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GlossaryNuclear Protein

protein located in cell nucleus involved in DNA processes

A nuclear protein is a type of protein that is located within the nucleus of a cell. These proteins play crucial roles in various cellular processes, such as DNA replication, repair, and transcription, which is the process of copying DNA into RNA. For example, histones are nuclear proteins that help package DNA into a compact, organized structure called chromatin.

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research Results of Complete Blood Cell Count, Fasting Blood Sugar, Rheumatoid Factor, C - Reactive Protein, Anti Nuclear Antibody and Thyroid Function Tests in Patients with Alopecia Areata

April 2011 in “Medical Journal of Tabriz University of Medical Sciences and Health Services”

Many patients with Alopecia Areata have underlying autoimmune disorders, especially thyroid issues.

research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

The hairless protein is important for skin, hair, and may influence cancer development.

research CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations

6 citations , August 2016 in “Journal of Visualized Experiments”

The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research Hairless protein of Jumonji family and hair loss

January 2009

Mutations in the hairless protein gene cause hair loss.

research Genetic Ablation of the CDP/Cux Protein C Terminus Results in Hair Cycle Defects and Reduced Male Fertility

97 citations , March 2002 in “Molecular and cellular biology”

Mutant CDP/Cux protein causes hair defects and reduced male fertility in mice.

research The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression

17 citations , November 2000 in “Journal of Investigative Dermatology”

ZPK helps skin cells mature and may affect skin health.

research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane

60 citations , December 1988 in “Journal of Biochemical Toxicology”

TCDD reduces EGF receptors in the liver, affecting growth and development.

research Filtration of Transgenic Sheep Skin Fibroblasts with KAP6.1-GFP-polymerized Spider Dragline Silk Protein Gene(4S)

January 2011 in “Zhongguo nongye Kexue”

Transgenic sheep cells with spider silk gene were successfully created for future sheep hair expression.

research Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth.

34 citations , September 1997 in “Acta Dermato Venereologica”

RXR agonists may promote hair growth in humans.

Ishige Sinicola Extract Stimulates Osteoblast Proliferation and Differentiation via the Bone Morphogenetic Protein 2/Runt-Related Gene 2 Signaling Pathway

research Ishige sinicola extract stimulates osteoblast proliferation and differentiation via the bone morphogenetic protein 2/runt-related gene 2 signalling pathway

4 citations , May 2019 in “Zeitschrift für Naturforschung C”

Ishige sinicola extract helps bone-building cells grow and mature, which could aid in treating osteoporosis.

research Production of artificial synthetic spidroin gene 4S-transgenic cloned sheep embryos using somatic cell nuclear transfer

16 citations , March 2020 in “Animal Biotechnology”

Transgenic sheep embryos with a specific promoter were successfully created, but more research is needed for gene expression in hair follicles.

research Intermediate filaments: regulation of gene expression and assembly

50 citations , June 1993 in “European journal of biochemistry”

Intermediate filaments are crucial for cell structure and function, regulated by specific genes and proteins.

research The role of activins and follistatins in skin and hair follicle development and function

45 citations , October 2008 in “Cytokine & Growth Factor Reviews”

Activins and follistatins, part of the TGFβ family, are crucial for hair follicle development and skin health, affecting growth, repair, and the hair cycle.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations , September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

research Le gènehairlessde la souris

4 citations , May 2006 in “médecine/sciences”

The hairless gene is crucial for hair health, and its mutations cause hair loss.

CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization

research O19 CYLD cutaneous syndrome tumours demonstrate increased NF-κB signalling and diminished collagen organisation.

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.

research 성장기 모낭에서 큐티클층의 각질화 과정

January 2017 in “대한미용학회지”

The cuticle layer in hair follicles thickens during keratinization due to incomplete cytosol loss.

research MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells

December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.

research Cellular Senescence and Aging in Myotonic Dystrophy

4 citations , February 2022 in “International Journal of Molecular Sciences”

Myotonic Dystrophy may age cells faster, and drugs that target aging could be potential treatments.

research Intracellular protons accelerate aging and switch on aging hallmarks in mice

4 citations , August 2018 in “Journal of cellular biochemistry”

Acid inside cells speeds up aging and turns on aging signs in mice.

research Dynamic Signals for Hair Follicle Development and Regeneration

60 citations , July 2011 in “Stem Cells and Development”

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

research 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes

56 citations , March 2003 in “Journal of Investigative Dermatology”

17β-estradiol can reduce inflammation in the skin.

research Molecular elements of the regulatory control of keratin filament modulator AHF/trichohyalin in the hair follicle

7 citations , July 2008 in “Experimental Dermatology”

The study concluded that a protein important for hair strength is regulated by certain molecular processes and is affected by growth phases.

research
A Case of Rhupus with Rowell Syndrome

3 citations , June 2020 in “Open access rheumatology”

A patient with Rhupus was diagnosed with Rowell syndrome and treated with various medications.

Adipose Tissue Protects Against Skin Photodamage Through CD151- And AdipoQ- EVs

research Stable transfection and identification of a hair follicle-specific expression vector of IGFBP-5 in goat fetal fibroblasts

6 citations , January 2014 in “Genetics and Molecular Research”

The method successfully created stable transfection donor cells for goat hair follicle research.

Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

research Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.