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Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

research Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: From potassium channel openers to calcium entry blockers?

6 citations , April 2014 in “European journal of medicinal chemistry”

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

research Stability studies of antiandrogenic compounds in Curcuma aeruginosa Roxb. extract

10 citations , June 2014 in “Journal of Pharmacy and Pharmacology”

Germacrone in Curcuma aeruginosa extract degrades at high temperatures but is stable in certain solutions and unaffected by pH levels.

research Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment

September 2024 in “Journal of Ethnopharmacology”

Terminalia bellirica extracts effectively promote hair regrowth and treat androgenetic alopecia.

research Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen–glucose deprivation

83 citations , November 2006 in “European Journal of Neuroscience”

Progesterone protects rat brain cells by enhancing GABA A receptor activity.

Development of the Emulsion Base Composition for Creating a Medicinal Cosmetic Product Used in Androgenetic Alopecia

research Development of the emulsion base composition when creating the medicinal cosmetic product used in androgenetic alopecia

1 citations , June 2014 in “Vìsnik farmacìï”

A medicinal cosmetic product for treating Androgenetic Alopecia was developed using plant-based substances, Saw palmetto and Japanese Sophora, with pumpkin seed oil and stabilizers like Carbopol, sodium alginate, xanthan gum, Tween-20 and cetyl alcohol.

research The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo

17 citations , January 2023 in “Frontiers in Pharmacology”

2Br-Crebanine and Stephanine reduce inflammation and pain effectively.

research The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase

64 citations , June 1995 in “Steroids”

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Preparation of 4-Aryl-2-Trifluoromethylbenzonitrile Derivatives as Androgen Receptor Antagonists for Topical Suppression of Sebum Production

research Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production

11 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

Scientists made a chemical (compound 4e) that can be applied on skin to reduce oil production, which can help with acne, but it might cause skin sensitivity to light.

research Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil

1 citations , October 2017 in “Food Additives & Contaminants: Part A”

A new minoxidil-like substance, triaminodil, was found in an illegal hair growth supplement.

In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands

research In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands

September 2020 in “Current Enzyme Inhibition”

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

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