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research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

HPV8 E6 Induced STAT3 Activation Leads to Hair Follicle Junctional Zone Keratinocyte Stem Cell Proliferation and Expansion in Actinic Keratoses

research 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

HPV8 causes hair follicle stem cells to grow, leading to skin lesions.

research Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis

7 citations , August 2022 in “Nature communications”

A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.

research Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis

5 citations , September 2010 in “Cancer Prevention Research”

The research suggests new treatments for skin cancer could target specific cell growth pathways.

research A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse

44 citations , March 2012 in “Molecular Carcinogenesis”

Keratin 15 cells from hair follicles help develop and maintain skin tumors in mice.

research Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma

10 citations , December 2015 in “International Journal of Dermatology”

CK 15, follistatin, and Bmi-1 can help differentiate basal cell carcinoma from squamous cell carcinoma.

Characterization of CD4+ Stem Cells of the Skin and Their Role in Skin Homeostasis and Tumorigenesis

research Characterisation of CD4+ stem cells of the skin and their role in skin homeostasis and tumourigenesis

1 citations , January 2021

CD4+ skin cells may be precursors to basal cell carcinoma.

research Citrulline-containing basal cell carcinomas. Differentiation toward hair structures with induction of dermal hair papillae

21 citations , September 1968 in “Cancer”

Citrulline in certain skin tumors suggests they mimic hair growth, helping distinguish them from other cancer types.

research Distinct expression profile of stem cell markers, LGR5 and LGR6, in basaloid skin tumors

9 citations , January 2017 in “Virchows Archiv”

LGR5 and LGR6 are expressed differently in various skin tumors, which may offer clues about their origins.

research Abstract 5020: Characterization of epidermal stem cells in SKH1 hairless mice, a widely used mouse model to investigate ultraviolet radiation carcinogenesis.

April 2013 in “Cancer Research”

SKH1 hairless mice have identifiable epidermal stem cells with specific markers.

research Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.

104 citations , July 1994 in “The Journal of Cell Biology”

Basonuclin helps keratinocytes multiply and prevents them from fully maturing.

Analysis on the Maintenance Mechanisms of Human Interfollicular Epidermal Stem Cells and Their Niche

research Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche

September 2016 in “Journal of dermatological science”

Epidermal stem cells use integrin β1 and α6 as markers and CD271+ cells help maintain skin health and heal wounds.

research Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes

27 citations , February 2003 in “European Journal Of Oral Sciences”

SVpgC2a cells show abnormal growth and keratin changes, modeling early cancer development.

research Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment

14 citations , January 2021 in “Stem cell research & therapy”

Human skin cells with stem-like features can help create new hair follicles and sebaceous glands when combined with other cells.

research Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7

1 citations , November 2023 in “Journal of Microbiology and Biotechnology”

Immortalized human dermal papilla cells were created that grow better and can still help form hair.

research Defining and targeting differentiation of non-melanoma skin cancer

June 2014

Basal cell carcinoma behaves like hair follicles and targeting specific pathways may help treat it.

research Transient expression of keratin 19 is induced in originally negative interfollicular epidermal cells by adhesion of suspended cells.

25 citations , October 2005 in “PubMed”

Keratin 19 expression in certain skin cells is temporary and not a reliable stem cell marker.

research Basal Lamina Changes During Tissue Interactions in Hair Follicles—An In Vitro Study of Normal Dermal Papillae and Vitamin A-Induced Glandular Morphogenesis

34 citations , January 1983 in “Journal of Investigative Dermatology”

research Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell?

153 citations , October 2007 in “Cell Stem Cell”

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

research Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro

135 citations , November 1987 in “Differentiation”

Outer root sheath cells consistently express certain keratins influenced by their environment.

research Differential diagnosis of basal cell carcinoma and benign tumors of cutaneous appendages originating from hair follicles by using CD34.

13 citations , January 2010 in “PubMed”

research Cellular and Immunological Aspects of Basel Cell Carcinoma

October 1998 in “Data Archiving and Networked Services (DANS)”

Basal cell carcinoma cases are rising globally.

research The Insulin-like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

128 citations , March 1996 in “Journal of Investigative Dermatology”

research Abstract 5202: Bone marrow-derived epithelial cells contribute to chronic skin inflammation and skin tumor formation in the mouse

April 2012 in “Cancer Research”

Bone marrow-derived cells can lead to skin inflammation and tumors in mice.

research Gate keeping the sebaceous gland

August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research found that specific stem cells maintain skin gland openings and that disrupting their activity can cause blockages or early cancer signs, indicating a need for targeted treatments.

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