research A phase I study of MK-5108, an oral aurora A kinase inhibitor, in both monotherapy and in combination with docetaxel in patients with advanced solid tumors.
MK-5108 is safe and shows potential against tumors, especially alone.
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630-660 / 1000+ resultsresearch IP28-24 RISK OF ERECTILE DYSFUNCTION AMONG REPRODUCTIVE-AGED MEN FOLLOWING LOW-DOSE FINASTERIDE USE FOR ANDROGENETIC ALOPECIA: A PROPENSITY-MATCHED COHORT STUDY
Low-dose finasteride may increase erectile dysfunction risk over time.
research Fatal Toxic Epidermal Necrolysis Associated with Minoxidil
Minoxidil can cause deadly skin reaction; monitor patients closely.
research Pharmacophore Models for Toxicology Prediction
Pharmacophore models can predict liver toxicity and central nervous system toxicity, but they have limitations and specific requirements.
research Hyperammonemic encephalopathy without hepatic dysfunction due to treatment with valproate: four cases and a mini review
Valproate can cause brain swelling with high ammonia levels, possibly underreported, especially in psychiatric patients.
research Blue-gray discoloration of the skin after levofloxacin exposure in a 44-year-old man with pulmonary tuberculosis
Levofloxacin may cause skin discoloration and hair loss as side effects.
research Finasteride 1 mg has no inhibitory effect on omeprazole metabolism in extensive and poor metabolizers for CYP2C19 in Japanese
Finasteride doesn't affect omeprazole metabolism in Japanese people.
research OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles.
Machine learning identified three unique subtypes of androgen excess in women with PCOS, each with different metabolic risks.
research The measurement of a new antimicrobial quinolone in hair as an index of drug exposure.
Measuring OPC-17116 in hair can reliably indicate drug exposure and timing.
research Real-world pharmacovigilance insights into drug-induced risk of alopecia
64 drugs can cause hair loss, needing better monitoring and updated labels.
research Wording Creates Misunderstanding
A drug helped quickly reduce a movement disorder, experts debated the severity of Raynaud phenomenon, and rapid weight loss was linked to temporary hair loss with good recovery.
research Pharma maker recalls drug over undeclared anti-hypertensive drug
A medicine company has recalled a drug because it contained an unlisted blood pressure medication.
research СУДОВО-МЕДИЧНА ХАРАКТЕРИСТИКА ГОСТРИХ ОТРУЄНЬ СПОЛУКАМИ ТАЛІЮ ТА ЇХ ВІДДАЛЕНИХ НАСЛІДКІВ
Thallium poisoning is highly toxic and can cause severe health issues or death.
research Urinary Incontinence due to Overactive Detrusor Muscle: A Rare Side Effect of Venlafaxine
Venlafaxine can cause urinary incontinence in rare cases.
research Additional Benefit Scoring During Health Technology Assessment in Germany - Its Drivers and Impact on Pricing and Discount for Orphan Drugs
Orphan drug benefit scores in Germany are influenced by phase III data and lack of alternatives, but not linked to price or discounts.
research Phase I safety and pharmacokinetic study of SU-014813 in combination with docetaxel in patients with advanced solid tumours
The drug combination was safe and showed promise in treating advanced tumors.
research The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice
Neurosteroids in the brain can increase or decrease seizure risk in mice.
research Skin Toxicity in Palliative Radiation Therapy
Radiation therapy for cancer often causes skin problems like redness, dryness, and pain.
research Omeprazole-induced hypertrichosis in two children
Two children grew extra hair from taking omeprazole, which went away after they stopped the medication.
research 452: HAIR-RAISING TOXICITY: STATUS EPILEPTICUS FOLLOWING HAIR RESTORATION DUE TO LAST AND TXA TOXICITY
Hair restoration can cause severe seizures due to combined drug toxicity.
research Mitoxantrone
Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.
research Topical imiquimod—Be aware of the unexpected
A woman had a severe skin reaction from the drug imiquimod, used for skin cancer, highlighting the need for awareness of rare but serious side effects.
research Weekly docetaxel in minimally pretreated cancer patients: A dose-escalation study focused on feasibility and cumulative toxicity of long-term administration
Giving docetaxel weekly at 40 mg/m² is manageable and has low toxicity for cancer patients.
research Acute severe hypokalemia caused by treatment of tongue squamous cell carcinoma with docetaxel and cisplatin: A case report
Chemotherapy with docetaxel and cisplatin can cause severe low potassium, requiring careful monitoring and treatment.
research Medical complications of anorexia nervosa and bulimia nervosa
Anorexia and bulimia lead to serious health problems and increased risk of death, requiring aggressive treatment.
research Miscellaneous Exogenous Hormones and Breast Diseases: A Matter of Concern for the Gynecologist
Some hormone treatments might raise breast cancer risk, while others don't seem to.
research Impact of a health alert and its implementation on flutamide prescriptions for women: an interrupted time series analysis
Health warnings and public health actions led to a significant drop in flutamide prescriptions for women, but off-label use still continues.
research Side-effects and possible complications of oral contraceptive drugs.
Oral contraceptives can cause nausea, headaches, mood changes, and other side effects, especially early on.
research Risk of estrogen-driven malignancies in females on 5-alpha reductase inhibitors
research Pericardial Disorders Occurring during Open Label Study of 3747 Patients Treated with Systemic Minoxidil
Low-dose oral minoxidil is safe for the heart.