research Wnt is back in drugmakers' sights, but is it druggable?
Drugmakers are optimistic about targeting the Wnt pathway for new treatments despite past challenges.
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research Polycystic Ovary Syndrome: Features, Diagnostic Criteria and Treatments
PCOS is a long-term condition that needs more research for better understanding and treatment.
research The effect of minocycline on the metabolism of androgens by human oral periosteal fibroblasts and its inhibition by finasteride
Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.
research Management of acne vulgaris with hormonal therapies in adult female patients
Hormonal therapies, like flutamide and cyproterone acetate, are safe and effective for treating adult women's acne, especially those with hormone imbalance or resistant acne.
research Cardiac flow parameters with conventional and pulsed tissue Doppler echocardiography imaging in patients with polycystic ovary syndrome
Young women with PCOS and no other heart risk factors have normal heart function.
research Hirsuties
Hirsutism in women is often due to hormone sensitivity and has significant psychological effects.
research An unusual presentation of dermatomyositis: The type Wong variant revisited
A woman with a rare type of dermatomyositis improved with low-dose prednisone and methotrexate.
research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole
Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.
research Spironolactone in dermatology: uses in acne and beyond
Spironolactone is a low-cost, effective, and generally safe treatment for various skin conditions related to hormones.
research Infundibular protein and RNA microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients
Finasteride helps female-pattern hair loss.
research Autoimmune gastritis and parietal cell reactivity in two children with abnormal intestinal permeability
Children with autoimmune gastritis showed improved intestinal health over time and should be checked for other autoimmune conditions.
research Treatment of hyperandrogenism in women
Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.
research Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study
Women with PCOS are at high risk of glucose metabolism issues and heart diseases, especially if overweight, highlighting the need for early intervention.
research EVALUATION OF ASSOCIATION OF ANTHROPOMETRIC INDICES WITH STRESS RESPONSE IN PCOS POPULATION
Stress worsens symptoms and body changes in women with PCOS, especially during COVID-19.
research Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome
The document concludes that HAIR-AN syndrome should be considered when a patient shows severe hyperandrogenism and insulin resistance after excluding tumors.
research Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + – a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment
Newly found stem cells in horse hooves show promise for treating a hoof disease called laminitis.
research Human skin
Estrogen deficiency, like after menopause or certain surgeries, leads to faster skin aging and health issues.
research Skin Diseases in Horses
Horse skin diseases are complex to manage and often require a biopsy for accurate diagnosis and treatment.
research Testosterone concentrations and oligomenorrhea in women with acne
Women with acne and irregular periods had higher active testosterone levels, which could suggest the usefulness of antiandrogen treatment.
research Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling
Sonic hedgehog signaling helps heal pressure ulcers by improving blood vessel growth.
research How to Evaluate Acne in Reproductive-Age Women: An Epidemiological Study in Chinese Communities
Acne in reproductive-age women may be linked to conditions like PCOS and lifestyle factors, so doctors should check for these when treating acne.
research Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway
Cepharanthine can potentially treat gastric cancer by stopping tumor growth.
research A role for steroid 5 alpha-reductase 1 in vascular remodeling during endometrial decidualization
The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
research The Effects of Ficus carica on Male and Female Reproductive Capabilities in Rats
Ficus carica extract improved fertility in rats and may help with certain health conditions.
research Impact of Testosterone on Hair and Skin
Testosterone can cause acne and male-pattern baldness, affects hair growth in men and women, and makes male skin more sensitive.
research Diseases of the Hair and Nails
Stress, nutritional issues, and chronic diseases can cause hair loss, and nail changes may signal internal diseases; treatment focuses on the underlying cause.
research Can the Second to Fourth Digit Ratio (2D : 4D) Be a Marker to Determine Ankylosing Spondylitis Disease Activity?
The index to ring finger ratio may indicate disease severity in female ankylosing spondylitis patients, but not in males.
research Non-clinical safety evaluation and risk assessment to human of aleglitazar, a dual PPAR α/γ agonist, and its major human metabolite
Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.
research Nonalcoholic fatty liver disease in young adult Egyptian women with polycystic ovary syndrome
Many young Egyptian women with PCOS also have fatty liver disease, especially if they are overweight and insulin resistant.
research Hair loss in hospital medicine: a practical guide
The guide helps clinicians diagnose and manage hair loss, detailing examination techniques and treatments for different types of alopecia.