31 citations
,
November 2014 in “Journal of Endocrinological Investigation” Women with androgen excess, especially those with PCOS, have a much higher risk of heart disease and stroke.
October 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Rodent models of PCOS show some similar and some different lipid changes compared to humans.
18 citations
,
January 1990 in “Journal of The American Academy of Dermatology” Lower doses of dexamethasone can safely reduce high DHEAS levels in women with androgenic disorders.
354 citations
,
August 1991 in “Molecular Endocrinology” Human adrenals and gonads have a unique enzyme for steroid hormone production.
October 2025 in “Journal of the Endocrine Society” Leydig cell tumors in the ovary can cause high testosterone and male traits in postmenopausal women but are treatable with surgery.
September 2022 in “Journal of The American Academy of Dermatology” Older women taking spironolactone for hair loss may need yearly potassium checks due to a higher risk of hyperkalemia.
1 citations
,
January 2000 in “PubMed” The treatment slightly increased hair growth and was safe for most women.
September 2022 in “Curēus” The removed ovarian tumor was a rare type of blood vessel tumor that improved the patient's symptoms and hormone levels after surgery.
July 2025 in “AACE Endocrinology and Diabetes” Ovarian hyperthecosis caused high testosterone and virilization symptoms in a 60-year-old woman, which improved after surgery.
74 citations
,
December 1995 in “The Journal of Clinical Endocrinology & Metabolism” Leuprolide plus estrogen is more effective than oral contraceptives for reducing hirsutism.
10 citations
,
February 1976 in “The Journal of Dermatology” γ‐Oryzanol ointment increases sebaceous gland activity and sebum production.
2 citations
,
May 2012 in “Annals of Oncology” Patients with advanced breast cancer and high hormone receptor levels who had surgery for ovarian/pelvic metastases lived longer, especially if they had high estrogen receptor levels.
October 2022 in “Journal of the ASEAN Federation of Endocrine Societies” GnRH-a or orchiectomy is more effective than anti-androgens for managing hormone levels in transgender women.
Women with androgenetic alopecia have normal levels of most blood steroids and binding proteins, but higher dehydroepiandrosterone. Some also have low "sex hormone-binding globulin" and "corticosteroide-binding globulin" capacity, and high "free androgen index" and "free cortisol index". Diane treatment can normalize these levels and improve hair conditions.
37 citations
,
September 2003 in “Journal of Medicinal Chemistry” A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.
May 2024 in “Journal of drug delivery and therapeutics” Women with PCOS have higher oxidative stress and hormone imbalances, suggesting managing oxidative stress could help.
1 citations
,
November 2009 in “Gynäkologische Endokrinologie”
1 citations
,
September 2020 in “Endocrinology, Diabetes & Metabolism Case Reports” The conclusion is that thorough investigation of hypertension and hormonal dysfunctions is important, and there may be a link between these conditions and cancer.
22 citations
,
February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia” An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.
October 2024 in “Journal of the Endocrine Society” Early detection of ovarian steroid cell tumors is crucial to prevent lasting symptoms.
October 2015 in “Reactions Weekly” A woman got a scalp condition from using latanoprost, but it improved after stopping the drug and starting other treatments.
80 citations
,
January 1988 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Spironolactone can cause side effects like irregular bleeding, but lower doses may reduce these effects and still improve hirsutism.
February 2020 in “Diabetologie Und Stoffwechsel” The document concludes that more research is needed to include new treatments in guidelines for Polycystic Ovary Syndrome (PCOS).
18 citations
,
March 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Estrogen increases blood vessel growth factor production, while testosterone blocks this increase.
November 2022 in “Journal of the Endocrine Society” A woman's masculine symptoms were caused by a rare tumor in her left ovary, which was found using a special blood test.
21 citations
,
February 2021 in “BMJ case reports” Anabolic steroid users may face higher risk of severe COVID-19.
3 citations
,
April 2012 in “Osteoporosis International” A woman experienced hair loss after taking strontium ranelate for osteoporosis.
6 citations
,
February 2009 in “Veterinární Medicína” Deslorelin effectively treats hair loss in neutered ferrets by reducing hormone levels.
June 2008 in “Experimental Dermatology” 17-beta estradiol and prednisolone may help regrow hair damaged by chemotherapy.
November 2022 in “Journal of the Endocrine Society” Removing the ovarian tumor improved the woman's hormonal symptoms.