research Methodological Quality of Drug Safety Systematic Reviews: A Cross-Sectional Study
Cochrane systematic reviews have better methodological quality than non-Cochrane ones, and improvements are needed for the latter.
research Blinding in Placebo-Controlled Trials
The conclusion suggests that the zinc lozenge study is valid despite imperfect blinding, as many participants could not correctly identify their lozenge type.
research A randomized evaluator blinded study of effect of microneedling in androgenetic alopecia: A pilot study
research PCPT Results Could Affect Trial on Testosterone Replacement
The trial on testosterone replacement therapy in older men faced concerns due to prostate cancer risk.
research Étude PCPT : les biais attendus et leur gestion
Systematic end-of-trial biopsies are the most reliable way to assess outcomes.