research Editorial Comment
More men are using medication for benign prostatic hyperplasia, influenced by marketing and FDA approvals.
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690-720 / 1000+ resultsresearch Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells
Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.
research Pharmacological therapy of benign prostatic hyperplasia/lower urinary tract symptoms: an overview for the practising clinician
Medications have become the main treatment for enlarged prostate symptoms, replacing surgery and watchful waiting.
research Early post-natal neuroactive steroid manipulation modulates ondansetron effects on initial periods of alcohol consumption in rats
Early changes in brain chemicals affect how a drug reduces alcohol intake in rats.
research Silencing the androgen receptor: New skills for antiandrogen oligonucleotide skin and hair therapy
Targeting androgen receptors with antiandrogen oligonucleotides could effectively treat hair loss.
research Testicular Steroidogenesis
Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.
research [Clinical significance of testosterone and dihydrotestosterone metabolism in women].
Antiandrogens and finasteride may help treat excess hair and hair loss in women.
research Androgen Therapy for Postmenopausal Women; What is New?
research Comparison of clinical trials with finasteride and dutasteride.
Dutasteride reduces DHT more than finasteride, but both drugs improve BPH symptoms similarly.
research FDA declines approval of testosterone drug for third time
The FDA did not approve a testosterone drug because of safety concerns.
research Dutasteride: A Review of its Use in the Management of Prostate Disorders
Dutasteride is effective for treating prostate enlargement and reducing related surgery risk, but is not approved for preventing prostate cancer.
research Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
Genetic variations affect dutasteride treatment response for male pattern hair loss.
research Sexual side effects of 5-α-reductase inhibitors finasteride and dutasteride: A comprehensive review
Finasteride and dutasteride can cause sexual problems like impotence and low libido.
research Bicalutamide
research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression
5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.
research Is there a role for 5α‐reductase inhibitors in transgender individuals?
5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.
research Targeting neurosteroid synthesis as a therapy for schizophrenia-related alterations induced by early psychosocial stress
A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.
research Antiandrogen Therapy for Skin and Hair Disease
Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production
Testosterone's muscle-building effects do not require its conversion to DHT.
research Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite
Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
research 5alpha-reductase inhibitors dampen L-DOPA-induced dyskinesia via normalization of dopamine D1-receptor signaling pathway and D1-D3 receptor interaction
Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.
research Anti-Androgenicity of Flutamide and its Metabolite Sch 16423
Flutamide and its metabolite can effectively reduce androgen effects.
research Novel Lead Generation through Hypothetical Pharmacophore Three-Dimensional Database Searching: Discovery of Isoflavonoids as Nonsteroidal Inhibitors of Rat 5α-Reductase
Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.
research Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood
Early-life neurosteroid changes affect adolescent exploration and adult behavior.
research A method for simultaneous analysis of androgens, dutasteride and finasteride in human serum by liquid chromatography tandem mass spectrometry
A new method was developed to analyze certain hormones and drugs in human blood efficiently.
research Synthesis of 11α-hydroxyprogesterone hartens
Researchers successfully made new compounds for hormone level tests, but one attempt led to an unexpected product, correcting a past error.
research Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone
In late pregnancy, allopregnanolone reduces stress responses in rats by affecting brain chemicals.
research 피나스테라이드의 특성에 대한 이론적 연구
Finasteride reduces certain hormone levels to treat prostate issues.
research Molecular Docking and Molecular Dynamics Analysis of Phytochemical Compounds from Nutmeg Fruit (Myristica fragrans Houtt.) on Androgen Receptor (4K7A) as Anti-Alopecia Therapy
Geranylgeraniol from nutmeg may effectively treat hair loss, similar to finasteride and better than minoxidil.
research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals
5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.