research Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse
Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
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300-330 / 1000+ results research Optimized skin optical clearing for optical coherence tomography monitoring of encapsulated drug delivery through the hair follicles
A PEG-400/oleic acid mixture best improves drug delivery monitoring through hair follicles.
research Complex Regional Pain Syndrome I (Reflex Sympathetic Dystrophy)
CRPS type I is a complex pain condition with no proven cure, requiring personalized treatment.
research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids
Chronic ethanol increases certain brain receptor levels, influenced by steroids and protein changes.
research Chronic Overlapping Pain Conditions and Nociplastic Pain
Nociplastic type pain, common in Chronic Overlapping Pain Conditions, is a complex, heritable trait linked to 24 unique genetic factors and 127 genes, with potential shared mechanisms in cognitive, personality, and metabolic traits.
research Comparative Evaluation Of Combined Use Of Intravenous Dexmedetomidine-Ketamine With Dexmedetomidine Alone Along With Peripheral Nerve Blocks For Split Skin Grafting From Lower Limbs In Adults
Combining dexmedetomidine and ketamine provides better sedation and pain relief than dexmedetomidine alone.
research Medications Altering Sex Hormone Balance and Risk of Advanced Liver Disease in HCV-infected Males
Methadone may worsen liver fibrosis in males with HCV.
research Enzyme Inhibitors from Gorgonians and Soft Corals
Marine compounds from gorgonians and soft corals show promise for drug development, especially for chronic disorders.
research Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat
Finasteride reduces pain in male rats and works better with testosterone.
research The use of anabolic androgenic steroids: A focus on polypharmacy
Using high doses and multiple drugs with steroids is risky and should be prevented.
research Hydroxylation of dehydroepiandrosterone in human scalp hair folhcles
The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.
research Minimizing pain for liposuction anesthesia.
The document's conclusion cannot be provided because the document is not available or cannot be read.
research Truncal anesthesia for hair mesotherapy
Using truncal anesthesia on the supraorbital nerve reduces pain in hair loss treatments and improves patient comfort.
research POPPER MACULOPATHY: LONG-TERM FOLLOW-UP AND CASE SERIES
Using poppers can cause vision problems, but stopping their use might lead to complete recovery over time.
research Facile One-Pot Synthesis of Substituted Hydantoins from Carbamates
Scientists in India found a safer and efficient way to make a type of medicine called hydantoins from carbamates, which also worked well in making the seizure medicine, Ethotoin.
research Chemical Profiling, Pharmacological Insights and In Silico Studies of Methanol Seed Extract of Sterculia foetida
Sterculia foetida seed extract shows promise for therapeutic use due to its anti-inflammatory and pain-relief properties.
research Ovarian Cycle‐Related Neurosteroid Regulation of GABA‐A Receptor Subunit Plasticity in the Hippocampus Subfields
Progesterone-derived neurosteroids affect GABA-A receptor expression, influencing epilepsy during menstrual cycles.
research Oriental herbal medicine and moxibustion for polycystic ovary syndrome
Oriental herbal medicine with moxibustion may improve pregnancy rates and other symptoms in PCOS, but more high-quality research is needed.
research Mechanisms responsible for progesterone's protection against lordosis-inhibiting effects of restraint II. Role of progesterone metabolites
Allopregnanolone, a progesterone metabolite, helps reduce restraint effects on behavior.
research A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti‐oestrogen drugs and synthetic anabolic steroids
A quick method effectively detects banned substances in urine.
research Signaling pathways in the mechanisms of drug action
Signaling pathways are key targets for developing effective drugs.
research PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo
The new drug delivery systems made with surfactants and block polymers are stable and not toxic.
research Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen
In 2017, a new method was created to efficiently produce a topical antiandrogen, a compound used to treat excess sebum and acne, with a high yield and purity.
research Mechanistic insights of desmopressin loaded elastic liposomes for transdermal delivery: HSPiP predictive parameters and instrumental based evidences
Desmopressin-loaded liposomes can effectively deliver drugs through the skin, improving bioavailability and patient compliance.
research SUN-439 Hypothalamic-Pituitary-Adrenal Axis Disruption from Unregulated Glucocorticoid Use: A Case Series
Unregulated glucocorticoid use can disrupt hormone balance and cause serious health issues.
research Empathic disequilibrium is related to lower levels of hair oxytocin in humans
research TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model
Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.
research Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism
Blocking CRF-R1 can reduce alcohol intake in stressed mice.
research Enhanced delivery of drugs into and across the skin by ethosomal carriers
Ethosomal carriers improve drug delivery through the skin better than traditional methods.
research OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles.
Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.