research PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function
Euph E and Euri A from Euphorbia neriifolia help control inflammation and immune response in cells.
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research An Overlooked Sequela of Long-Term Opioid Analgesic Use: A Case Report on Central Adrenal Insufficiency
Long-term opioid use can cause a serious condition where the adrenal glands don't work properly, which doctors should watch out for.
research ODP056 The Treatment of Opioid Addiction Leading to Secondary Adrenal Insufficiency
Long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency.
research Long-term opioid ADR management in cancer patients
Many medications can cause hair loss or excessive hair growth, which is usually reversible after stopping the drug.
research The 5α-reductase inhibitor finasteride reduces opioid self-administration
Finasteride may help reduce opioid use.
research The Opiate Antagonist, Naltrexone, in the Treatment of Trichotillomania
Naltrexone did not significantly reduce hair pulling but improved cognitive flexibility.
research A practical approach to feline symmetrical alopecia
The conclusion is to thoroughly test for causes of cat hair loss and treat accordingly, considering medication only after serious conditions are ruled out.
research Alopecia and Associated Toxic Agents: A Systematic Review
Thallium, mercury, selenium, and colchicine strongly cause hair loss.
research Ocfentanil testing in hair from a fatality case: Comparative analysis of a lock of hair versus a single hair fiber
Both a lock of hair and a single hair strand can show chronic drug use, but at least six single hairs are needed for accurate results.
research This Week in JAMA
Early surgery reduces seizure risk in drug-resistant epilepsy; testosterone to DHT conversion doesn't affect muscle anabolism; veterans with PTSD likely to have riskier opioid use; bevacizumab helps in hereditary bleeding disorder.
research 高校体育教育模式创新研究——以“三选”体育教学模式为例
Curcumin shows promise for pain relief but needs more research for effective use.
research Trichotillomania Successfully Treated With Risperidone and Naltrexone: A Geriatric Case Report
Trichotillomania was successfully treated with risperidone and naltrexone.
research Walrus
Anesthetizing walruses is difficult and risky due to their size and sudden health changes.
research Hair
Hair analysis can detect drug use but is costly and interpretation is complex.
research ς1Receptor-Related Neuroactive Steroids Modulate Cocaine-Induced Reward
Neuroactive steroids affect cocaine's rewarding effects through the ς1 receptor.
research Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.
Neuroactive steroids affect cocaine's rewarding effects through the sigma1 receptor.
research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure
Morphine increases testosterone breakdown in the rat brain and spinal cord.
research Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
Formyl-peptide receptor agonists could be new anti-inflammatory drugs.
research Pharmacovigilance-based drug repurposing: searching for putative drugs with hypohidrosis or anhidrosis adverse events for use against hyperhidrosis
Certain existing drugs, like glycopyrronium and botulinum toxin type A, may help treat excessive sweating.
research Relating neurosteroid modulation of inhibitory neurotransmission to behaviour
Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.
research Disease modifying osteoarthritis drug discovery using a temporal phenotypic reporter in 3D aggregates of primary human chondrocytes
Aromoline and DRD4 are potential targets for osteoarthritis treatment.
research Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction
Neurosteroids may help metyrapone reduce cocaine addiction.
research Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors
14,15-EET may help reduce poststroke pain by affecting certain brain proteins.
research Stability of opiates in hair fibers after exposure to cosmetic treatment
Cosmetic treatments like bleaching and perming can greatly reduce opiate levels in hair, possibly leading to false-negative drug tests.
research Neuroactive steroids inhibit spinal reflex potentiation by selectively enhancing specific spinal GABAA receptor subtypes
Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.
research ABSTRACTS—SYMPOSIA
Certain drugs can block changes in brain receptors caused by alcohol withdrawal.
research Medicinal Chemistry of Drugs with N-Oxide Functionalities
N-oxides are important in medicine for improving drug properties and targeting.
research Where it all went right
Some drugs have gained approval for new uses, while others like tricyclic antidepressants and aspirin show promise but aren't yet approved for these uses.
research Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain
PEA reduces pain by increasing neurosteroid synthesis in the spinal cord.
research Neuroactive Steroids: Functions, Mechanisms of Action and Physiologic Relevance
Allopregnanolone may enhance alcohol's effects on dopamine neurons, influencing addiction risk.