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Discovery of 7-Methoxy-6-[4-(4-Methyl-1,3-Thiazol-2-yl)-1H-Imidazol-5-yl]-1,3-Benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

research Discovery of 7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole (TASP0382088): A Potent and Selective Transforming Growth Factor-β Type I Receptor Inhibitor as a Topical Drug for Alopecia

6 citations , January 2013 in “Chemical & pharmaceutical bulletin/Chemical and pharmaceutical bulletin”

A new compound shows promise as a topical treatment for hair loss.

Synthesis and Pharmacological Properties of Heterocyclic Steroids

research Miscellaneous Steroids

October 2010

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

Synthesis and Structure–Activity Investigation of Iodinated Arylhydantoins and Arylthiohydantoins for Development as Androgen Receptor Radioligands

research Synthesis and structure–activity investigation of iodinated arylhydantoins and arylthiohydantoins for development as androgen receptor radioligands

6 citations , November 2004 in “Bioorganic & Medicinal Chemistry Letters”

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Benzothiazepines, Diltiazem, and JTV-519 Exert Anxiolytic-Like Effects via Neurosteroid Biosynthesis in Mice

research Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice

1 citations , March 2020 in “Journal of Pharmacological Sciences”

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

Development of a Spectrophotometric Method to Determine Minoxidil by Diazotization-Coupling Reaction with Sulfanilic Acid

research Development of a Spectrophotometric Method to determination Minoxidil by Diazotization-Coupling reaction with Sulfanilic acid

June 2025 in “Samarra Journal of Pure and Applied Science”

A new method accurately measures minoxidil in tablets.

research Breaking the ‘rule-of-five’ to access bridged bicyclic heteroaromatic bioisosteres

February 2026 in “Nature Synthesis”

A new method creates unique chemical structures that could improve drug discovery.

research Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights

December 2025 in “Biomolecules”

Compound 7p shows strong potential as an anticancer agent.

research Nitroxide pharmaceutical development for age-related degeneration and disease

24 citations , November 2015 in “Frontiers in Genetics”

Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

research Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

133 citations , November 2018 in “Aging”

Azithromycin and Roxithromycin can remove aging cells and may help with anti-aging.

research Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5α-Reductase Inhibitors

3 citations , August 2010 in “Letters in Drug Design & Discovery”

research Crystal Structure of Minoxidil

5 citations , January 2004 in “Analytical Sciences X-ray Structure Analysis Online”

Minoxidil's crystal structure shows two different molecule shapes and nitrogen states.

In Silico Investigation of Possible Multi-Target Drugs Against Glutamate S-Transferase and Prolyl tRNA Synthetase in Onchocerca Volvulus

research In silico investigation of possible multi-target drugs against Glutamate S-transferase and prolyl tRNA synthetase in Onchocerca volvulus

June 2026 in “Open Access Research Journal of Biology and Pharmacy”

Bedaquiline, Telmisartan, Diosmin, Azelastine, and Adapalene may be effective treatments for onchocerciasis.

research Aromatic C-nitrosation of a bioactive molecule. Nitrosation of minoxidil

8 citations , January 2011 in “Organic and Biomolecular Chemistry”

Minoxidil reacts to nitrosation 7 times more than phenol, mainly due to its -NH₂ groups, leading to the creation of N-nitrosominoxidil.

research Docetaxel and oxaliplatin in the second-line treatment of platinum-sensitive recurrent ovarian cancer: a phase II study

29 citations , August 2007 in “Annals of Oncology”

Docetaxel and oxaliplatin are effective and have manageable side effects for recurrent platinum-sensitive ovarian cancer.

research Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

23 citations , February 2010 in “European Journal of Medicinal Chemistry”

research Kinetic analysis of LY320236: competitive inhibitor of type I and non-competitive inhibitor of type II human steroid 5α-reductase

11 citations , January 2000 in “The Journal of Steroid Biochemistry and Molecular Biology”

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

research Alfuzosin/finasteride

May 2023 in “Reactions Weekly”

research Alfuzosin/finasteride

January 2013 in “Reactions Weekly”

research The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

1 citations , January 2022 in “Journal of Cancer Therapy”

Ocoxin improves quality of life for advanced ovarian cancer patients on chemotherapy.

A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

research A Thallium-Based Screening Procedure to Identify Molecules That Modulate the Activity of Ca2+-Activated Monovalent Cation-Selective Channels

5 citations , January 2018

The conclusion is that a new test was created to find substances that affect specific ion channels, and it works well for drug discovery.

research Minoxidil

June 2015 in “Reactions weekly”

research Minoxidil

December 2012 in “Reactions weekly”

Crystal Structure and Synthesis of 3β-Benzoyloxy-4-pregnen-16α,17α-epoxy-6,20-dione

research Crystal Structure and Synthesis of 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione

January 2004 in “Analytical Sciences: X-ray Structure Analysis Online”

The document explains how to make a compound called 3.BETA.-Benzoyloxy-4-pregnen-16.ALPHA.,17.ALPHA.-epoxy-6,20-dione and describes its crystal structure.