Search

for
Search:

Sort by

Research

870-900 / 1000+ results

research Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib

December 2023 in “Journal of clinical medicine”

Some leukemia treatments can cause skin reactions similar to keratosis pilaris.

research Loss of TET2 Tips the Scales Toward Tumorigenesis

May 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Loss of TET2 increases the risk of skin and oral cancer.

research Author response: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

February 2017

Deleting the MAD2L1 gene is tolerated in certain mouse cancer models.

research Decision letter: Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

October 2016

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

research JAK inhibitors in dermatology: The promise of a new drug class

355 citations , January 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

research ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

224 citations , February 2013 in “The Journal of clinical investigation/The journal of clinical investigation”

ERG increases SOX9, promoting prostate cancer growth and invasion.

research BAC-mediated gene-dosage analysis reveals a role for Zipro1 (Ru49/Zfp38) in progenitor cell proliferation in cerebellum and skin

117 citations , August 1999 in “Nature Genetics”

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

64 citations , March 2004 in “Journal of Clinical Investigation”

Targeting ornithine decarboxylase can help prevent skin cancer.

research Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance

56 citations , January 2023 in “Genes & Diseases”

Repurposing existing drugs and using micronutrients may effectively target cancer stem cells and improve cancer treatment.

research The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model

50 citations , April 2010 in “Biology direct”

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

research Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

47 citations , September 2012 in “Human molecular genetics online/Human molecular genetics”

Folliculin deficiency causes problems with cell division and positioning due to disrupted RhoA signaling and interaction with p0071.

research Existence of Neural Crest–Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium

44 citations , September 2016 in “American Journal Of Pathology”

Neural crest-derived progenitor cells in the cornea could help treat corneal issues without transplants.

research Polycystic ovary syndrome and its management: In view of oxidative stress

35 citations , January 2024 in “BioMolecular Concepts”

Lifestyle changes, exercise, and antioxidants can help manage polycystic ovary syndrome.

research Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

10 citations , August 2013 in “Experimental Dermatology”

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

research Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

5 citations , June 2024 in “Pharmacological Research”

FOL-026 peptide may help hair growth and cardiovascular health by improving blood flow and cell functions.

research The color of skin: white diseases of the skin, nails, and mucosa

4 citations , July 2019 in “Clinics in Dermatology”

The document concludes that while white skin, nail, and mucosa diseases increase skin cancer risk, they are generally harmless, especially compared to darker pigmentation conditions.

research Building Models for Keratin Disorders

4 citations , April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Krt16-deficient mice help understand skin disorders like PC and FNEPPK.

research A Study of Combined Genotype Effects of SHCBP1 on Wool Quality Traits in Chinese Merino

3 citations , August 2022 in “Biochemical Genetics”

research Epidermolysis Bullosa Simplex Keratinocytes Show Disturbed Mitochondrial Positioning and Activity

3 citations , January 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

Skin cells from people with Epidermolysis Bullosa Simplex have abnormally placed and less active mitochondria.

research Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA

3 citations , February 2018 in “Experimental and Molecular Medicine/Experimental and molecular medicine”

A protein called PCBP2 controls the production of a hair growth protein by interacting with its genetic message and is linked to hair loss when this control is disrupted.

research ST14 interacts with TMEFF1 and is a predictor of poor prognosis in ovarian cancer

March 2024 in “BMC cancer”

High levels of ST14 and TMEFF1 proteins in ovarian cancer are linked to worse patient outcomes and may be a new treatment target.

research Calcineurin/Nuclear Factor of Activated T-Cell Pathway in Cutaneous Squamous Cell Carcinoma

August 2019 in “International journal of dermatology and venereology”

The calcineurin/NFAT pathway plays a significant role in the development and growth of a type of skin cancer called cutaneous squamous cell carcinoma.