Mutations in the PADI3 gene may cause central centrifugal cicatricial alopecia in women of African ancestry.
September 2019 in “Journal of Investigative Dermatology” CCCA in women of African ancestry may be caused by PADI3 gene mutations and intense hair grooming.
150 citations
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October 2010 in “The American Journal of Pathology” The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.
June 2020 in “Journal of Investigative Dermatology” Hair shaft malformation contributes to Central Centrifugal Cicatricial Alopecia.
March 2015 in “Zagazig University Medical Journal” Damage to hair follicle stem cells may cause permanent hair loss and scarring in PCA.
39 citations
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November 2009 in “Clinical and Experimental Dermatology” Immune privilege collapse in hair follicles may cause permanent hair loss in certain conditions.
16 citations
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November 2022 in “American Journal of Clinical Dermatology” 1 citations
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December 2023 in “JAAD International” Mast cells may significantly contribute to central centrifugal cicatricial alopecia.
October 2022 in “Benha Journal of Applied Sciences” People with non-scarring hair loss have higher levels of DKK-1, a protein linked to hair growth, than those with scarring hair loss or no hair loss.
December 2020 in “Journal of Endocrinology and Reproduction” Certain inflammatory molecules and leptin may contribute to hair loss in cicatricial alopecia.
38 citations
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January 2019 in “International Journal of Women's Dermatology” The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.
4 citations
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November 2021 in “Biomedicines” New digital tools are improving the diagnosis and understanding of irreversible hair loss conditions.
1 citations
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July 2018 in “Elsevier eBooks” FAPD and possibly CCCA may be AGA subtypes, and treatments combining antiandrogens, hair growth agents, hair transplants, and anti-inflammatories could be effective.
7 citations
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January 2013 in “Journal of Investigative Dermatology” Vitamin A may influence hair loss conditions like alopecia, but more research is needed to understand how.
37 citations
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January 2019 in “BioMed Research International” Itchy scalp is common, linked to various conditions, and hard to treat effectively.
31 citations
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January 2009 in “Autoimmunity Reviews” Damage to hair follicle stem cells causes permanent hair loss and scarring in cutaneous lupus erythematosus.
35 citations
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July 2008 in “Dermatologic therapy” Cicatricial alopecia may be caused by immune attacks on hair follicles, gland issues, or stem cell damage.
44 citations
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April 2012 in “American Journal of Clinical Dermatology” Scarring alopecias are complex hair loss disorders that require early treatment to prevent permanent hair loss.
44 citations
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November 2011 in “The Journal of Dermatology” New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.
15 citations
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February 2006 in “Journal of Investigative Dermatology” More research is needed to understand and treat cicatricial alopecias.
25 citations
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June 2018 in “Journal of The American Academy of Dermatology” Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.
22 citations
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January 2018 in “Experimental Dermatology” The meeting focused on understanding, diagnosing, and finding treatments for irreversible hair loss diseases.
22 citations
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October 2012 in “Journal of Investigative Dermatology” Altered retinoid metabolism in cicatricial alopecia suggests a balanced vitamin A diet may prevent the condition.
5 citations
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January 2024 in “JID Innovations” CCCA involves immune response and metabolism issues, suggesting new treatment options.
2 citations
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July 2023 in “JAAD Case Reports” A woman with a type of hair loss saw hair regrowth after two months of taking baricitinib.
September 2024 in “Portuguese Journal of Dermatology and Venereology” CCCA and LPP may be related hair loss conditions influenced by genetics and environment, needing early treatment.
June 2024 in “Journal of the European Academy of Dermatology and Venereology” Allergens might contribute to CCCA, so avoiding them could help manage the condition.
September 2022 in “Skin appendage disorders” Seborrheic dermatitis may contribute to the development of central centrifugal cicatricial alopecia.
19 citations
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July 2022 in “PNAS Nexus” Similar treatments might work for different types of scarring hair loss.
16 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” New treatments and early diagnosis methods for permanent hair loss due to scar tissue are important for managing its psychological effects.